Highly stereoselective synthesis of β-lactams by condensation of the titanium enolate of a chiral 2-pyridylthioester with chiral imines

Article abstract of DOI:10.1016/0040-4020(95)00574-R

The reaction of the titanium enolate of a 2-pyridylthioester derived from (R)-3-hydroxybutyric acid with chiral imines affords 3,3'-anti-3,4-trans configurated β-lactams in a highly selective fashion. The methodology has been applied to the synthesis of a