59749-79-0

Upstream product

• 14548-38-0 6-chloro-1-indanone 
• 108-86-1 bromobenzene 
• 102990-14-7 1-(4-chlorophenyl)-3-phenylprop-2-yn-1-ol 
• 108-90-7 chlorobenzene 
• 104-55-2 3-phenyl-propenal 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 
• 14900-39-1 phenylvinylboronic acid 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 

Downstream Products

• 21143-57-7 (2-Benzyl-4-chloro-phenyl)-acetic acid 
• 77605-68-6 7-chloro-1-phenylisochroman-3-one 
• 77948-79-9 5-chloro-2-benzoylphenylacetic acid 
• 41148-47-4 4-chloro-2-benzoylphenylacetic acid 

Relevant academic research and scientific papers

Rhodium(II)- or Copper(I)-Catalyzed Formal Intramolecular Carbene Insertion into Vinylic C(sp2)?H Bonds: Access to Substituted 1H-Indenes

A rhodium(II)- or copper(I)-catalyzed formal intramolecular carbene insertion into vinylic C(sp2)?H bonds is reported herein. This method provides straightforward access to 1H-indenes with high efficiency and excellent functional-group compatibility. Mechanistically, the reaction is proposed to involve the following sequence: metal carbene formation, intramolecular nucleophilic addition of the double bond to the electron-deficient carbene carbon atom, dearomatization, and finally a 1,5-H shift.

Synthesis of indenes via aluminum chloride-promoted tandem Friedel-Crafts alkylation of arenes and cinnamaldehydes

A series of substituted indenes were synthesized from arenes and cinnamaldehydes via aluminum chloride-promoted tandem Friedel-Crafts alkylation. The scope and limitation of the tandem reaction were explored. A plausible reaction mechanism is also discuss

Iodine/Et3SiH: A novel reagent system for the synthesis of 3-aryl-1H-indenes from 1,3-diaryl propargyl alcohols

1,3-Diaryl propargyl alcohols undergo smooth intramolecular Friedel-Crafts cyclization with triethylsilane in the presence of 10 mol % iodine 3-aryl-1H-indene derivatives in good yields in short reaction times. This is the first example on the synthesis of substituted indenes from 1,3-diaryl propargyl alcohols. The use of inexpensive and readily available molecular iodine makes this method quite simple, more convenient, and practical.

Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors

The p38 MAP kinase is a key enzyme in inflammatory diseases as it is involved in the biosynthesis of proinflammatory cytokines such as TNF-α and IL-1β. Small molecule p38 inhibitors suppress the production of these cytokines and therefore p38 is a promisi