6303-18-0

Usage

Uses

Used in Pharmaceutical Industry:
Pentane-1-sulfonyl chloride is used as a reagent in the synthesis of various pharmaceuticals for its ability to react with a wide range of functional groups, contributing to the development of new drugs and improving the efficiency of existing ones.
Used in Agrochemical Industry:
In the agrochemical industry, pentane-1-sulfonyl chloride is used as a reagent in the production of agrochemicals, aiding in the development of effective pesticides and other agricultural chemicals.
Used in Synthesis of Sulfamethizole:
Pentane-1-sulfonyl chloride is used as a key intermediate in the synthesis of sulfamethizole, a sulfonamide antibiotic, for its role in facilitating the formation of the desired product.
Used as a Chlorinating Agent:
Pentane-1-sulfonyl chloride is used as a chlorinating agent in laboratory and industrial settings, enabling the introduction of chlorine atoms into various organic compounds for a range of applications.
Used in Organic Synthesis:
In organic synthesis, pentane-1-sulfonyl chloride is used as a versatile reagent for its ability to react with multiple functional groups, allowing for the creation of diverse organic compounds for various purposes.

InChI:InChI=1/C5H11ClO2S/c1-2-3-4-5-9(6,7)8/h2-5H2,1H3

Upstream product

• 110-53-2 1-Bromopentane 
• 17356-08-0 thiourea 
• 22767-49-3 sodium pentane-1-sulfonate 
• 7647-01-0 hydrogenchloride 
• 50-00-0 formaldehyd 
• 110-66-7 n-pentanethiol 
• 64-19-7 acetic acid 
• 7732-18-5 water 
• 7782-50-5 chlorine 
• 35452-30-3 1-pentanesulfonic acid 
• 32446-40-5 n-pentyl thiocyanate 
• 112-51-6 diamyl disulfide 

Downstream Products

• 59427-10-0 Pentane-1-sulfonic acid 4-(1,1,3,3-tetramethyl-butyl)-phenyl ester 
• 22535-81-5 Pentyl-sulfonsaeure-⁽¹⁾-phenylester 
• 22767-49-3 sodium pentane-1-sulfonate 
• 1162128-96-2 N-(4-acetylphenyl)pentane-1-sulfonamide 
• 2697-53-2 methyl 1-pentanesulfonate 
• 926298-85-3 N-(3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl)-pentane-1-sulfonamide 
• 375-81-5 perfluoro-n-pentane sulfonylfluoride 
• 406205-75-2 3-(3-Methyl-2-nitro-phenoxy)phenyl n-pentanesulphonate 
• 96309-85-2 Trianilinophosphazosulfonylpentyl 
• 101122-20-7 N--pentan-sulfonimidsaeure-(1)-<4-nitro-phenylester> 
• 95438-30-5 Tris-<4-nitro-phenoxy>-phosphazosulfonylpentyl 
• 80259-04-7 N-(4-aminophenyl)sulfamoylpentane 
• 88412-81-1 Pentane-1-sulfonic acid [4-(acridin-9-ylamino)-3-methylamino-phenyl]-amide 
• 220584-79-2 (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-methoxy-phenyl)-1-{2-[(pentane-1-sulfonyl)-propyl-amino]-ethyl}-pyrrolidine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)

The mitogen-activated protein kinase (MAP) kinase 4 (MKK4) was found to be a major regulator of liver regeneration and could be a valuable drug target addressing liver related diseases by restoring its intrinsic regenerative capacity. We report on the synthesis and optimization of novel MKK4 inhibitors following a target-hopping strategy from the FDA-approved BRAFV600E inhibitor PLX4032 (8). Applying an iterative multi-parameter optimization process we carved out essential structural features yielding in compounds with a low nanomolar affinity for MKK4 and excellent selectivity profiles against the main off-targets MKK7 and JNK1, which, upon relevant inhibition, would totally abrogate the pro-regenerative effect of MKK4 inhibition, as well as against the off-targets MAP4K5, ZAK and BRAF with selectivity factors ranging from 40 to 430 for our best-balanced compounds 70 and 73.

N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing

A series of 11 N-sulfonyl homoserine lactones has been synthesised. Some of them were found to competitively inhibit the action of 3-oxohexanoyl-L- homoserine lactone, the natural inducer of bioluminescence in the bacterium Vibrio fischeri. Molecular modeling suggests a possible explanation based on the prevention of structural rearrangements necessary for the formation of the active dimer of LuxR.

A new, mild preparation of sulfonyl chlorides

A new method was developed for the preparation of sulfonyl chlorides from sulfonic acids under neutral conditions using 2,4,6-trichloro-1,3,5-triazine as chlorinating agent.

COMPOUNDS AND METHODS FOR CONTROLLING BACTERIAL VIRULENCE

Novel sulfonated homoserine lactones formula I have been found to act ac quorum sensing inhibitors. As such, they may be useful in the treatment of bacterial infections.

Endothelin antagonists

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

N-sulfonyl-N-dihalophenylimidazolidinediones

3-(3' -Dihalophenyl)-1-sulfonylimidazolidine-2,4-5'-diones of the formula: STR1 wherein X is a halogen atom, R1 is a C1 -C12 alkyl group, a C2 -C4 alkenyl group or a halogenated C1 -C4 alkyl group having 1 to 3 halogen atoms, and R2 and R3 are individually a hydrogen atom or a methyl group, which show high microbicidal activities against various fungi and bacteria without any material toxicity to mammals and which plants and can be produced by reacting the corresponding 1-unsubstituted compound with a sulfonyl halide.