60190-89-8

Upstream product

• 51463-49-1 dimethyl 1-diazo-2-phenylethylphosphonate 
• 96-36-6 methyl phosphite 
• 33142-26-6 Diethyl (1-Formyl-1-phenylmethyl)phosphonate 
• 103-64-0 bromostyrene 
• 868-85-9 Dimethyl phosphite 
• 121-45-9 phosphorous acid trimethyl ester 
• 100-52-7 benzaldehyde 
• 27491-70-9 dimethyl diazomethylphosphonate 
• 4645-32-3 dimethylvinylphosphonate 
• 71-43-2 benzene 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 
• 102-96-5 (2-nitroethenyl)benzene 
• 5153-67-3 nitrostyrene 

Downstream Products

• 133378-26-4 methyl erythro-1,2-dibromo-2-phenylethylphosphonate 
• 133378-26-4 methyl threo-1,2-dibromo-2-phenylethylphosphonate 

Relevant academic research and scientific papers

A mild electroassisted synthesis of (hetero)arylphosphonates

The electrochemically-assisted synthesis of (hetero)arylphosphonates from (hetero)aryl halides and dimethyl phosphite is described. Very mild and simple conditions are employed as the cross-coupling is carried out in galvanostatic mode, in an undivided ce

Cu(i)/Fe(III)-Catalyzed C-P cross-coupling of styrenes with H-phosphine oxides: A facile and selective synthesis of alkenylphosphine oxides and β-ketophosphonates

Cu(i)/Fe(iii)-Catalyzed phosphorylation and oxyphosphorylation of styrenes with H-phosphonates which can be controlled by varying the reaction temperature are developed. This study offers a new and expedient strategy for the synthesis of useful alkenylphosphine oxides and β-ketophosphonates in satisfactory yields. Moreover, the transformation is proposed to proceed via a radical process and exhibits a broad substrate scope and good functional group tolerance.

A (E) - 2-aryl ethylene cinnamenyl method for preparing ester derivative

The invention discloses method for preparing (E)-2-aryl vinyl phosphonate derivatives. The method comprises the specific following steps of dissolving 1-nitro-2-aryl-vinyl derivatives, a phosphorus reagent, an accelerator manganese acetate and a catalyst copper acetate in a solvent and reacting at 20-100 DEG C to obtain the (E)-2-aryl vinyl phosphonate derivatives. According to the method disclosed by the invention, the 1-nitro-2-aryl-vinyl derivatives are adopted as starting materials, the raw materials are easily available and have multiple varieties; the products obtained by the method disclosed by the invention are multiple and can be directly applied and can be also used for other further reaction; according to the method, the use of precious metal reagents and other additives is avoided; and meanwhile, the synthetic route is short, reaction conditions are mild, the reaction operation and post-treatment process are simple, the yield is high and the method is suitable for scale production.

Probing the reactivity of H-phosphonate derivatives for the hydrophosphonylation of various alkenes and alkynes under free-radical conditions

Hydrophosphonylation is an efficient process to create carbon-phosphorus bonds from unsaturated C-C bonds and to give rise to alkylphosphonate or vinylphosphonate derivatives. In this work, we report on the reactivity of H-phosphonate derivatives for the hydrophosphonylation of various alkenes and alkynes under photoinduced free-radical conditions. The reaction was carried out on activated, unactivated and/or disubstituted alkenes or alkynes with 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator under UV irradiation.

Silver-catalyzed direct regioselective phosphonation of β-aryl-α, β-unsaturated carbonyl compounds with H-phosphites under microwave irradiation

An efficient protocol for silver-catalyzed direct radical phosphonation of β-aryl-α,β-unsaturated carbonyl compounds with H-phosphites to afford trans-substituted alkenylphosphonates under microwave irradiation is described. Some notable features of this

Silver-catalyzed synthesis of 2-arylvinylphosphonates by cross-coupling of β-nitrostyrenes with: H -phosphites

An efficient protocol for stereoselective synthesis of 2-arylvinylphosphonates has been developed via AgNO3-catalyzed cross-coupling of β-nitrostyrenes with dialkyl H-phosphites under mild conditions. By losing the nitro group of β-nitrostyrene

Solvent-controlled direct radical oxyphosphorylation of styrenes mediated by Manganese(III)

Direct radical oxyphosphorylation of styrenes with diarylphosphine oxides and dialkyl phosphites mediated by Mn(OAc)3 is described. The solvent played a key role in this selective difunctionalization reaction.

Direct radical acetoxyphosphorylation of styrenes mediated by manganese(III)

Direct radical acetoxyphosphorylation of styrenes mediated by Mn(OAc)3 with diphenylphosphine oxide and dialkyl phosphites was described, and a new type of difunctionalization of alkenes was achieved.

Versatile palladium-catalyzed C-H olefination of (hetero)arenes at room temperature

The room-temperature oxidative C-H/C-H cross-couplings between (hetero)arenes and alkenes, coumarins or quinones have been reported by using a highly electrophilic palladium species [Pd(TFA)2], generated in situ from Pd(OAc)2and TFA, as the catalyst and cheap (NH4)2S2O8as the oxidant under air.

Substituent controlled reactivity switch: Selective synthesis of α-diazoalkylphosphonates or vinylphosphonates via nucleophilic substitution of alkyl bromides with Bestmann-Ohira reagent

We report a substituent controlled nucleophilic displacement of alkyl bromides with Bestmann-Ohira reagent yielding either dimethyl diazoalkylphosphonates or (E)-vinylphosphonates. The dimethyl diazoalkylphosphonates could be readily converted into corresponding (E)-vinylphosphonates in the presence of Cu following nitrogen elimination in quantitative yields. This journal is