65080-41-3Relevant academic research and scientific papers
Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of γ-ketonitriles through nitrile alkylation of enol acetates
Cheng, Pi,Wang, Wei,Wang, Lin,Zeng, Jianguo,Reiser, Oliver,Liang, Yun
, p. 1408 - 1412 (2019/05/06)
Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare γ-ketonitriles through the direct C(sp3)-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source.
I2/TBHP-mediated oxidative coupling of ketones and toluene derivatives: a facile method for the preparation of α-benzoyloxy ketones
Chen, Cui,Liu, Weibing,Zhou, Peng,Liu, Hailing
, p. 20394 - 20397 (2017/04/19)
An efficient oxidative approach was developed for the α-benzoyloxylation of ketones using tert-butyl hydroperoxide (TBHP). This process provided facile access to a wide range of α-benzoyloxy ketones in good to excellent yields via the direct oxidative α-benzoyloxylation of a structurally diverse series of ketones using simple arylmethane compounds.
NBu4NI-catalyzed α-benzoxylation of ketones with terminal aryl alkenes
Mondal, Buddhadeb,Sahoo, Subas Chandra,Pan, Subhas Chandra
, p. 3135 - 3140 (2015/05/13)
A metal-free protocol for the α-benzoxylation of ketones has been developed by using terminal aryl alkenes as an arylcarboxy surrogate. Moderate to good yields were attained for a variety of propiophenones and acetophenones by using tetra-n-butylammonium iodide (TBAI) as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant under ambient reaction conditions. An efficient synthesis for the α-benzoxylation of aryl ketones has been developed by using terminal aryl alkenes as the arylcarboxy surrogate. The products were obtained in moderate to good yields for a broad scope of substrates. Tetra-n-butylammonium iodide (TBAI) and tert-butyl hydroperoxide (TBHP) were employed as the catalyst and oxidant, respectively.
I2-catalyzed regioselective oxo- and hydroxy-acyloxylation of alkenes and enol ethers: A facile access to α-acyloxyketones, esters, and diol derivatives
Reddi, Rambabu N.,Prasad, Pragati K.,Sudalai, Arumugam
supporting information, p. 5674 - 5677 (2015/02/19)
I2-catalyzed oxo-acyloxylation of alkenes and enol ethers with carboxylic acids providing for the high yield synthesis of α-acyloxyketones and esters is described. This unprecedented regioselective oxidative process employs TBHP and Et3/s
A rapid and facile esterification of na-carboxylates with alkyl halides promoted by the synergy of the combined use of DMSO and an ionic liquid under ambient conditions
Dighe, Satish N.,Bhattad, Ravindra V.,Kulkarni, Raghunath R.,Jain, Kishor S.,Srinivasan, Kumar V.
experimental part, p. 3522 - 3527 (2011/02/22)
The synergy of the combined use of DMSO and an ionic liquid viz. (bbim) has brought about a rapid and efficient esterification of sodium carboxylates with acyl and alkyl halides under ambient conditions in excellent isolated yields (90-95%) in short reaction times (12-40min). Copyright Taylor & Francis Group, LLC.
Organic reactions in water: Synthesis of phenacyl esters from phenacyl bromide and potassium salts of aromatic acids in the presence of β-cyclodextrin
Narender,Somi Reddy,Pavan Kumar,Rama Rao
, p. 1681 - 1686 (2007/10/03)
A convenient and facile synthesis of phenacyl esters is reported by the reaction of phenacyl bromide with potassium salts of aromatic acids in the presence of β-cyclodextrin in water under neutral conditions. Copyright Taylor & Francis, Inc.
Kinetics of the Reactions of Phenacyl Bromide and of para-Substituted Phenacyl Bromides with Benzoate and Substituted trans-Cinnamate Ions
Srinavasan, Chockalingam,Shunmugasundaram, Arunachalam,Arumugam, Natesan
, p. 17 - 20 (2007/10/02)
The second-order rate constants for the reactions of various para-substituted phenacyl bromides with benzoate ion and with several substituted trans-cinnamate ions have been measured in 90 percent acetone - 10 percent water (v/v) mixture.Electron-releasin
Separation of Polar and Steric Effects in Reactions of ortho-Substituted Benzoate Ions with para-Substituted Phenacyl Bromides
Srinivasan, C.,Shunmugasundaram, A.,Roja, M.,Arumugam, N.
, p. 555 - 557 (2007/10/02)
The second order rate constants for SN2 reactions of several ortho-substituted benzoate ions with several para-substituted phenacyl bromides have been measured in 90percent acetone - 10percent water (v/v) mixture at 35 deg C.Satisfactory correl
