6481-73-8

Basic information

• Product Name: 4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester
• Synonyms: (4-Methylphenylsulfinyl)(4-methylphenyl) sulfide;4-Methylbenzenesulfinothioic acid S-(4-methylphenyl) ester;4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester;p-Tolyl(p-tolylsulfinyl) sulfide
• CAS NO: 6481-73-8
• Molecular Formula: C₁₄H₁₄OS₂
• Molecular Weight: 262.39
• Mol File: 6481-73-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 430.9°C at 760 mmHg
• Flash Point: 214.4°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 3.15E-07mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester(6481-73-8)
• EPA Substance Registry System: 4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester(6481-73-8)

Safety Data

• Hazardous Substances Data: 6481-73-8(Hazardous Substances Data)

Usage

General Description

4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester is a chemical compound with a molecular formula of C9H10OS2. It is a thiosulfinic acid ester that is used in the synthesis of organic compounds and as a reagent in chemical reactions. It is a white crystalline solid with a melting point of 103-105°C and a boiling point of 285.9°C at 760 mmHg. 4-Methylbenzenethiosulfinic acid S-(4-methylphenyl) ester has potential applications in the pharmaceutical and agricultural industries for the development of new drugs and pesticides. However, it is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C14H14OS2/c1-11-3-7-13(8-4-11)16-17(15)14-9-5-12(2)6-10-14/h3-10H,1-2H3

Upstream product

• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 106-45-6 para-thiocresol 
• 536-57-2 p-toluene sulfinic acid 
• 108-03-2 1-Nitropropane 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 67-56-1 methanol 
• 842120-80-3 (±)-N-(naphthalen-2-ylmethylene)-p-toluenesulfinamide 
• 813461-58-4 C₁₁H₁₃NOS 
• 103-19-5 di(p-tolyl) disulfide 
• 7205-74-5 1-methoxy-4-(2-methyl-propane-2-sulfinyl)-benzene 
• 78-79-5 isoprene 
• 623-13-2 4-methylphenyl methylsulfide 
• 24824-93-9 chloromethyl p-tolyl sulfoxide 
• 210486-94-5 (2S,3R)-1-Bromo-2-fluoromethyl-3-((R)-toluene-4-sulfinyl)-butan-2-ol 

Downstream Products

• 103-19-5 di(p-tolyl) disulfide 
• 14370-67-3 p-tolyl disulfoxide 
• 672-78-6 methyl p-toluene sulfinate 
• 139705-19-4 ((C₆H₅)3P)2Pt₂(SC₆H₄CH₃)2(S(O)C₆H₄CH₃)2 
• 78135-09-8 bis(p-tolylthio)acetonitrile 
• 35469-22-8 p-toluenesulphonic acid S-benzylisothiouronium salt 
• 121955-59-7 toluene-4-thiosulfinic acid S-(4-chloro-phenyl ester) 
• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 29627-34-7 4-(phenyldisulfanyl)toluene 
• 882-33-7 diphenyldisulfane 
• 20333-41-9 bis(3-methylphenyl)disulfide 
• 98147-48-9 2-isopropyl-5-methylcyclohexyl 4-methylbenzenesulfinate 
• 16066-33-4 4-<(4-methylphenyl)sulfinyl>morpholine 
• 17041-81-5 p-tolyl benzenethiosulfonate 

Relevant articles and documents

Isocyanide-Induced Esterification of Sulfinic Acids to Access Sulfinates

The isocyanide-induced esterification of sulfinic acids with alcohols or thiophenols access to sulfinates has been developed. Various primary, secondary, and tertiary alcohols could be compatible with the established protocols. Notably, such an isocyanide-induced synthetic strategy presented the advantages of simple operation, good functional group tolerance, and more than 40 examples up to 99% yields. (Figure presented.).

Straightforward and Sustainable Synthesis of Sulfonamides in Water under Mild Conditions

Ideally, a sustainable chemical synthesis should involve the use of non-toxic solvents and reactants, easy separations and purification by energy-efficient processes. In this context, reconsidering the synthesis of widely used drugs is especially timely and should allow important benefits to be obtained in terms of environmental impact. Sulfonamides are pertinent as their synthesis generally requires the use of toxic and/or hard-to-remove solvents such as dichloromethane, DMF and DMSO. In addition, toxic and highly reactive sulfur-containing sources such as sulfonyl chloride are often involved and coupled with amines. Moreover, the latter may exhibit some toxicity and are generally difficult to purify. Herein, we disclose the unprecedented and sustainable synthesis of sulfonamides by using sodium sulfinate as a commercial and stable sulfur source and nitroarenes as the nitrogen-containing reactant. In addition, under the optimized conditions only water is used as a “green” solvent and the products are collected by simple filtration.

Redox Active Sodium Iodide/Recyclable Heterogeneous Solid Acid: An Efficient Dual Catalytic System for Electrochemically Oxidative α-C?H Thiocyanation and Sulfenylation of Ketones

An efficient electrochemically oxidative α-C?H thiocyanation and sulfenylation of ketones has been developed in a simple undivided cell under constant current condition.?The electrochemistry performs using NaI as the redox catalyst and heterogeneous solid salt Amberlyst-15(H) (A-15(H)) as proton catalyst?without the addition of external conductive salts. The protocol proved to be practical since the solid salt could be reused in up to five consecutive gram-scale runs without significant decrease in efficiency. Control experiments and cyclic voltammetry analysis disclose that the reaction proceeds likely via a cascade α-halogenation and subsequent thiocyanation or sulfenylation. (Figure presented.).