619-60-3

Usage

Uses

Used in Chemistry Experiments:
4-(Dimethylamino)phenol is used as a pH indicator for its ability to change color from colorless to pink within the pH range of 6.8 to 8.2, making it a valuable tool in educational and research settings for visualizing changes in acidity or alkalinity.
Used in Organic Synthesis:
As a reagent, 4-(Dimethylamino)phenol is utilized in organic synthesis processes, contributing to the creation of a variety of chemical compounds and intermediates that are essential in the development of new substances and materials.
Used in Pharmaceutical Production:
4-(Dimethylamino)phenol serves as a raw material in the manufacturing of pharmaceuticals, playing a crucial role in the synthesis of certain drugs, thereby impacting the medical and healthcare industry.
Used in Dye Production:
4-(Dimethylamino)phenol is also used in the production of dyes, contributing to the coloration of various products in different industries, including textiles and plastics.
Used in Photography:
4-(Dimethylamino)phenol has potential applications in the field of photography, where it may be involved in the development of photographic films or papers, adding to the visual arts and imaging technology.
Used in Hair Dye Industry:
With its potential applications in hair dyes, 4-(Dimethylamino)phenol contributes to the cosmetic industry, providing color options for hair care products.
However, due to its potential harmful effects if ingested, inhaled, or absorbed through the skin, and its ability to cause irritation or sensitization upon contact, it is imperative to handle 4-(Dimethylamino)phenol with appropriate safety measures.

InChI:InChI=1/C8H11NO.C2H2O4/c1-9(2)7-3-5-8(10)6-4-7;3-1(4)2(5)6/h3-6,10H,1-2H3;(H,3,4)(H,5,6)

Upstream product

• 109-99-9 tetrahydrofuran 
• 60-29-7 diethyl ether 
• 591-51-5 phenyllithium 
• 874-52-2 N,N-dimethylaniline N-oxide 
• 150-75-4 N-methyl-p-aminophenol 
• 74-88-4 methyl iodide 
• 54737-34-7 4-(N,N-dimethylamino)phenoxyl radical 
• 106-50-3 1,4-phenylenediamine 
• 7295-85-4 catechin 
• 154-23-4 (+/-)-epicatechin 
• 123-30-8 4-amino-phenol 
• 50-00-0 formaldehyd 
• 13607-64-2 1-(dimethylamino)-4-(trifluoromethyl)sulfonylbenzene 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 14200-18-1 4-Dimethylamino-3-isopropyl-phenol 
• 109444-29-3 4-(2-dimethylamino-ethoxy)-N,N-dimethyl-aniline 
• 98908-55-5 Z(OMe)-Gly-ODAP 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 54737-34-7 4-(N,N-dimethylamino)phenoxyl radical 
• 123-30-8 4-amino-phenol 
• 108-46-3 recorcinol 
• 123-31-9 hydroquinone 
• 1953-54-4 indol-5-ol 
• 56-69-9 5-hydroxytryptophan 
• 120-80-9 benzene-1,2-diol 
• 56305-04-5 trolox 
• 51-61-6 dopamine 
• 138-65-8 Norepinephrine 

Relevant academic research and scientific papers

Energetics of an n → π* interaction that impacts protein structure

(Figure Presented) The trans/cis ratio of the amide bond in N-formylproline phenylesters correlates with electron withdrawal by a para substituent. The slope of the Hammett plot (ρ = 0.26) is indicative of a substantial effect. This effect arises from a favorable n → π* interaction between the amide oxygen and ester carbonyl. In a polypeptide chain, an analogous interaction can stabilize the conformation of trans peptide bonds, α-helices, and polyproline type-II helices.

Designing bimetallic zeolitic imidazolate frameworks (ZIFs) for aqueous catalysis: Co/Zn- ZIF-8 as a cyclic-durable catalyst for hydrogen peroxide oxidative decomposition of organic dyes in water

ZIF-8 is well known hybrid material that is self-assembled from inorganic and organic moieties. It has several potential applications due to its unique structure. One of these potential applications is in advanced oxidation processes (AOP) via a heterogeneous catalysis system. The use of modified ZIF-8/H2O2for the destruction of the azo dye methyl orange (MO) is presented in this work to explore its efficacy. This work presents the bimetallic Co/Zn-ZIF-8 as an efficient catalyst to promote H2O2oxidation of the MO dye. Co/Zn-ZIF-8 was synthesized through a hydrothermal process, and the pristine structure was confirmed using XRD, FTIR, and XPS. The Co/Zn-ZIF-8/H2O2system successfully decolorized MO at the selected pH 6.5. It was found that more than 90% of MO (10 ppm) was degraded within only about 50 minutes. Proposed radical and redox mechanisms are presented for H2O2decomposition where the redox mechanism is suggested to predominate via a Co(II)/Co(III) redox consecutive cyclic process.

Synthesis method of substituted phenol

The invention provides a synthesis method of substituted phenol. The target product substituted phenol is prepared by taking substituted benzene as an initial raw material, and the whole synthetic process is high in selectivity, high in yield, convenient to operate and high in atom economy.

Optimizing the crystallization process of conjugated polymer photocatalysts to promote electron transfer and molecular oxygen activation

Photocatalytic reactive oxygen species (ROS)-induced reactions provide an appealing method to solve the environmental and energy issues, whereas the current oxidation reaction generally suffered from low efficiency and poor selectivity due to uncontrollable O2 activation process. In view of the existence of competitive electron and energy transfer pathway, we propose that highly efficient superoxide radical anion (·O2?) generation can be achieved by optimizing the order degree of the photocatalyst. Herein, by taking carbon nitride polymer as an example, we optimized the crystallization process of carbon nitride polymer by selecting precursors of different polymerization degrees with a molten salt method. Benefiting from the high crystallinity, extended π-conjugated system and strong van der-Waals interactions between interlayers, the modified carbon nitride polymer exhibited accelerated charge transport and enhancement in electron induced molecular oxygen activation reactions under visible light. Consequently, the CCN-P exhibits about 1.5 times higher conversion rate in hydroxylation of phenylboronic acid and over 6-fold faster degradation rate in Rh B organic pollutants photodegradation with respect to pristine carbon nitride. This study provides an in-depth understanding on the optimization of the O2 activation process and the design of advanced photocatalysts.

Heterogeneous Palladium–Chitosan–CNT Core–Shell Nanohybrid Composite for Ipso-hydroxylation of Arylboronic Acids

Abstract: A novel palladium-nanohybrid (Pd–Chitosan–CNT) catalytic composite has been developed using CNT–chitosan nanocomposite and palladium nitrate. The prepared catalytic platform displays excellent catalytic reactivity for the ipso-hydroxylation of various arylboronic acids with a mild oxidant aqueous H2O2 at room temperature, affording the corresponding phenols in excellent yields. Significantly, the easy recovery and reusability by simple manipulation demonstrate the green credentials of this catalytic platform. Graphical Abstract: [Figure not available: see fulltext.]

Synergistic catalysis of Cu+/Cu0 for efficient and selective N-methylation of nitroarenes with para-formaldehyde

In this paper, an inexpensive heterogeneous copper nanoparticles catalyst derived from CuAl-layered double hydroxide via an in situ topotactic transformation process was developed. Cu nanoparticles with uniform size were homogeneously dispersed on amorphous Al2O3 with strong metal-support interaction. Characterization results reveals that the Cu0 and Cu+ were simultaneously formed with Cu+ species as the dominant sites on the surface during the reduction process. The resultant catalyst Cu/Al2O3 demonstrates high catalytic activity, selectivity and durability for the reductive N-methylation of easily available nitroarenes in a cost-efficient, environmentally friendly and cascade manner. A broad spectrum of nitroarenes could be efficiently N-methylated to their corresponding N,N-dimethyl amines with good compatibility of various functional groups. The protocol is also applicable for the late-stage functionalization of biologically and pharmaceutically active nitro molecules. A structure-function relationship discloses that Cu0 and Cu+ sites on the surface pronouncedly boosts the reaction efficiency in a synergistic manner, in which Cu0 could facilitate H2 production and N-methylation of anilines, while Cu+ is considerably more active and participates in the overall process of the selective N-methylation of nitroarenes. Moreover, the catalyst also showed a strong stability and could be easily separated for successive reuses without an appreciable loss in activity and selectivity.

Method for N-methylation reaction of nitro-compound

The invention discloses a method for direct N-methylation reaction by taking a nitro-compound as a raw material. The method adopts a Cu-based catalyst and polyformaldehyde and can realize the direct N-methylation reaction of the nitro-compound under mild conditions.

Cyanide antidote synthesis method

The invention relates to a cyanide antidote synthesis method, which comprises: adding a formaldehyde solution and p-nitroanisole in an ethanol solution, adjusting the pH value to 4 with hydrochloric acid, heating, slowly adding iron powder, carrying out a reaction after the adding to obtain 4-dimethylaminoanisole, adding the 4-dimethylaminoanisole to toluene, adding aluminum trichloride, carryingout heating reflux, removing the methyl, cooling, adding a saturated sodium bicarbonate solution, filtering out the solid while hot, separating the liquid, carrying out water washing on the toluene phase, separating the liquid, carrying out pressure reducing evaporation to remove the toluene, and carrying out heating evaporation to obtain the product. According to the present invention, the product obtained through the curing has the purity of more than 99% and the yield of more than 80%; and the method has advantages of cheap and easily-available raw materials, no dangerous operation, less wastewater generation, low environmental pollution and high overall yield, and is suitable for large-scale production.

POLYMERIC AMINE SYNERGIST

A polymeric amine synergist is disclosed herein. An example of the polymeric amine synergist includes an aniline moiety, a polyethylene glycol chain, and an ether linkage attaching one end of the polyethylene glycol chain to the aniline moiety. The polymeric amine synergist may be included in a photo curable ink composition.

Transformation of N, N-Dimethylaniline N-Oxides into Diverse Tetrahydroquinoline Scaffolds via Formal Povarov Reactions

A one-pot protocol for the assembly of diversely functionalized tetrahydro-, hexahydrofuro-, hexahydropyrano-, and tetrahydrobenzofuroquinolines from N,N-dimethylaniline N-oxides and various electron-rich olefins in a tandem Polonovski-Povarov sequence is reported. Following activation of the N-O bond with Boc2O, an exocyclic iminium ion is unveiled upon exposure to tin(IV) chloride. A formal inverse-electron-demand aza-Diels-Alder cyclization generates the tetrahydroquinoline core of 29 examples in up to 92% yield.