613-35-4Relevant articles and documents
Symmetric bis-benzimidazoles: New sequence-selective DNA-binding molecules
Neidle, Stephen,Mann, John,Rayner, Emma L.,Baron, Anne,Opoku-Boahen, Yaw,Simpson, Ian J.,Smith, Nicola J.,Keith R, Fox,Hartley, John A.,Kelland, Lloyd R.
, p. 929 - 930 (1999)
A series of bis-benzimidazole compounds with a head-to-head orientation have been designed as sequence-specific DNA binders; crystallographic analysis of oligonucleotide complexes has been combined with DNase I footprinting to confirm that the predicted optimal site for the core bisbenzimidazole motif is the four-base-pair sequence 5'-AATT; this sequence specificity results in inhibition of transcription at A/T sites and may be responsible for the cytotoxic and antitumour effects shown by these head-to-head bis-benzimidazoles.
Eco-friendly, catalyst and solvent-free, synthesis of acetanilides and N-benzothiazole-2-yl-acetamides
Cunha, Silvio,De Santana, Louren?o L. B.
, p. 1137 - 1144 (2017/05/01)
An expeditious and green synthesis of acetamides in a solvent-free simple way is described, without catalyst or additives, and in good yield by an instantaneous reaction of anilines or 2-aminothiazoles and acetic anhydride without external heating, and with simple purification. Sixteen substituted acetanilides and four N-benzothiazole-2-yl-acetamides were formed, but aliphatic amines of low molecular weight were not as effective as aromatic ones, and only cyclohexylamine and the enaminone ethyl 3-amino-2-butenoate afforded the corresponding acetamides in good yield.
Pd(OAc)2/PPh3-catalyzed desulfonylative homocoupling of arylsulfonyl chlorides
Zhao, Qiao,Chen, Liangshun,Lang, Hongyue,Wu, Shengying,Wang, Limin
, p. 535 - 538 (2015/05/27)
The Pd-catalyzed homodimerization with respect to arylsulfonyl chlorides as an efficient method for the synthesis of biaryls has been developed. This desulfonylative reaction which was performed at reflux in 1,4-dioxane for 4 h under air afforded the desired products in good to excellent yields. The Pd(OAc)2/PPh3-catalyzed desulfonylative homodimerization of arenesulfonyl chlorides as an efficient method for the synthesis of biaryls was described. The corresponding products were obtained in good to excellent yields.
