65143-37-5

Basic information

• Product Name: 2-(4-Methylphenyl)-2-oxoethyl acetate
• Synonyms: 2-(4-Methylphenyl)-2-oxoethyl acetate
• CAS NO: 65143-37-5
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21118
• Mol File: 65143-37-5.mol
• Article Data: 28

Chemical Properties

• Melting Point: 86-88°
• Boiling Point: 295.2°C at 760 mmHg
• Flash Point: 127.9°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.00155mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 2-(4-Methylphenyl)-2-oxoethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylphenyl)-2-oxoethyl acetate(65143-37-5)
• EPA Substance Registry System: 2-(4-Methylphenyl)-2-oxoethyl acetate(65143-37-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65143-37-5(Hazardous Substances Data)

Usage

General Description

2-(4-Methylphenyl)-2-oxoethyl acetate is a chemical compound with the molecular formula C11H12O3. It is an ester, specifically an acetoxyketone, and is commonly used in the production of fragrances and flavorings. 2-(4-Methylphenyl)-2-oxoethyl acetate has a fruity, sweet aroma and is often used in the formulation of perfumes and cosmetic products. It is also used as a flavoring agent in food products and beverages. 2-(4-Methylphenyl)-2-oxoethyl acetate is a colorless liquid with a pleasant fragrance, and it is considered to be safe for use in various consumer products when used in accordance with regulatory guidelines.

InChI:InChI=1/C11H12O3/c1-8-3-5-10(6-4-8)11(13)7-14-9(2)12/h3-6H,7H2,1-2H3

Upstream product

• 127-08-2 potassium acetate 
• 4209-24-9 p-methylphenacyl chloride 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 720-94-5 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 619-41-0 4-(bromoacetyl)toluene 
• 122-00-9 para-methylacetophenone 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 177750-08-2 1-(4-methylphenyl)ethenylacetamide 
• 75-75-2 methanesulfonic acid 
• 624-31-7 4-tolyl iodide 
• 13831-31-7 Acetoxyacetyl chloride 

Downstream Products

• 670-91-7 4⁽⁵⁾-(4-tolyl)-1H-imidazole 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 79-20-9 acetic acid methyl ester 
• 115-10-6 Dimethyl ether 
• 17264-54-9 sodium p-methylbenzoate 
• 22532-47-4 4-methylphenethyl acetate 
• 13603-62-8 1-(4-methylphenyl)-1,2-ethanediol 
• 1376770-94-3 4-hydroxy-4-phenyl-1-(p-tolyl)butan-1-one 
• 1629234-06-5 3-acetoxy-6-bromo-2-(4-methylphenyl)quinoline-4-carboxylic acid 
• 122262-57-1 3-hydroxy-6-methyl-2-(4-methylphenyl)quinoline-4-carboxylic acid 
• 1629233-96-0 6-bromo-3-hydroxy-2-(4-methylphenyl)quinoline-4-carboxylic acid 
• 122-00-9 para-methylacetophenone 
• 156817-47-9 (Z)-2-(p-methylphenyl)-2-buten-1-ol 
• 647026-51-5 (S)-2-methylcarbonyloxy-1-(4-methylphenyl)ethyl acetate 

Relevant articles and documents

Decarboxylative Oxyacyloxylation of Propiolic Acids: Construction of Alkynyl-Containing α-Acyloxy Ketones

Novel decarboxylative oxyacyloxylation of propiolic acids has been developed. This reaction provides an efficient access to alkynyl-containing α-acyloxy ketones from readily available starting materials and exhibits significant functional group tolerance. Furthermore, oxyacyloxylation of terminal alkynes and aliphatic propiolic acids was also developed. A possible reaction mechanism is proposed based on mechanistic studies.

Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide

A novel and efficient approach has been developed to synthesize α-sulfonylamino ketones through the reaction between terminal alkynes and sulfonamides under ambient air using PIDA (diacetoxy iodobenzene). A library of α-sulfonylamino ketone derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room temperature reaction conditions under ambient air and is operationally simple. A gram-scale synthesis demonstrates the potential applications of the present method. In addition, we have also synthesized α-acetoxy ketones in the case of absence of sulfonamide.

Oxidative α-Acetoxylation of a β-Oxime Ester with (Diacetoxyiodo)benzene Catalyzed by ScIII Salts: An Approach to the Docetaxel Side Chain

Hypervalent iodine(III) compounds have emerged as reagents of choice for α-oxidation of various ketones under mild reaction conditions. We report herein a simple method for α-hydroxylation of a β-oxime ester, which involves an oxidative α-acetoxylation us