5455-13-0

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromobiphenyl-2-amine is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of new medicinal compounds with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 5-bromobiphenyl-2-amine is utilized as a precursor in the production of pesticides and other crop protection agents, contributing to the development of more effective and targeted agricultural chemicals.
Used in Organic Synthesis:
5-Bromobiphenyl-2-amine is employed as a versatile building block in organic synthesis, enabling the creation of a wide range of organic compounds with diverse applications in various industries.
Used in Medicinal Chemistry:
As a key component in medicinal chemistry, 5-bromobiphenyl-2-amine is used for the design and synthesis of new pharmaceutical agents, potentially leading to the discovery of novel treatments for various diseases and conditions.
Used in Material Science:
In the field of material science, 5-bromobiphenyl-2-amine is utilized in the development of new materials with specific properties, such as improved conductivity, stability, or reactivity, for use in various applications, including electronics, coatings, and adhesives.

Upstream product

• 90-41-5 2-phenylaniline 
• 56-23-5 tetrachloromethane 
• 7726-95-6 bromine 
• 86-00-0 2-nitrobiphenyl 
• 20244-61-5 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one 
• 66416-72-6 4-bromo-2-iodoaniline 
• 98-80-6 phenylboronic acid 
• 615-36-1 2-bromoaniline 
• 100-63-0 phenylhydrazine 
• 106-40-1 4-bromo-aniline 
• 51686-78-3 2,4-dibromonitrobenzene 
• 591-50-4 iodobenzene 
• 106736-41-8 N-biphenyl-2-yl-N-bromo-acetamide 
• 860572-11-8 N-biphenyl-2-yl-N-chloro-acetamide 

Downstream Products

• 27353-48-6 2-bromo-phenanthridin-6-ol 
• 857534-25-9 4-bromo-benzoic acid-(5-bromo-biphenyl-2-ylamide) 
• 27353-48-6 2-bromo-6-(5H)-phenanthridinone 
• 7511-41-3 2-benzamido-5-bromobiphenyl 
• 4510-78-5 5-bromo-2-iodo-1,1'-biphenyl 
• 917381-61-4 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine 
• 16372-95-5 2.4-Dibrom-6-phenylanilin 
• 92059-22-8 3.5-Dibrom-2-azidobiphenyl 
• 1592-95-6 3-bromo-9H-carbazole 
• 855348-90-2 6-(4-ethoxycarboximidoyl-phenyl)-phenanthridine-2-carbonimidic acid ethyl ester 
• 855352-51-1 6-(4-cyano-phenyl)-phenanthridine-2-carbonitrile 
• 855348-66-2 2-bromo-6-(4-bromo-phenyl)-phenanthridine 
• 211621-38-4 N-(5-bromo-biphenyl-2-yl)-toluene-4-sulfonamide 
• 2113-57-7 3-bromobiphenyl 

Relevant academic research and scientific papers

LIPOXYGENASE INHIBITORS

Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.

LIPOXYGENASE INHIBITORS

Various embodiments of the present disclosure are directed to compounds having Formula I, Formula II, Formula IIA, Formula III, Formula IIIA, Formula IIIB, and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases and/or treating associated diseases. In some embodiments, subject compounds are used to prepare a composition that is effective in treating neurodegenerative diseases.

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.

Visible-light-promoted oxidative halogenation of (hetero)arenes

Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g.aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.

Visible-light-promoted intramolecular C-H amination in aqueous solution: Synthesis of carbazoles

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K, were synthesized efficiently with nitrogen as a sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry.

Metal-Oxidant-Free Cobalt-Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines: An Approach toward Free (NH)-Phenanthridinones

A traceless directing group assisted Co-catalyzed C(sp2)-H carbonylation of ortho-arylanilines for the synthesis of free (NH)-phenanthridinones in metal-based-oxidant-free fashion was accomplished. This protocol employs diisopropyl azodicarboxylate as the CO source and oxygen as the sole oxidant, and provides good yields with various functional tolerance. The methodology has been applied for the total synthesis of PARP inhibitor PJ-34. Furthermore, the kinetic isotopic effect experiments reveal the C-H bond cleavage probably occurred in the rate-determining step.

Compositions with triarylamine derivatives and oled device containing the same

The present disclosure provides a composition. In an embodiment, a composition is provided and comprises a Compound 1 shown below: For Compound 1, R1 through R24 are the same or different. R1 through R24 each is independently selected from the group consisting of hydrogen, unsubstituted hydrocarbyl, substituted hydrocarbyl, cyano, alkoxy, aryloxy, and NR'2. R' is hydrogen or hydrocarbyl; wherein two or more of adjacent R1 to R24 may optionally form one or more ring structures. The Component Z is selected from the group consisting Group Z-1, Group Z-2, Group Z-3, Group Z-4, Group Z-5, Group Z-6 and Group Z-7 shown below: For Compound 1, one or more hydrogen atoms may optionally be substituted with deuterium.

NEW CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITY

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Concise synthesis of 3D π-extended polyphenylene cylinders

The synthesis of structurally well-defined, monodisperse carbon nanotube (CNT) sidewall segments poses a challenge in materials science. The synthesis of polyphenylene cylinders that comprise typical benzene connectivity to resemble precursors of [9,9] an

Air-promoted direct radical arylation of anilines with arylhydrazines

Air-promoted coupling reaction of arylhydrazines and arylamines is developed for the selective synthesis of 2-aminobiaryls. This protocol provides a green, cost-effective, and scale-up method for preparation of 2-aminobiaryls.