56074-58-9

Upstream product

• 102599-13-3 phenyl-di-p-tolyl-acetaldehyde 
• 68668-90-6 Di-p-tolyl-acetylchlorid 
• 2674-04-6 diphenyl cadmium 
• 122135-80-2 2-phenyl-1,1-di-p-tolyl-ethane-1,2-diol 
• 144-62-7 oxalic acid 
• 6425-12-3 1-phenyl-2,2-dimorpholin-1-yl-ethanone 
• 108-88-3 toluene 
• 24686-79-1 4,4'-dimethyl-thiobenzophenone S-oxide 
• 36038-92-3 N-(4-nitrobenzyl)benzimidoyl chloride 
• 7664-93-9 sulfuric acid 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 62573-86-8 N-benzoylbenzimidazole 
• 4358-87-6 (RS)-methyl mandelate 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 103269-60-9 4-nitro-benzoic acid-(1-phenyl-2,2-di-p-tolyl-ethyl ester) 
• 4957-14-6 4,4'-dimethyldiphenylmethane 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Palladium-catalyzed denitrative α-arylation of ketones with nitroarenes

The palladium-catalyzed α-arylation of ketones with readily available nitroarenes and nitroheteroarenes provides access to useful α-aryl and α-heteroaryl ketones. The use of the Pd/ BrettPhos catalysts was critical to achieve high efficiency for these transformations, whereas other catalysts led to decreased yields or no conversions. The intramolecular type substrate was also applied in this methodology and gave a chromone derivative. Polyaromatic carbonyl compounds can be easily obtained by multicomponent tandem reactions, via nucleophilic aromatic substitution (SNAr) or cross-coupling reaction followed by this denitrative arylation. Kinetic experiments show that the electronic effect of nitrobenzenes has a greater effect on the reaction rate than the electronic effect of ketones.

PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.

Facile one-pot palladium-catalyzed sequential coupling to diarylmethanes by using aryl methyl ketones as the methylene donors

A novel palladium-catalyzed coupling reaction of an aryl methyl ketone with two molecules of an aryl halide to yield symmetric diarylmethanes is described. In the facile one-pot reaction, the aryl methyl ketone acts as a formal methylene donor. The experimental facts, including TLC monitoring, speculated intermediates as the raw materials, analysis of the cesium benzoate coproduct by ex situ IR spectroscopy, and the cross-coupling reactions of two different aryl halides, indicate a mechanism involving a palladium-catalyzed sequential two-step coupling process, in which the presence of a trace amount of H 2O is indispensable. The reaction is applicable to a broad spectrum of substrates and delivers the products in good to excellent yields. Access to unsymmetrical diarylmethanes with this method is also explored and various factors are discussed. An aryl methyl ketone is used as the methylene donor to couple with two molecules of an aryl halide for the synthesis of various symmetric diarylmethanes under palladium catalysis. The mechanism involves a two-step coupling process in which the presence of a trace amount of H 2O is indispensable. The cross-coupling to unsymmetrical diarylmethanes with this method is also explored. Copyright

Direct copper-catalyzed α-arylation of benzyl phenyl ketones with aryl iodides: Route towards tamoxifen

No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups. Copyright

Palladium-catalyzed synthesis of diarylmethanes: Exploitation of carbanionic leaving groups

A novel route to the synthesis of diarylmethanes via a Pd-catalyzed α-arylation of benzyl ketones is rseported. By harnessing the inherent reactivity of enolates, it is possible to circumvent the need for a transmetalating reagent such as boron for the co

Reductive cross-coupling between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4

The reductive cross-coupling reaction between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4 was performed in refluxing THF under a nitrogen atmosphere, to give 1,2,2-triaryl ethanones in moderate to good yields.