583-08-4

Usage

Uses

Used in Pharmaceutical Industry:
NICOTINOYL-GLYCINE is used as a therapeutic agent for its antiproliferative properties, which can be beneficial in managing the growth of certain cells and potentially treating specific conditions.
Used in Niacin Supplementation:
As a Niacin analog, NICOTINOYL-GLYCINE is used for therapeutic purposes to supplement Niacin levels in the body, which can contribute to maintaining overall health and well-being.

InChI:InChI=1/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)

Upstream product

• 4013-72-3 nicotinoyl azide 
• 56-40-6 glycine 
• 54466-74-9 N³-((ethoxycarbonyl)-methyl)nicotinamide 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 59-67-6 nicotinic acid 
• 78348-28-4 nicotinic acid succinimidyl ester 
• 1037820-84-0 nicotinyl-glycine-tert-butyl ester 
• 98-92-0 nicotinamide 
• 79-11-8 chloroacetic acid 
• 553-53-7 Nicotinic acid hydrazide 

Downstream Products

• 124-38-9 carbon dioxide 
• 98-92-0 nicotinamide 
• 144-62-7 oxalic acid 
• 59-67-6 nicotinic acid 
• 56-40-6 glycine 
• 347184-14-9 N-{[3-(9-Chloro-3-methyl-4oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexylcarbamoyl]-methyl}-nicotinamide 
• 105959-39-5 4-((4-azidophenyl)methylene)-2-(3-pyridyl)-1,3-oxazolin-5-one 
• 606142-93-2 4-(4-azido-β-methyl-cinnamylidene)-2-(3-pyridyl)-2-oxazolin-5-one 

Relevant academic research and scientific papers

SIRT1 ACTIVATING COMPOUNDS

Provided herein are methods and compositions for preventing or treating aging, or an aging-related disorder, a disorder associated with inflammation, or for modulating an immune response in a subject in need thereof. In some embodiments, the methods comprise administering to the subject an effective amount of a compound of Formulas I-XIII.

niacine or niacinamide substituted ascorbic acid derivatives and process for their preparation

PURPOSE: An ascorbic acid derivative in which niacinamide or niacine is introduced and a method for preparing the same are provided to enhance organic solvent solubility and efficiency. CONSTITUTION: A 3-O-substituted ascorbic acid derivative is denoted by chemical formula 1. A method for preparing the 3-O-substituted ascorbic acid derivative of chemical formula 1 comprises: a step of reacting 5,6-alkylidene ascorbic acid derivative with an acid derivative of chemical formula 2 in an organic solvent; and a step of deprotecting under the presence of carbodiimide of chemical formula 4. The organic solvent is amides, sulfoxides, alcohols, ethers, ketones, halogenated hydrocarbons, or fatty acid organic acid.

Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives

Twelve novel hybrids of slowly releasing hydrogen sulfide donor ADT-OH combined with nicotinic acid were synthesized. All of their structures had been confirmed by1H NMR,13C NMR and MS spectra. The target compounds were evaluated for their neuroprotective effects on hippocampal neuron HT22 cells against glutamate-induced injury at the concentrations of 1–100?μM with MTT assay, and their toxicity on HT22 cells untreated by glutamine at the concentration of 100?μM. The active compound was further investigated for its effect on ischemic infarct volume by intraperitoneal injection at 3?h after ischemia in mice models of permanent middle cerebral artery occlusion (pMCAO). The results showed that all the compounds significantly protected HT22 cells from glutamate-induced damage at most of the experimental concentrations, and had no or little neurotoxicity on normal HT22 cells at the high concentration. More importantly, compound A6 significantly reduced infarct volume in the pMCAO model. These results suggested that compound A6 may be promising for further evaluation for the intervention of cerebral ischemic injury.

Synthesis and Quantitative Structure-activity Relationships Study for Arylpropenamide Derivatives as Inhibitors of Hepatitis B Virus Replication

A series of new arylpropenamide derivatives containing different aryl groups were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities. A new high accuracy QSAR model of arylpropenamide was constructed based on a more completely activities data and calculation parameter. The 2D-QSAR equations, by using DFT and multiple linear regression analysis methods, revealed that higher value of thermal energy (TE) and lower entropy (S?) increase the anti-HBV activities of the arylpropenamide molecules. Predictive 3D-QSAR models were established by SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.

Solid phase synthesis of acylglycine human metabolites

Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is devel

Substituted 2-imidazolin-5-ones

The present invention relates to compounds of formula I, STR1 in which R1 signifies a divalent, mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series, R2 signifies a hydrogen atom or an unsubstituted or substituted (C1-4)alkyl, phenyl, naphthyl or mono- or fused binuclear heterocyclic radical which is bound through a carbon atom, R3 signifies an oxygen atom or a group of formula >N--R5 in which R5 has one of the significances given above for R2, and each of the R4 's independently, signifies a mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series, Or mixtures of such compounds, which compounds and mixtures are useful as colorants.