60677-43-2Relevant articles and documents
Reductive Carbonylation of Nitroarenes Using a Heterogenized Phen-Pd Catalyst
Padmanaban, Sudakar,Ganesan, Vinothkumar,Yoon, Sungho,Lee, Yunho
, p. 1552 - 1561 (2022/01/27)
The reductive carbonylation of nitroarenes in the presence of MeOH and CO(g) is one of the interesting alternative routes without utilizing toxic phosgene and corrosive HCl generation for the synthesis of industrially useful carbamate compounds that serve as important intermediates for polyurethane production. Since homogeneous palladium catalysts supported by phen (phen = 1,10-phenanthroline) are known to be effective for this catalysis, the heterogenized Pd catalyst was developed using the phen-containing solid support. In this study, we report the synthesis of a phen-based heterogeneous Pd catalyst, Pd@phen-POP, which involves the solvent knitting of a phen scaffold via the Lewis-acid-catalyzed Friedel-Crafts reaction using dichloromethane as a source for linker in the presence of AlCl3 as a catalyst. The resulting solid material has been thoroughly characterized by various physical methods revealing high porosity and surface area. Similar to the homogeneous pallidum catalyst, this heterogeneous catalyst shows efficient reductive carbonylation of various nitroarenes. The catalytic reaction using nitrobenzene as a model compound presents a high turnover number (TON = 530) and a reasonable turnover frequency (TOF = 45 h-1), with a high selectivity (92%) for the carbamate formation. According to the recycling study, the heterogeneous catalyst is recyclable and retains ～90% of the original reactivity in each cycle.
Arylaminopropanone derivatives as potential cholinesterase inhibitors: Synthesis, docking study and biological evaluation
Cs?llei, Jozef,Enriz, Daniel,Garro, Adriana D.,Gutierrez, Lucas J.,Hudcová, Anna,Kroutil, Ale?,Kubínová, Renata,Oravec, Michal
, (2020/04/17)
Neurodegenerative diseases in which the decrease of the acetylcholine is observed are growing worldwide. In the present study, a series of new arylaminopropanone derivatives with N-phenylcarbamate moiety (1-16) were prepared as potential acetylcholinesterase and butyrylcholinesterase inhibitors. In vitro enzyme assays were performed; the results are expressed as a percentage of inhibition and the IC50 values. The inhibitory activities were compared with reference drugs galantamine and rivastigmine showing piperidine derivatives (1-3) as the most potent. A possible mechanism of action for these compounds was determined from a molecular modelling study by using combined techniques of docking, molecular dynamics simulations and quantum mechanics calculations.
Synthesis and in vitro antimycobacterial activity of novel n-arylpiperazines containing an ethane-1,2-diyl connecting chain
Gonec, Tomás,Malík, Ivan,Cs?llei, Jozef,Jampílek, Josef,Stolaríková, Jirina,Solovic, Ivan,Miku, Peter,Keltoová, Stanislava,Kollár, Peter,O'Mahony, Jim,Coffey, Aidan
, (2018/01/17)
Novel 1-(2-{3-/4-[(alkoxycarbonyl)amino]phenyl}-2-hydroxyethyl)-4-(2-fluorophenyl)-piperazin-1-ium chlorides (alkoxy = methoxy to butoxy; 8a-h) have been designed and synthesized through multistep reactions as a part of on-going research programme focused
