63218-14-4

Basic information

• Product Name: 2-(4-NITROPHENOXY)ACETAMIDE
• Synonyms: TIMTEC-BB SBB000350;2-(4-NITROPHENOXY)ACETAMIDE;(4-Nitrophenoxy)acetamide
• CAS NO: 63218-14-4
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• Mol File: 63218-14-4.mol

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 463.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.375±0.06 g/cm3(Predicted)
• PKA: 14.71±0.40(Predicted)
• CAS DataBase Reference: 2-(4-NITROPHENOXY)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-NITROPHENOXY)ACETAMIDE(63218-14-4)
• EPA Substance Registry System: 2-(4-NITROPHENOXY)ACETAMIDE(63218-14-4)

Safety Data

• Hazardous Substances Data: 63218-14-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-(4-NITROPHENOXY)ACETAMIDE is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products. Its chemical properties make it a valuable component in the creation of these compounds.
Used in Anti-Inflammatory Applications:
2-(4-NITROPHENOXY)ACETAMIDE has been studied for its potential as an anti-inflammatory agent, suggesting that it could be used in the treatment of inflammation-related conditions. Its ability to modulate inflammatory responses could offer therapeutic benefits in this area.
Used in Cancer Therapy Research:
2-(4-NITROPHENOXY)ACETAMIDE has also been investigated for its potential to inhibit the growth of cancer cells, indicating a possible role in cancer therapy. The exploration of its effects on cancer cell proliferation and survival could lead to advancements in oncological treatments.
Used in Dye and Pigment Production:
2-(4-NITROPHENOXY)ACETAMIDE is employed in the production of dyes and pigments due to its reactivity with other chemicals, which results in the creation of vibrant colors. Its application in this industry highlights its potential for use in a wide range of color-related products.

Upstream product

• 1124-31-8 potassium 4-nitrophenolate 
• 79-07-2 Chloroacetamide 
• 824-78-2 4-nitrophenol sodium salt 
• 100-02-7 4-nitro-phenol 
• 144-48-9 iodacetamide 
• 683-57-8 bromo-acetic acid amide 
• 33901-46-1 2-(4-nitrophenoxy)acetonitrile 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 1798-11-4 4-nitrophenoxyacetic acid 

Downstream Products

• 6033-85-8 (4-acetylamino-phenoxy)-acetic acid amide 
• 62100-58-7 Gca-pNA 
• 58232-55-6 4-(carbamoylmethoxy)aniline 
• 575473-01-7 N₄-(4-aminocarbonylmethyloxyphenyl)-2-chloro-5-fluoro-4-pyrimidineamine 
• 575473-00-6 2-chloro-N₄-(4-(cyanomethyloxy)phenyl)-5-fluoro-4-pyrimidineamine 

Relevant articles and documents

2,4-Pyrimidinediamine Compounds and Their Uses

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide

A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.

COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY

The invention encompasses compounds having formula (I-V) and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Phosphorylamides, their preparation and use

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.

Condensed 4-aminopyridines with antirheumatic activity

Compounds of formula I STR1 and pharmaceutically acceptable salts thereof in which one of A or B represents N and the other represents N or C--R3 ; R1 represents hydrogen, halo, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy, alkoxycarbonyl, alkanoylamino or carbamoylalkenyl; R2 represents hydrogen, alkyl, halo, alkoxy, hydroxy, alkanoyloxy, or phenoxy; R3 represents hydrogen or alkyl; R4 represents hydrogen, halo, alkoxycarbonyl, cyano, benzyloxycarbonyl, alkanoyl, benzoyl, alkyl, carboxy, alkylthio or carbamoyl; R5 represents hydrogen or alkyl; R9 represents hydrogen or alkyl; R10 represents phenyl, pyridyl or pyrimidinyl substituted by OR6 and optionally further substituted wherein R6 represents hydrogen, alkyl, alkoxycarbonyl or carbamoyl, alicyclic hydrocarbon, phenyl, cycloalkylalkyl, arylalkyl or pyridyl; or when R10 represents phenyl, OR6 represents a monosaccharide group or a disaccharide group; which are antirheumatic agents. Compositions containing these compounds and processes to prepare them are also disclosed.