65246-99-3

Basic information

• Product Name: (2-amino-5-bromophenyl)(4-chlorophenyl)methanone
• Synonyms: (2-aMino-5-broMophenyl)(4-chlorophenyl)Methanone
• CAS NO: 65246-99-3
• Molecular Formula: C₁₃H₉BrClNO
• Molecular Weight: 310.5737
• Mol File: 65246-99-3.mol

Chemical Properties

• Boiling Point: 458.7°C at 760 mmHg
• Flash Point: 231.2°C
• Density: 1.568g/cm³
• Vapor Pressure: 1.34E-08mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: (2-amino-5-bromophenyl)(4-chlorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-5-bromophenyl)(4-chlorophenyl)methanone(65246-99-3)
• EPA Substance Registry System: (2-amino-5-bromophenyl)(4-chlorophenyl)methanone(65246-99-3)

Safety Data

• Hazardous Substances Data: 65246-99-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-amino-5-bromophenyl)(4-chlorophenyl)methanone is utilized as a crucial intermediate in the synthesis of various pharmaceutical compounds. Its unique molecular structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Biology Research:
In the field of chemical biology, (2-amino-5-bromophenyl)(4-chlorophenyl)methanone is employed as a valuable tool for investigating the structure-function relationships of biologically relevant molecules. Its distinctive chemical properties facilitate a deeper understanding of molecular interactions and mechanisms.
Used in Organic Synthesis:
(2-amino-5-bromophenyl)(4-chlorophenyl)methanone is used as a versatile building block in organic synthesis, enabling the creation of a wide array of organic substances with diverse applications across various industries.

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 106-40-1 4-bromo-aniline 
• 887-90-1 5-bromo-3-(4-chlorophenyl)-2,1-benzisoxazole 
• 249765-58-0 [2-(methoxy(methyl)carbamoyl)phenyl]carbamic acid tert-butyl ester 
• 68790-38-5 2-(tert-butyloxycarbonylamino)benzoic acid 
• 118-92-3 anthranilic acid 
• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 1000994-79-5 C₁₈H₁₃BrClNO₂ 
• 1000995-01-6 C₁₈H₁₅BrClNO₄ 
• 1000995-03-8 C₁₉H₁₅BrClNO₃ 
• 1000995-02-7 C₁₇H₁₁BrClNO₃ 
• 1000994-80-8 C₁₉H₁₅BrClNO₂ 

Relevant articles and documents

BROMODOMAIN TARGETING DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides a Degronimer that has an E3 Ubiquitin Ligase targeting moiety (Degron) that can be linked to a Targeting Ligand for a bromodomain protein selected for in vivo degradation to achieve a therapeutic effect, and methods of use and compositions thereof as well as methods for their preparation.

DIHYDROQUINAZOLINONE ANALOGUES

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4 and A1 to A5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R4 and A1 to A5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of

New vistas in quinoline synthesis

The gold-catalyzed Friedlander reaction was applied to the condensation of 2-aminoarylketones with β-keto-esters, β-diketones, β-keto-amides, and β-keto-sulfones to afford a diverse range of 2,3,4-trisubstituted quinolines in 3-82% yield. The seven-membered rings 1,3-cycloheptadione and azepane-2,4-dione reacted smoothly in 75% yield. An alternative procedure for the synthesis of 3-(methanesulfonyl)quinolines was developed and provided an entry into late stage manipulation of the 4-position of these quinolines. The requisite 2-aminoarylketones for the Friedlander reaction were prepared in one pot by modified Sugasawa reaction using gallium(III) chloride and boron(III) chloride in 12-54% yield.

3-Methanesulfonylquinolines as GABAB enhancers

The present invention relates to compounds of formula I wherein R1, R2 and R3 are as defined in the specification, which are active at the GABAB receptor and which can be used for the treatment of CNS disorders.

SmI2-mediated facile one-pot preparation of 2,4-diarylquinolines from 3-aryl-2,1-benzisoxazoles

On treatment with SmI2, 3-aryl-2,1-benzisoxazoles undergo reductive cleavage of the N-O bond leading to 2-aminobenzophenones in high yields upon protonation. If aryl methyl ketones are added to the reaction mixture prior to protonation, the desired 2,4-diarylquinolines can be obtained in moderate yields under mild conditions.