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Usage

Uses

Used in Pharmaceutical Industry:
M-Chloropropylbenzene serves as a crucial intermediate in the production of pharmaceuticals, contributing to the synthesis of a range of medicinal compounds. Its chemical properties make it a versatile building block for developing new drugs and enhancing existing ones.
Used in Agricultural Chemical Industry:
In the agricultural sector, M-Chloropropylbenzene is utilized in the creation of agricultural chemicals, including pesticides and herbicides. Its role in these applications is pivotal for enhancing crop protection and ensuring agricultural productivity.
Used as a Solvent:
M-Chloropropylbenzene's solvent properties are harnessed in various industrial processes, where it aids in dissolving other substances, facilitating chemical reactions, and improving the efficiency of manufacturing operations.
Used in Organic Compound Synthesis:
Beyond its direct applications, M-Chloropropylbenzene is an essential intermediate in the synthesis of other organic compounds, expanding its utility across a broad spectrum of chemical applications and industries.

Upstream product

• 34841-35-5 3'-chloro-propiophenone 
• 2234-82-4 1-propylmagnesium chloride 
• 541-73-1 1,3-Dichlorobenzene 
• 187737-37-7 propene 
• 108-90-7 chlorobenzene 
• 93-55-0 1-phenyl-propan-1-one 
• 1197-05-3 1-(3-amino-phenyl)-propan-1-one 
• 17408-16-1 3'-nitropropiophenone 

Downstream Products

• 912552-15-9 cis-(1S,2R)-1,2-dihydroxy-5-chloro-3-propylcyclohexa-3,5-diene 

Relevant academic research and scientific papers

Catalytic Synthesis of “Super” Linear Alkenyl Arenes Using an Easily Prepared Rh(I) Catalyst

Linear alkyl benzenes (LAB) are global chemicals that are produced by acid-catalyzed reactions that involve the formation of carbocationic intermediates. One outcome of the acid-based catalysis is that 1-phenylalkanes cannot be produced. Herein, it is reported that [Rh(μ-OAc)(η2-C2H4)2]2 catalyzes production of 1-phenyl substituted alkene products via oxidative arene vinylation. Since C C bonds can be used for many chemical transformations, the formation of unsaturated products provides a potential advantage over current processes that produce saturated alkyl arenes. Conditions that provide up to a 10:1 linear:branched ratio have been achieved, and catalytic turnovers >1470 have been demonstrated. In addition, electron-deficient and electron-rich substituted benzenes are successfully alkylated. The Rh catalysis provides ortho:meta:para selectivity that is opposite to traditional acid-based catalysis.

Novel synthetic usage of indium compounds as catalyst: Reductive deoxygenation of aryl ketones and sec-benzylic alcohols

The combination of chlorodimethylsilane and a catalytic amount of indium compounds is effective for the deoxygenation of aryl ketones and sec-benzylic alcohols to the corresponding hydro- carbons. The combination system is so selective toward carbonyls that the functionalities such as halogen, ester, and ether tolerate the reduction conditions.

Facile Hydrodehalogenation with H2 and Pd/C Catalyst under Multiphase Conditions. 2. Selectivity and Kinetics

Hydrodehalogenation of polyhalogenated aromatics with Pd/C catalyst carried out in the presence of a quaternary onium salt follows zero-order kinetics in the substrate and first-order kinetics in the Pd/C catalyst; the related rate constants were determined for o-, m- and p-bromotoluenes, o-, m- and p-chloroalkylbenzenes (methyl, ethyl, and propyl derivatives), and other aryl halides.Reaction rates, depending on the aromatic to be reduced, may be strongly enhanced by the presence of quaternary onium salts: the isomeric chloroethylbenzenes were reduced 50 times faster when operating in the presence of Aliquat 336 (1).Also the hindered 2-chloro-m-xylene easily yielded m-xylene.The cocatalyst onium salts operate by being adsorbed on the Pd/C surface, as shown when kinetic constants are reported by varying the onium salt amount: classical Langmuir adsorption isotherms are observed.The presence of the onium salt may also influence selectivity in the reduction of isomeric aryl halides: when 1 is present, p-dichlorobenzene reacts in diethyl ether at 20 deg C, 5-fold slower than the ortho isomer; whereas the reduction rates of the two compounds are almost the same in its absence.

Selective Mono-Alkylation and Arylation of Dichlorobenzenes by Palladium-Catalyzed Grignard Cross-Coupling

Palladium(II)-phosphine complexes, especially PdCl2(dppf) where dppf stands for 1,1'-Bis(diphenylphosphino)ferrocene, are effective catalysts for the cross-coupling of Grignard reagents with dichlorobenzenes to produce selectively mono-alkylated and arylated benzenes.The addition of ligands is also effective for the cross-coupling of Grignard reagents containing a β-hydrogen(s).