59852-82-3

Usage

Uses

Used in Organic Synthesis:
1-(4-Benzylamino-Phenyl)-Ethanone is used as a building block in organic synthesis for creating more complex molecules. Its unique structure allows for the formation of various derivatives, making it a valuable component in the synthesis of advanced chemical compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-Benzylamino-Phenyl)-Ethanone serves as a key component in the development of new pharmaceuticals. Its reactive nature and structural versatility enable the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research and Development:
Due to its unique structure and reactivity, 1-(4-Benzylamino-Phenyl)-Ethanone is used as a reagent in various chemical reactions. This makes it a versatile compound in the field of chemical research and development, where it can contribute to the discovery of new materials and processes.
Used in Pharmaceuticals:
1-(4-Benzylamino-Phenyl)-Ethanone has potential applications in the pharmaceutical industry, where it can be utilized in the development of new drugs and therapeutic agents. Its structural diversity and reactivity make it a promising candidate for the creation of innovative pharmaceutical compounds.
Used in Agrochemicals:
In the agrochemical industry, 1-(4-Benzylamino-Phenyl)-Ethanone can be employed in the synthesis of new agrochemical products, such as pesticides and herbicides. Its unique properties allow for the development of more effective and targeted agrochemicals.
Used in Materials Science:
1-(4-Benzylamino-Phenyl)-Ethanone also has potential applications in materials science, where it can be used to create new materials with specific properties. Its versatility and reactivity make it a valuable component in the development of advanced materials for various applications.

Upstream product

• 138469-36-0 1-(4-(benzylideneamino)phenyl)ethan-1-one 
• 99-92-3 p-aminobenzophenone 
• 108-88-3 toluene 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 622-30-0 N-benzyl hydroxylalmine 
• 149104-90-5 4-acetylphenylboronic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 100-19-6 (4-nitrophenyl)ethanone 
• 538-51-2 benzylidene phenylamine 
• 99-91-2 para-chloroacetophenone 

Relevant academic research and scientific papers

METHOD FOR PREPARING BENZYL AMINE COMPOUND

Disclosed is a method for preparing a benzyl amine compound, i.e., synthesizing a benzyl amine compound by means of an oxidation reaction between a methylbenzene/ethylbenzene compound and arylamine by using an ionic iron (III) complex containing 1,3-di-tert-butylimidazolium cation and having a molecular formula of [(RNCHCHNR)CH][FeBr4] (R being tert-butyl) and di-t-butyl peroxide as an oxidant. The present invention is not only applicable to a methylbenzene compound containing a benzylic primary carbon-hydrogen bond but also applicable to an ethylbenzene compound containing a benzylic secondary carbon-hydrogen bond, and therefore is widely applicable. This is the first case where the preparation of a benzyl amine compound by means of an oxidation reaction between a methylbenzene/ethylbenzene compound and arylamine is implemented by an iron catalyst.

Iron-Catalyzed Oxidative Amination of Benzylic C(sp3)–H Bonds with Anilines

Iron-catalyzed oxidative amination of benzylic C(sp3)–H bonds with anilines bearing electron-withdrawing groups (EWGs) or electron-donating groups (EDGs) is realized based on simple variations of N-substituents on imidazolium cations in novel ionic Fe(III) complexes. The structural modification of the imidazolium cation resulted in regulation of the redox potential and the catalytic performance of the iron metal center. Using DTBP as oxidant, [HItBu][FeBr4] showed the highest catalytic activity for anilines bearing EWGs, while [HIPym][FeBr4] was more efficient for EDG-substituted anilines. This work provides alternative access to benzylamines with the advantages of both a wide substrate scope and iron catalysis.

Porous polymeric ligand promoted copper-catalyzed C-N coupling of (hetero)aryl chlorides under visible-light irradiation

A porous polymeric ligand (PPL) has been synthesized and complexed with copper to generate a heterogeneous catalyst (Cu@PPL) that has facilitated the efficient C-N coupling with various (hetero)aryl chlorides under mild conditions of visible-light irradiation at 80 °C (58 examples, up to 99% yields). This method could be applied to both aqueous ammonia and substituted amines, and is compatible to a variety of functional groups and heterocycles, as well as allows tandem C-N couplings with conjunctive dihalides. Furthermore, the heterogeneous characteristic of Cu@PPL has enabled a straightforward catalyst separation in multiple times of recycling with negligible catalytic efficiency loss by simple filtration, affording reaction mixtures containing less than 1 ppm of Cu residue. [Figure not available: see fulltext.]

Scalable preparation of stable and reusable silica supported palladium nanoparticles as catalysts for N-alkylation of amines with alcohols

The development of nanoparticles-based heterogeneous catalysts continues to be of scientific and industrial interest for the advancement of sustainable chemical processes. Notably, up-scaling the production of catalysts to sustain unique structural features, activities and selectivities is highly important and remains challenging. Herein, we report the expedient synthesis of Pd-nanoparticles as amination catalysts by the reduction of simple palladium salt on commercial silica using molecular hydrogen. The resulting Pd-nanoparticles constitute stable and reusable catalysts for the synthesis of various N-alkyl amines using borrowing hydrogen technology without the use of any base or additive. By applying this Pd-based catalyst, functionalized and structurally diverse N-alkylated amines as well as some selected drug molecules were synthesized in good to excellent yields. Practical and synthetic utility of this Pd-based amination protocol has been demonstrated by upscaling catalyst preparation and amination reactions to several grams-scales as well as recycling of catalyst. Noteworthy, this Pd-catalyst preparation has been up-scaled to kilogram scale and catalysts prepared in both small (1 g) and large-scale (kg) exhibited similar structural features and activity.

Catalyst- And solvent-free efficient access to: N -alkylated amines via reductive amination using HBpin

A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules. This journal is

Thioglycerol-Stabilized Rhodium Nanoparticles in Biphasic Medium as Catalysts in Multistep Reactions

Small rhodium nanoparticles (ca. 3.5 nm) were prepared by the decomposition of an organometallic precursor under hydrogen pressure in glycerol using 1-thioglycerol as stabilizer. Full characterization in the solid state [HR-TEM, EDX, XPS] showed a fcc structure for the Rh0/RhI nanoparticles capped with thiolate ligand. Reduction of different functionalities, including nitro groups and imines, was applied to tandem reductive amination of aldehydes with primary and secondary amines, and to the synthesis of N-substituted anilines from nitrobenzene. In addition, thiolate-capped RhNPs could be recovered and reused up to 5 runs without loss of activity nor selectivity.

Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

Method of preparing benzylamine compound

The invention discloses a method of preparing a benzylamine compound. The method comprises the following steps of by taking 1,3-di-tert-butylimidazolin cation contained ionic iron (III) complex with amolecular formula being [(RNCHCHNR)CH][FeBr4] (wherein R is a tertiary butyl group) as a catalyst and di-tert-butyl peroxide as an oxidizing agent, and performing oxidizing reaction on a methylbenzene/ethylbenzene compound and arylamine to synthesize the benzylamine compound. The method is wide in application range, is suitable for a methylbenzene compound containing benzyl-position primary carbon-hydrogen bonds and also suitable for an ethylbenzene compound containing benzyl-position secondary carbon-hydrogen bonds. The method is a first case that preparation of the benzylamine compound through oxidizing reaction of the methylbenzene/ethylbenzene compound and the arylamine is realized with an iron catalyst.

Application of ionic iron (III) complex as catalyst in preparation of benzylamine compound

The invention discloses the application of an ionic iron (III) complex as a catalyst in preparation of a benzylamine compound, that is, an ionic iron (III) complex having a formula of [(RNCHCHNR)CH][FeBr4] (R is tert-butyl) and containing 1,3-di-tert-butyl imidazolium cation is used as a catalyst, di-tert-butyl peroxide is used as an oxidizing agent, and a benzylamine compound is synthesized by oxidation reaction of a toluene/ethylbenzene compound with an aromatic amine. The application of an ionic iron (III) complex as a catalyst in preparation of a benzylamine compound has wide application range, and is applicable not only to a toluene compound containing a benzylic primary carbon-hydrogen bond but also to an ethylbenzene compound containing a benzyl secondary carbon-hydrogen bond. Thisis the first example of the preparation of a benzylamine compound by oxidation reaction of a toluene/ethylbenzene compound and an aromatic amine by an iron-based catalyst.

Chemoselective Alkylation of Aminoacetophenones with Alcohols by Using a Palladacycle-Phosphine Catalyst

The development of efficient and environmentally benign palladacycle-phosphine catalyzed process to enable the formation of chemoselective C-alkylated or N-alkylated aminoacetophenones with alcohols is described. This methodology proved to be tunable by variation of the base and the temperature, which allows for the isolation of structurally diverse C-alkylated and N-alkylated aminoacetophenones. Moreover, this methodology has been applied to the synthesis of biologically and industrially important donepezil.