5455-13-0

Basic information

• Product Name: 5-bromobiphenyl-2-amine
• Synonyms: [1,1'-biphenyl]-2-amine, 5-bromo-; 5-Bromo-2-biphenylamine
• CAS NO: 5455-13-0
• Molecular Formula: C₁₂H₁₀BrN
• Molecular Weight: 248.1185
• Mol File: 5455-13-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 328.8°C at 760 mmHg
• Flash Point: 152.7°C
• Density: 1.432g/cm³
• Vapor Pressure: 0.000185mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 5-bromobiphenyl-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromobiphenyl-2-amine(5455-13-0)
• EPA Substance Registry System: 5-bromobiphenyl-2-amine(5455-13-0)

Safety Data

• Hazardous Substances Data: 5455-13-0(Hazardous Substances Data)

Usage

General Description

5-Bromobiphenyl-2-amine, also known as 2-Amino-5-bromobiphenyl, is a chemical compound that consists of a biphenyl core with a bromine atom at the 5-position and an amine group at the 2-position. It is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical has potential applications in organic synthesis, medicinal chemistry, and material science. 5-Bromobiphenyl-2-amine is a valuable building block for the preparation of various biologically active compounds and is known for its role as a versatile starting material in the synthesis of diverse chemical products. However, it is important to handle this compound with care, as it may pose health and environmental risks if not properly managed.

Upstream product

• 90-41-5 2-phenylaniline 
• 56-23-5 tetrachloromethane 
• 7726-95-6 bromine 
• 20244-61-5 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one 
• 66416-72-6 4-bromo-2-iodoaniline 
• 98-80-6 phenylboronic acid 
• 615-36-1 2-bromoaniline 
• 100-63-0 phenylhydrazine 
• 106-40-1 4-bromo-aniline 
• 51686-78-3 2,4-dibromonitrobenzene 
• 591-50-4 iodobenzene 
• 106736-41-8 N-biphenyl-2-yl-N-bromo-acetamide 
• 860572-11-8 N-biphenyl-2-yl-N-chloro-acetamide 
• 2113-47-5 2-acetamidobiphenyl 

Downstream Products

• 27353-48-6 2-bromo-phenanthridin-6-ol 
• 211621-38-4 N-(5-bromo-biphenyl-2-yl)-toluene-4-sulfonamide 
• 857534-25-9 4-bromo-benzoic acid-(5-bromo-biphenyl-2-ylamide) 
• 27353-48-6 2-bromo-6-(5H)-phenanthridinone 
• 7511-41-3 2-benzamido-5-bromobiphenyl 
• 4510-78-5 5-bromo-2-iodo-1,1'-biphenyl 
• 917381-61-4 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine 
• 16372-95-5 2.4-Dibrom-6-phenylanilin 
• 92059-22-8 3.5-Dibrom-2-azidobiphenyl 
• 1592-95-6 3-bromo-9H-carbazole 
• 855348-90-2 6-(4-ethoxycarboximidoyl-phenyl)-phenanthridine-2-carbonimidic acid ethyl ester 
• 855352-51-1 6-(4-cyano-phenyl)-phenanthridine-2-carbonitrile 
• 855348-66-2 2-bromo-6-(4-bromo-phenyl)-phenanthridine 
• 2113-57-7 3-bromobiphenyl 

Relevant articles and documents

LIPOXYGENASE INHIBITORS

Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.

Visible-light-promoted intramolecular C-H amination in aqueous solution: Synthesis of carbazoles

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K, were synthesized efficiently with nitrogen as a sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry.