66343-88-2Relevant academic research and scientific papers
Intramolecular Kinetic Deuterium Isotope Effects on Microsomal Hydroxylation and Chemical Chlorination of Toluene-α-d1 and Toluene-α,α-d2
Hanzlik, Robert P.,Hogberg, Kerstin,Moon, Joseph B.,Judson, Charles M.
, p. 7164 - 7167 (1985)
Deuterated toluenes PhCH2D and PhCHD2 were synthesized and subjected separately to microsomal hydroxylation in vitro.Mass spectral analysis of the resulting benzyl alcohols indicated substatial excess retention of deuterium, a consequence of the combined
Imidazopyrazinone compound as well as preparation method and application thereof
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Paragraph 0070; 0074; 0077-0078, (2021/10/11)
The invention provides an imidazopyrazinone compound as well as a preparation method and application thereof. The imidazopyrazinone compound structure has the structure shown I, and R. 1 Is phenyl. R2 In the benzyl group, and the compound has at least one D substituent, the D substituent is at R. 1 And/or R2 . The compound has excellent luminescence performance, can be used as a substrate of NanoLuc luminescent system, and is applied to detection and drug detection of luciferase.
Controlling Selectivity in the Synthesis of Z-α,β-Unsaturated Amidines by Tuning the N-Sulfonyl Group in a Rhodium(II) Catalyzed 1,2-H Shift
Boyer, Alistair,Martin, Matthew L.
supporting information, p. 5857 - 5861 (2021/11/27)
N2-Sulfonyl-α-diazo amidines can be synthesized by the reaction of electron rich alkynyl amines with electron poor sulfonyl azides through 1,3-dipolar cycloaddition that proceeds with perfect regioselectivity. In the presence of rhodium(II) carboxylate catalysts, denitrogenation occurs to give the corresponding metallocarbene but there are then two competing processes: 1,2–H shift and O-transfer from the sulfonyl group to the metallocarbene center. The outcome can be controlled using an electron poor nitrobenzenesulfonyl group and large carboxylate rhodium ligands to select for 1,2–H shift, forming α,β-unsaturated amidines in high yield and with excellent Z-selectivity.
Mechanistic analysis of oxidative C-H cleavages using inter- and intramolecular kinetic isotope effects
Jung, Hyung Hoon,Floreancig, Paul E.
experimental part, p. 10830 - 10836 (2010/02/28)
A series of monodeuterated benzylic and allylic ethers were subjected to oxidative carbon-hydrogen bond cleavage to determine the impact of structural variation on intramolecular kinetic isotope effects in DDQ-mediated cyclization reactions. These values
Mechanistic aspects of the reaction of anionic iron(0)-olefin complexes with organic halides. detection and characterization of paramagnetic organometallic intermediates
Hill, Dale H.,Parvez, Masood A.,Sen, Ayusman
, p. 2889 - 2901 (2007/10/02)
The scope and the mechanism of the reactions of [CpFe(COD)][Li(TMEDA) (Cp = C5H5-; COD = 1,5-cyclooctadiene; TMEDA = Me2NCH2CH2NMe2), 1, with a number of organic monohalides and geminal dih
Mechanistic analysis of the 3-methyllumiflavin-promoted oxidative deamination of benzylamine. A potential model for monoamine oxidase catalysis
Kim, Jong-Man,Bogdan, Michael A.,Mariano, Patrick S.
, p. 10591 - 10595 (2007/10/02)
An investigation designed to probe flavin-promoted oxidative deaminations of amines is described. 3-Methyllumiflavin (3MLF) has been found to promote clean conversion of benzylamine to N-benzylbenzaldimine under acid (HCl or MgCl2) catalyzed, t
Primary and Secondary Kinetic Deuterium Isotope Effects and Transition-State Structures for Benzylic Chlorination and Bromination of Toluene
Hanzlik, Robert P.,Schaefer, Angela R.,Moon, Joseph B.,Judson, Charles M.
, p. 4926 - 4930 (2007/10/02)
As a chemical model for benzylic hydroxylations effected by cytochrome P-450 enzymes, the chlorination of PhCH3, PhCH2D, PhCHD2, and PhCD3 in a two-phase system of hypochlorite/CH2Cl2 with a phase-transfer catalyst has been investigated.On the basis of th
