62573-86-8

Basic information

• Product Name: 1H-Benzimidazole, 1-benzoyl-
• Synonyms: benzimidazolyl phenyl ketone;1-benzoylbenzimidazole;N-benzoylbenzimidazole;N-benzylbenzimidazole;1H-Benzimidazole,1-benzoyl;1-Phenylbenzimidazole deriv. 5;1-benzoylbenzimidiazole;1-benzoyl-1H-benzimidazole;1-Benzoyl-1H-benzimidazol
• CAS NO: 62573-86-8
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• Mol File: 62573-86-8.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 1-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 1-benzoyl-(62573-86-8)
• EPA Substance Registry System: 1H-Benzimidazole, 1-benzoyl-(62573-86-8)

Safety Data

• Hazardous Substances Data: 62573-86-8(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 51-17-2 benzoimidazole 
• 98-88-4 benzoyl chloride 
• 613-90-1 benzoyl cyanide 
• 131195-65-8 1-benzoylamino-2-(benzoyl-formyl-amino)-benzene 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 93-97-0 benzoic acid anhydride 
• 79352-12-8 N-[(2-nitrobenzene)sulfenyl]benzimidazole 
• 24197-72-6 S-(2-nitrophenyl)benzenecarbothiolate 
• 65-85-0 benzoic acid 
• 31892-41-8 N-cyano-benzimidazole 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 861605-65-4 1,3-dibenzoyl-2,3-dihydro-1H-benzimidazol-2-ol 
• 93-55-0 1-phenyl-propan-1-one 
• 744-38-7 1,2-dibenzamidobenzene 
• 131195-65-8 1-benzoylamino-2-(benzoyl-formyl-amino)-benzene 
• 1671-75-6 Heptanophenone 
• 104057-83-2 1,3-diphenyl 9-benzoyl-1H,9H-1,2,4-triazolo<4,3-a>benzimidazole 
• 2306-61-8 1,3-dibenzoyl-1,3-dihydro-benzoimidazol-2-one 
• 93-98-1 N-phenyl benzoyl amide 
• 51-17-2 benzoimidazole 
• 64-19-7 acetic acid 
• 1704-14-9 4-hydroxy-4-phenylbut-3-en-2-one 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 65-85-0 benzoic acid 
• 2005-08-5 4-chlorophenyl benzoate 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

An Efficient Catalytic Amidation of Esters Promoted by N-Heterocyclic Carbenes

An efficient NHC-catalyzed amidation between esters and amines or hydrazines is described. This strategy was tolerant for a wide scope of substrates, affording a series of amides (or hydrazides) in good to excellent yields (60-96%) under simple conditions. The approach was also used to synthesize the pharmaceutically relevant antidepressant moclobemide in 85% yield.

Synthesis and antimicrobial activity of some benzimidazole and 2-methylbenzimidazole derivatives

In the present work, benzimidazole and 2-methylbenzimidazole derivatives were synthesized and evaluated for antimicrobial activity against Escherichia coli (Gram-negative bacteria), Staphylococcus aureus (Gram-positive bacteria) and Candida albicans (fungal stain). The structure of the synthesized compounds was confirmed by FTIR, 1H NMR and mass spectroscopy. Antimicrobial activity of all the synthesized compounds was carried out by Broth dilution method to determine MIC value. Compounds P2, P7 and P10 showed better antibacterial activity against Escherichia coli as compared to benzimidazole, 2-methylbenzimidazole and ampicillin. Compounds P8 and P12 showed better antibacterial activity against Staphylococcus aureus as compared to benzimidazole, 2-methylmenzimidazole and ampicillin. Compound P2 and P9 showed better antifungal activity against Candida albicans as compared to benzimidazole, 2-methylbenzimidazole and griseofulvin.