60677-43-2

Upstream product

• 99-92-3 p-aminobenzophenone 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 103-71-9 phenyl isocyanate 
• 20062-24-2 4-azidoacetophenone 
• 6099-87-2 methyl 2,4-dinitrophenyl carbonate 
• 201230-82-2 carbon monoxide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 79-37-8 oxalyl dichloride 
• 138835-54-8 2,4,6-trinitrophenyl methyl carbonate 
• 6294-89-9 hydrazinecarboxylic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 
• 62-53-3 aniline 

Downstream Products

• 60677-44-3 3-chloro-4-methoxycarbonylaminoacetophenone 
• 87623-18-5 [4-(2-Methyl-[1,3]oxathiolan-2-yl)-phenyl]-carbamic acid methyl ester 
• 82366-45-8 4-acetyl-2,6-dinitroaniline 
• 60677-45-4 3-chloro-4-methoxycarbonylamino-α-bromoacetophenone 
• 60677-80-7 3-chloro-4-methoxycarbonylamino-α-(N-tert-butylaminomethyl)benzyl alcohol 
• 1246443-82-2 7-hydroxy-2-(4-methoxycarbonylaminophenyl)chromenium chloride 
• 1246443-78-6 methyl 4-[(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetyl]phenylcarbamate 
• 1246443-81-1 2-(4-methoxycarbonylaminophenyl)chromenium chloride 
• 1515895-89-2 methyl N-{4-[1-isonicotinoyl-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl}carbamate 
• 1515895-92-7 methyl N-{4-[2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl]phenyl}carbamate 
• 1515895-97-2 methyl N-{4-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate 
• 1515896-00-0 methyl N-{4-[5-(4-methoxyphenyl)isoxazol-3-yl]phenyl}carbamate 
• 1515895-62-1 methyl N-4-{[3-(4-methoxyphenyl)prop-2-enoyl]phenyl}carbamate 
• 1515895-85-8 ethyl N-4-{[3-(4-methoxyphenyl)prop-2-enoyl]phenyl}carbamate 

Relevant academic research and scientific papers

Reductive Carbonylation of Nitroarenes Using a Heterogenized Phen-Pd Catalyst

The reductive carbonylation of nitroarenes in the presence of MeOH and CO(g) is one of the interesting alternative routes without utilizing toxic phosgene and corrosive HCl generation for the synthesis of industrially useful carbamate compounds that serve as important intermediates for polyurethane production. Since homogeneous palladium catalysts supported by phen (phen = 1,10-phenanthroline) are known to be effective for this catalysis, the heterogenized Pd catalyst was developed using the phen-containing solid support. In this study, we report the synthesis of a phen-based heterogeneous Pd catalyst, Pd@phen-POP, which involves the solvent knitting of a phen scaffold via the Lewis-acid-catalyzed Friedel-Crafts reaction using dichloromethane as a source for linker in the presence of AlCl3 as a catalyst. The resulting solid material has been thoroughly characterized by various physical methods revealing high porosity and surface area. Similar to the homogeneous pallidum catalyst, this heterogeneous catalyst shows efficient reductive carbonylation of various nitroarenes. The catalytic reaction using nitrobenzene as a model compound presents a high turnover number (TON = 530) and a reasonable turnover frequency (TOF = 45 h-1), with a high selectivity (92%) for the carbamate formation. According to the recycling study, the heterogeneous catalyst is recyclable and retains ～90% of the original reactivity in each cycle.

Copper-Catalyzed Coupling of Amines with Carbazates: An Approach to Carbamates

A new approach for the preparation of carbamatesviathe copper-catalyzed cross-coupling reaction of amines with alkoxycarbonyl radicals generated from carbazates is described. This environmentally friendly protocol takes place under mild conditions and is compatible with a wide range of amines, including aromatic/aliphatic and primary/secondary substrates.

Arylaminopropanone derivatives as potential cholinesterase inhibitors: Synthesis, docking study and biological evaluation

Neurodegenerative diseases in which the decrease of the acetylcholine is observed are growing worldwide. In the present study, a series of new arylaminopropanone derivatives with N-phenylcarbamate moiety (1-16) were prepared as potential acetylcholinesterase and butyrylcholinesterase inhibitors. In vitro enzyme assays were performed; the results are expressed as a percentage of inhibition and the IC50 values. The inhibitory activities were compared with reference drugs galantamine and rivastigmine showing piperidine derivatives (1-3) as the most potent. A possible mechanism of action for these compounds was determined from a molecular modelling study by using combined techniques of docking, molecular dynamics simulations and quantum mechanics calculations.

CuSe2/CeO2 as a novel heterogeneous catalyst for reductive carbonylation of nitroarenes for generating urethanes

The reaction of CuCl2, SeO2, and cetyltrimethylammonium bromide (CTAB) under the CO pressure in methanol produce a black solid, which is identified as cupric diselenide, CuIISe2 using various spectroscopic analyses. Impregnation of 5 wt% of CuSe2 onto CeO2 resulted in much more enhanced catalytic activity due to the uniform and highly dispersed particle. The reductive carbonylation of nitrobenzene (NB) as a model substrate has been examined in the presence of the CuSe2/CeO2 as a single component heterogeneous catalyst, which is found to exhibit excellent catalytic activity for generating methyl-N-phenyl carbamate (MPC) in a highly selective fashion. The effects of various reaction parameters such as temperature, pressure, and reaction time have been investigated. A plausible reaction mechanism using this cheap heterogeneous catalyst is also presented, especially invoking the importance of CuSe2(μ-CO) species.

Synthesis and in vitro antimycobacterial activity of novel n-arylpiperazines containing an ethane-1,2-diyl connecting chain

Novel 1-(2-{3-/4-[(alkoxycarbonyl)amino]phenyl}-2-hydroxyethyl)-4-(2-fluorophenyl)-piperazin-1-ium chlorides (alkoxy = methoxy to butoxy; 8a-h) have been designed and synthesized through multistep reactions as a part of on-going research programme focused

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

N-Methylation of poorly nucleophilic aromatic amines with dimethyl carbonate

Abstract: Dimethyl carbonate (DMC), an environmentally friendly methylation agent, is a substitute for traditional methylation agents such as methyl halides (CH3X, X?=?I, Br, Cl) or dimethyl sulfate. An efficient, convenient, and green method has been developed for N-methylation of poorly nucleophilic aromatic amines with DMC. It was found that the couple PEG400/K2CO3 provides good selectivity for the N-methylation product. Finally, the mechanism for reaction of amines with DMC was investigated, and a plausible multistep mechanism proposed and verified. Graphical Abstract: [Figure not available: see fulltext.]

Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors

In this study, we developed 3-/4-aminoacetophenones and their structure-based 3-/4-aminophenylethylidenethiosemicarbazide derivatives, respectively, as novel tyrosinase activators and inhibitors. Notably, all the obtained thiosemicarbazones displayed more potent tyrosinase inhibitory activities than kojic acid. Especially, compound 7k was found to be the most active tyrosinase inhibitor with IC50 value of 0.291 1/4M. The structure-activity relationships (SARs) analysis showed that: (1) the amine group was absolutely necessarily for determining the tyrosinase activation activity; (2) the introduction of thiosemicarbazide group played a very vital role in transforming tyrosinase activators into tyrosinase inhibitors; (3) the phenylethylenethiosemicarbazide moiety was crucial for determining the tyrosinase inhibitory activity; (4) the type of acyl group had no obvious effect on the inhibitory activity; (5) the position of amide substituent on the phenyl ring influenced the tyrosinase inhibitory potency. Moreover, the inhibition mechanism and inhibition kinetics study revealed that compound 7k was reversible and non-competitive inhibitor, and compound 8h was reversible and competitive-uncompetitive mixed-II type inhibitor.

Palladium-catalyzed carbonylation of amines: Switchable approaches to carbamates and N,N′-disubstituted ureas

Switchable access to carbamates and ureas has been developed by solvent control palladium-catalyzed carbonylation of aromatic amines under an atmosphere of carbon monoxide. A variety of N-phenylcarbamates and N,N′- diphenylureas was easily synthesized in good to excellent yields from readily available aromatic amines under mild conditions. Copyright