6774-47-6Relevant academic research and scientific papers
CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
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Paragraph 1233, (2018/04/17)
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
A 2-aryl-benzofuran-3-carboxylic acid preparation method of compound
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Paragraph 0033; 0036; 0037, (2017/03/14)
The invention belongs to the technical field of chemical synthesis, and discloses a preparation method of a 2-arylbenzofuran-3-formic acid compound. The preparation method comprises following steps: a compound with 2-bromophenylacetic acid structures, a c
Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetherification under microwave conditions: Entry to 2-arylbenzofuran-3-carboxylic acids
Xu, Tianlong,Zhang, Ensheng,Wang, Dejian,Wang, Yan,Zou, Yong
, p. 4313 - 4324 (2015/05/13)
A convenient one-pot synthesis of 2-arylbenzofuran-3-carboxylic acids from (E)-2-(2-bromophenyl)-3-phenylacrylic acids via Cu-catalyzed consecutive hydroxylation and aerobic oxidative cycloetherification under microwave conditions has been developed. This protocol employed the reagent combination of Cu(OAc)2, 1,10-phen, and KOH in DMSO/H2O (1:1), all of which are cost-effective, readily available, and easily removable from the reaction mixture. Utilizing this synthetic protocol, various 2-arylbenzofuran-3-carboxylic acids as well as the natural product moracin M have been synthesized in satisfactory yields under mild conditions.
Synthesis of 3-carboxylated indoles through a tandem process involving cyclization of 2-ethynylanilines followed by CO2 fixation in the absence of transition metal catalysts
Inamoto, Kiyofumi,Asano, Narumi,Nakamura, Yuka,Yonemoto, Misato,Kondo, Yoshinori
supporting information; experimental part, p. 2622 - 2625 (2012/07/14)
In this study, a facile synthesis of 3-carboxylated indoles involving a tandem-type cyclization of 2-ethynylanilines and subsequent CO2 fixation at the 3-position of the indole ring is realized. The reaction proceeds efficiently at 65 °C under
Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters
Thasana, Nopporn,Prachyawarakorn, Vilailak,Tontoolarug, Sopchok,Ruchirawat, Somsak
, p. 1019 - 1021 (2007/10/03)
A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leading to 2-phenylbenzofuran-3-carboxylic acid.
