6337-41-3

Basic information

• Product Name: 4-hydroxy-4-pyridin-2-yl-butan-2-one
• Synonyms: 2-butanone, 4-hydroxy-4-(2-pyridinyl)-; 4-Hydroxy-4-(pyridin-2-yl)butan-2-one
• CAS NO: 6337-41-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 6337-41-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 300.1°Cat760mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 0.000511mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 4-hydroxy-4-pyridin-2-yl-butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-4-pyridin-2-yl-butan-2-one(6337-41-3)
• EPA Substance Registry System: 4-hydroxy-4-pyridin-2-yl-butan-2-one(6337-41-3)

Safety Data

• Hazardous Substances Data: 6337-41-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-7(11)6-9(12)8-4-2-3-5-10-8/h2-5,9,12H,6H2,1H3

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 56-23-5 tetrachloromethane 
• 7732-18-5 water 
• 67-64-1 acetone 
• 108-22-5 Isopropenyl acetate 
• 14035-54-2 1,1-diphenyl-1-hydroxy-3-butanone 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 105902-82-7 2-(hydroxy-[2]pyridyl-methyl)-acetoacetic acid ethyl ester 
• 40614-52-6 1-pyridin-2-yl-butane-1,3-dione 

Downstream Products

• 98-98-6 2-Picolinic acid 

Relevant articles and documents

L-proline-catalyzed asymmetric direct aldol reaction of heteroaromatic aldehydes and acetone: Improvement of catalytic efficiency in ionic liquid bmim [BF4]

L-proline in bmim [BF4] ionic liquid has been successfully used as an efficient and reusable catalyst for the direct asymmetric aldol reaction of acetone with different heteroaromatic aldehydes to afford higher selectivity of the aldol products with good enantioselectivity. Copyright Taylor & Francis Group, LLC.

Tandem catalysis by lipase in a vinyl acetate-mediated cross-aldol reaction

The lipase Novozym435 (0.6% w/w) was used in tandem with organocatalysts in a first vinyl/isopropenyl acetate-mediated aldol reaction. The reaction was facilitated through the lipase-catalyzed in situ generation of acetaldehyde/acetone. The important features of the present methodology include the mild and facile reaction conditions, regenerability of the lipase, comparatively high yields and minimal side product formation.

Chitosan hydrogel: A green and recyclable biopolymer catalyst for aldol and Knoevenagel reactions

Chitosan hydrogel is efficiently utilized as an organocatalyst for aldol and Knoevenagel reactions, providing the products in high yields with a high chemoselectivity under biphasic conditions. The catalyst was recovered by simple filtration and reused several times without significant loss of activity. the Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2006.