54963-40-5

Upstream product

• 58085-33-9 α-phenylcinnamoyl chloride 
• 650605-38-2 4,5-diphenyl-3-oxo-4-pentenoic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 103-79-7 1-phenyl-acetone 
• 15341-31-8 α-nitro-stilbene 
• 79999-05-6 2-methyl-4-phenyl-4-(2,3-diphenyl-1-methyl-2-cyclopropen-1-yl)-Δ²-oxazolin-5-one 
• 1483-72-3 diphenyliodonium chloride 
• 1247-08-1 Triphenyl-phenylethynyl-stannane 
• 75-36-5 acetyl chloride 
• 22965-96-4 (Z)-3-bromo-4-phenyl-3-buten-2-one 
• 98-80-6 phenylboronic acid 
• 53973-14-1 (Z)-3-chloro-4-phenyl-3-buten-2-one 
• 1896-62-4 (E)-benzalacetone 
• 501-65-5 diphenyl acetylene 

Downstream Products

• 102663-29-6 1t,2-diphenyl-5-piperidino-pent-1-en-3-one 
• 70338-42-0 (E)-3,4-diphenylbut-3-en-2-ol 
• 15830-82-7 E-2-acetyl-2,3-diphenyloxirane 
• 74964-34-4 (E)-3-tert-butyl-1,2-diphenyl-1,3-butadiene 
• 87870-45-9 3,4,5,6-Tetraphenyl-octane-2,7-dione 
• 87870-48-2 1-Benzyl-4-(3-oxo-1,2-diphenyl-butyl)-1,4-dihydro-pyridine-3-carboxylic acid amide 
• 67146-57-0 1,1'-dibenzyl-1,4,1',4'-tetrahydro-[4,4']bipyridinyl-3,3'-dicarboxylic acid diamide 
• 156047-71-1 3-Hydroxy-3-((E)-2-oxo-3,4-diphenyl-but-3-enyl)-1,3-dihydro-indol-2-one 
• 89809-74-5 2-(3-Oxo-1,2-diphenyl-butyl)-malononitrile 
• 27363-82-2 α-Acetoxymethylencarbonyl-stilben 
• 70974-73-1 1-nitro-1,2-diphenyl-1-butene-3-one 
• 120638-24-6 3-methyl-1,4,5-triphenyl-1H-pyrazole 
• 156047-77-7 3-[(E)-2-Oxo-3,4-diphenyl-but-3-en-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 156047-83-5 3-((E)-2-Oxo-3,4-diphenyl-but-3-enyl)-1,3-dihydro-indol-2-one 

Relevant academic research and scientific papers

Stereoselective Synthesis of Stannyl Enones via Palladium-Catalyzed and Free Radical Hydrostannation of Alkynyl Ketones with Trineophyltin Hydride

A study on the addition of trineophyltin hydride (1) to alkynones under free radical (AIBN and Et3B) and palladium-catalyzed [(PPh3) 2PdCl2] conditions is reported. The results obtained indicate that the addition of 1 to eight ynones catalyzed by bis(triphenylphosphine)palladium(II) chloride led in all cases to addition products in very high yields (80-96%). These additions take place with excellent regio- and stereochemistry, leading to the α adducts as major products in seven out of the eight cases studied. Also the E adducts, resulting from a syn attack, were the only (seven cases) or the predominant (one case) products. The radical hydrostannations initiated by AIBN of ynones 2-5 with 1 led to addition products in good yields (60-88%); with the more hindered ketones 6 and 7-9 the yields obtained were lower. The radical additions initiated by triethylboron to ynones 2-6 follow a similar pattern but with lower yields; no addition products in the hydrostannation of ynones 7-9 were detected. The new acyl-substituted vinylstannanes, owing to their greater stability compared with that of their tributyl- and trimethylstannyl analogues, can be purified by column chromatography using neutral alumina (in all cases) or silica gel 60 (in most cases) as adsorbents. Full 1H, 13C, and 119Sn NMR data are given.

Stereospecific Decarboxylative Nazarov Cyclization Mediated by Carbon Dioxide for the Preparation of Highly Substituted 2-Cyclopentenones

Highly substituted 2-cyclopentenones were stereospecifically and regioselectively constructed with high catalytic efficiency through Lewis-acid catalyzed decarboxylative Nazarov cyclization of the cyclic carbonate derivative, which is prepared by reacting the propargyl alcohol with carbon dioxide in the presence of a silver catalyst. The stereochemistry of the 2-cyclopentenone is strictly controlled by the geometry of the alkene in the starting material. This method is applicable for various substrates.

Acid-catalyzed synthesis of α,β-disubstituted conjugated enones by a Meyer-Schuster-type rearrangement in allenols

A novel, direct and simple methodology to gain access to α,β-disubstituted conjugated enones from α-allenols in a sustainable metal catalysis context, considering the inexpensiveness and environmentally friendliness of iron(III) species and protons, has b

Copper-catalyzed regio- and stereoselective intermolecular three-component oxyarylation of allenes

A copper(II)-catalyzed intermolecular three-component oxyarylation of allenes using arylboronic acids as a carbon source and TEMPO as an oxygen source is described. The reaction proceeded under mild conditions with high regio- and stereoselectivity and functional group tolerance. A plausible reaction mechanism is proposed, involving carbocupration of allenes, homolysis of the intervening allylcopper(II), and a radical TEMPO trap.

Synthesis and antimicrobial evaluation of some pyrazole derivatives

Reaction of a series of (E)-3-phenyl-4-(p-substituted phenyl)-3-buten-2- ones with p-sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the ot

Iridium-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones: Enantioselective total synthesis of (-)-mesembrine

A highly efficient asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones catalyzed by chiral spiro iridium complexes for the preparation of chiral 2-substituted allylic alcohols has been developed (ee up to 99.7%). This method provides a concise route to (-)-mesembrine (34% yield, 12 steps).

Addition of arylboronic acids to arylpropargyl alcohols en route to indenes and quinolines

A regio- and stereoselective rhodium-catalyzed synthesis of trisubstituted allylic alcohols is described. The utility of these synthons is demonstrated in a convenient synthesis of indenes and quinolines.

Palladium-catalyzed oxidative cross-coupling reaction of arylboronic acids with diazoesters for stereoselective synthesis of (E)-α,β- diarylacrylates

A Pd-catalyzed oxidative cross-coupling reaction of arylboronic acids with α-diazoesters was achieved using molecular oxygen as the sole reoxidant, and E-α,β-diarylacrylates were obtained in good yields and >20:1 E-to-Z selectivity.

CuH-catalyzed enantioselective 1,2-reductions of α,β-unsaturated ketones

The first study on a general technology for arriving at valued nonracemic allylic alcohols using asymmetric ligand-accelerated catalysis by copper hydride is described.

A nonsymmetric pincer-catalyzed Suzuki-Miyaura arylation of benzyl halides and other nonactivated unusual coupling partners

(Chemical Equation Presented) The catalytic activity of a PCN-type palladium pincer complex is evaluated in the construction of C(sp 2)-C(sp2) and C(sp2)-C(sp3) bonds by Suzuki-Miyaura cross-couplings employing nontypical substrates such as benzyl halides, α-haloenones, or alkylboronic acids as coupling partners. Most of the reported reactions are achieved in aqueous media, with all of the advantages implied.