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Usage

Uses

Used in Pharmaceutical Industry:
trans-[2-BroMoMethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]Methyl Benzoate is used as an intermediate in the preparation of antifungal agents for the treatment of various fungal infections. Its unique molecular structure allows it to be a key component in the synthesis of effective antifungal drugs.
Used in the Preparation of Ketoconazole:
trans-[2-BroMoMethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]Methyl Benzoate is used as an intermediate in the synthesis of Ketoconazole (K186000), an antifungal medication used to treat a variety of fungal infections, including those caused by yeast and other fungi.
Used in the Preparation of Itraconazole:
trans-[2-BroMoMethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]Methyl Benzoate is also used as an intermediate in the synthesis of Itraconazole (I937500), an antifungal drug used to treat a wide range of fungal infections, including aspergillosis, blastomycosis, and histoplasmosis.
Used in the Preparation of Terconazole:
Additionally, trans-[2-BroMoMethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]Methyl Benzoate is used in the preparation of Terconazole, an antifungal agent used to treat infections caused by dermatophytes, yeasts, and other fungi, particularly in the treatment of vaginal yeast infections.

Upstream product

• 2631-72-3 2,4-dichlorophenacyl bromide 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 172032-21-2 (2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol 
• 532-32-1 sodium benzoate 
• 497250-93-8 (+/-)-2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane 
• 68751-57-5 2-(2,4-dichlorophenyl)-2-bromomethyl-4-hydroxymethyl-1,3-dioxolane 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

Synthesis, antifungal activity and structure-activity relationships of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)- 1,3-dioxolanes

A series of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)-1,3-dioxolanes Ia-u was synthesized and tested in vitro against pathogenic fungi in man, animals and plants: Candida albicans, Aspergillus flavus and Fusarium solani. Compounds Iq-t with two polyazol groups have an in vitro activity against these fungi with MIC (minimum inhibitory concentration) value of 5 μg mL-1.

Stereoselective Syntheses of Both Enantiomers of Ketoconazole from (R)- and (S)-Epichlorohydrin

Stereoselective syntheses of both enantiomers of ketoconazole (1) from commercially available (R)- or (S)-epichlorohydrin has been developed.The key-step of syntheses involves the selective substitution of the methylene chlorine atom by benzoate on a mixture of (2S,4R)-14a and (2R,4R)-15a or of their enentiomers, followed by crystalization of the corresponding cis-benzoates, (2R,4R)-18 or (2S,4S)-18, from which (+)- or (-)-1 were obtained as described for (+/-)-1.The ee's of (+)- and (-)-ketocanazole were determined by HPLC on the CSP Chiracel OD-H.

Synthesis and 13C NMR Spectra of cis- and trans-methyl>>-1,3-dioxolane-4-methanols

Syntheses and 13C nmr spectra of a number of cis and trans 2-(haloaryl)-2--4-(hydroxymethyl)-1,3-dioxolanes are described.The haloaryl groups are 2,4-dichloro, 2,4-difluoro-, 4-chloro- and 4-bromophenyl.In these series, some of the cis compounds become available through crystalline bromo benzoates 5.Separations of some trans isomers are achieved through fractional crystallizations of imidazolyl benzoate nitrates 6.Stereochemical assignments are based primarily on one major 13C chemical shift difference, namely that of C-4 of the 1,3-dioxolane ring, the chemical shift of the trans isomers being 1.0-2.5 ppm downfield from that of the cis isomers.