59693-94-6

Basic information

• Product Name: Benzene, 1-(cyclohexylthio)-4-methoxy-
• CAS NO: 59693-94-6
• Molecular Formula: C13H18OS
• Molecular Weight: 222.351
• Mol File: 59693-94-6.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(cyclohexylthio)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(cyclohexylthio)-4-methoxy-(59693-94-6)
• EPA Substance Registry System: Benzene, 1-(cyclohexylthio)-4-methoxy-(59693-94-6)

Safety Data

• Hazardous Substances Data: 59693-94-6(Hazardous Substances Data)

Upstream product

• 1569-69-3 Cyclohexanethiol 
• 5720-07-0 4-methoxyphenylboronic acid 
• 696-62-8 para-iodoanisole 
• 50729-68-5 sodium cyclohexanethiolate 
• 696-63-9 4-Methoxybenzenethiol 
• 16156-56-2 cyclohexyl mesylate 
• 108-93-0 cyclohexanol 
• 110-82-7 cyclohexane 
• 1709-60-0 4-methoxybenzenesulfinic acid 
• 108-85-0 1-bromocyclohexane 
• 98-89-5 Cyclohexanecarboxylic acid 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 

Relevant articles and documents

Ni(II) Precatalysts Enable Thioetherification of (Hetero)Aryl Halides and Tosylates and Tandem C?S/C?N Couplings

Ni-catalyzed C?S cross-coupling reactions have received less attention compared with other C-heteroatom couplings. Most reported examples comprise the thioetherification of most reactive aryl iodides with aromatic thiols. The use of C?O electrophiles in this context is almost uncharted. Here, we describe that preformed Ni(II) precatalysts of the type NiCl(allyl)(PMe2Ar’) (Ar’=terphenyl group) efficiently couple a wide range of (hetero)aryl halides, including challenging aryl chlorides, with a variety of aromatic and aliphatic thiols. Aryl and alkenyl tosylates are also well tolerated, demonstrating, for the first time, to be competent electrophilic partners in Ni-catalyzed C?S bond formation. The chemoselective functionalization of the C?I bond in the presence of a C?Cl bond allows for designing site-selective tandem C?S/C?N couplings. The formation of the two C-heteroatom bonds takes place in a single operation and represents a rare example of dual electrophile/nucleophile chemoselective process.

Electrochemical Deoxygenative Thiolation of Preactivated Alcohols and Ketones

This work describes an electrochemically promoted nickel-catalyzed deoxygenative thiolation of alcohols and ketones under mild conditions. Excellent substrate tolerance and good chemical yields can be achieved by graphene/nickel foam electrodes in an undivided cell. Further study to gain mechanistic insight into this electrochemical cross-coupling has been carried out.

Visible-Light-Mediated Alkylation of Thiophenols via Electron Donor-Acceptor Complexes Formed between Two Reactants

A metal-free, photocatalyst-free, photochemical system was developed for the direct alkylation of thiophenols via electron donor-acceptor (EDA) complexes (KEDA = 145 M-1) between two reactants, N-hydroxyphthalimide esters as acceptors and thiophenol anions as donors, in the presence of a tertiary amine. The EDA complexes in the reaction system have a broad range of visible-light absorption (400-650 nm) and can trigger the reaction effectively under sunlight.