619-60-3

Basic information

• Product Name: 4-(dimethylamino)phenol
• Synonyms: 4-(dimethylamino)phenol;4-N,N-DIMETHYLAMINOPHENOL;N,N-Dimethyl-4-aminophenol;N,N-Dimethyl-p-hydroxyaniline;p-(Dimethylamino)phenol;p-Hydroxy-N,N-dimethylaniline;Phenol,4-(diMethylaMino)-;Phenol, p-(dimethylamino)-
• CAS NO: 619-60-3
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• EINECS: 210-604-8
• Mol File: 619-60-3.mol
• Article Data: 48

Chemical Properties

• Melting Point: 138-141℃
• Boiling Point: 260℃
• Flash Point: 136℃
• Appearance: /
• Density: 1.089
• Vapor Pressure: 0.00789mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 10.11±0.13(Predicted)
• CAS DataBase Reference: 4-(dimethylamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dimethylamino)phenol(619-60-3)
• EPA Substance Registry System: 4-(dimethylamino)phenol(619-60-3)

Safety Data

• Hazardous Substances Data: 619-60-3(Hazardous Substances Data)

Usage

Description

4-(Dimethylamino)phenol, with the chemical formula C8H11NO, is a white crystalline solid that possesses a molecular weight of 137.18 g/mol. This versatile chemical compound is known for its applications across various fields due to its unique properties.

Uses

Used in Chemistry Experiments:
4-(Dimethylamino)phenol is used as a pH indicator for its ability to change color from colorless to pink within the pH range of 6.8 to 8.2, making it a valuable tool in educational and research settings for visualizing changes in acidity or alkalinity.
Used in Organic Synthesis:
As a reagent, 4-(Dimethylamino)phenol is utilized in organic synthesis processes, contributing to the creation of a variety of chemical compounds and intermediates that are essential in the development of new substances and materials.
Used in Pharmaceutical Production:
4-(Dimethylamino)phenol serves as a raw material in the manufacturing of pharmaceuticals, playing a crucial role in the synthesis of certain drugs, thereby impacting the medical and healthcare industry.
Used in Dye Production:
4-(Dimethylamino)phenol is also used in the production of dyes, contributing to the coloration of various products in different industries, including textiles and plastics.
Used in Photography:
4-(Dimethylamino)phenol has potential applications in the field of photography, where it may be involved in the development of photographic films or papers, adding to the visual arts and imaging technology.
Used in Hair Dye Industry:
With its potential applications in hair dyes, 4-(Dimethylamino)phenol contributes to the cosmetic industry, providing color options for hair care products.
However, due to its potential harmful effects if ingested, inhaled, or absorbed through the skin, and its ability to cause irritation or sensitization upon contact, it is imperative to handle 4-(Dimethylamino)phenol with appropriate safety measures.

InChI:InChI=1/C8H11NO.C2H2O4/c1-9(2)7-3-5-8(10)6-4-7;3-1(4)2(5)6/h3-6,10H,1-2H3;(H,3,4)(H,5,6)

Upstream product

• 5567-02-2 4-hydroxyphenyltrimethylammonium chloride 
• 1953-54-4 indol-5-ol 
• 54737-34-7 4-(N,N-dimethylamino)phenoxyl radical 
• 123-30-8 4-amino-phenol 
• 7664-93-9 sulfuric acid 
• 100-04-9 p-dimethylaminobenzenediazonium chloride 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 
• 547-58-0 methyl orange 
• 67-56-1 methanol 
• 540-38-5 p-Iodophenol 
• 124-40-3 dimethyl amine 
• 1463426-91-6 4-(dimethylamino)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 50-00-0 formaldehyd 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 110608-33-8 Acrylic acid 4-dimethylamino-phenyl ester 
• 783-12-0 4-Dimethylamino-1-(1,1,2-trifluor-2-chlor-aethoxy)-benzol 
• 98-94-2 N,N-dimethyl-cyclohexanamine 
• 103023-50-3 4-(dimethylamino)cyclohexanol 
• 91430-31-8 C₁₁H₁₆N₂O₂ 
• 1265828-89-4 5-(4-(N,N-dimethylamino)phenoxy)acenaphthenequinone 
• 1463426-91-6 4-(dimethylamino)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 51601-26-4 N,N-dimethyl-4-(2-propen-1-yl)benzenamine 
• 13607-64-2 1-(dimethylamino)-4-(trifluoromethyl)sulfonylbenzene 
• 69446-62-4 4-(4-methoxyphenoxy)-N,N-dimethylaniline 
• 35065-66-8 p-(2,4,6-Trinitrophenoxy)-N,N-dimethylanilin 
• 54737-34-7 4-(N,N-dimethylamino)phenoxyl radical 

Relevant articles and documents

Energetics of an n → π* interaction that impacts protein structure

(Figure Presented) The trans/cis ratio of the amide bond in N-formylproline phenylesters correlates with electron withdrawal by a para substituent. The slope of the Hammett plot (ρ = 0.26) is indicative of a substantial effect. This effect arises from a favorable n → π* interaction between the amide oxygen and ester carbonyl. In a polypeptide chain, an analogous interaction can stabilize the conformation of trans peptide bonds, α-helices, and polyproline type-II helices.

Synthesis method of substituted phenol

The invention provides a synthesis method of substituted phenol. The target product substituted phenol is prepared by taking substituted benzene as an initial raw material, and the whole synthetic process is high in selectivity, high in yield, convenient to operate and high in atom economy.

Heterogeneous Palladium–Chitosan–CNT Core–Shell Nanohybrid Composite for Ipso-hydroxylation of Arylboronic Acids

Abstract: A novel palladium-nanohybrid (Pd–Chitosan–CNT) catalytic composite has been developed using CNT–chitosan nanocomposite and palladium nitrate. The prepared catalytic platform displays excellent catalytic reactivity for the ipso-hydroxylation of various arylboronic acids with a mild oxidant aqueous H2O2 at room temperature, affording the corresponding phenols in excellent yields. Significantly, the easy recovery and reusability by simple manipulation demonstrate the green credentials of this catalytic platform. Graphical Abstract: [Figure not available: see fulltext.]