69643-73-8

Upstream product

• 98-88-4 benzoyl chloride 
• 251653-77-7 2-(2'-trimethylsilylethynyl)-benzamide 
• 3930-83-4 o-iodobenzamide 
• 524-38-9 N-hydroxyphthalimide 
• 3623-15-2 phenyl propargyl ketone 
• 98-86-2 acetophenone 
• 60580-41-8 2-(5-Phenyl-3-Isoxazolyl)Benzoic Acid 
• 83727-26-8 Methyl 2-(5-phenylisoxazol-3-yl)benzoate 
• 69053-95-8 o-Metohycarbonylbenzohydroximinoyl chloride 
• 69053-94-7 Methyl 2-(hydroximinomethyl)benzoate 
• 4001-73-4 2-Bromobenzamide 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 1207252-50-3 2-ethynylbenzylamide 

Relevant academic research and scientific papers

Stereoselective synthesis of 3-methyleneisoindolin-1-ones via base-catalyzed intermolecular reactions of electron-deficient alkynes with N -hydroxyphthalimides

Highly stereoselective intermolecular reactions of electron-deficient alkynes with N-hydroxyphthalimides for efficient construction of N-unprotected 3-methyleneisoindolin-1-ones have been developed through base catalytic strategies. The reaction of alkynoates with N-hydroxyphthalimides catalyzed by Bu3P in DMF at 150 °C gave the corresponding 3-methyleneisoindolin-1-ones with a (Z)-configuration, while the reaction of alkynoates with N-hydroxyphthalimides catalyzed by K2CO3 in DMF at 60°C gave the corresponding 3-methyleneisoindolin-1-ones with an (E)-configuration, and (Z)-3-methyleneisoindolin-1-ones were obtained when alkyne ketones reacted with N-hydroxyphthalimide.

Development of a Class of Easily Scalable, Electron-Deficient, Core-Extended Benzo-Fused Azadipyrromethene Derivatives ("MB-DIPY")

We have developed a new synthetic strategy for the preparation of a series of isoindolin-1-imines and isoindolin-1-ones from aromatic ketones and phthalonitrile. Self-condensation reactions of these isoindolin-1-imines led to the formation of a novel class of benzo-fused, highly electron-deficient core-extended azadipyrromethene chromophores ("MB-DIPY"). The influence of temperature, catalyst, and the template ions on the self-condensation reaction rate, yield, and stereoselectivity was examined in detail. New chromophores (sodium, zinc, and metal-free compounds) were characterized by NMR, UV-vis, fluorescence, high-resolution mass spectroscopies, and in many cases, X-ray crystallography. Their redox properties were probed by electrochemical and spectroelectrochemical approaches that revealed the remarkable electron-accepting nature of the new systems. Stepwise one- A nd two-electron reduction of the new MB-DIPYs and their zinc complexes was investigated by spectroscopic and spectroelectrochemical methods. Both one- A nd two-electron reduced forms of all zinc complexes studied have strong absorption in the near-infrared region up to a??1200 nm. Unusual spectroscopic and electrochemical properties of these dyes were correlated with their electronic structures and excited-state natures predicted by density functional theory (DFT) and time-dependent DFT calculations. Despite some structural similarities with well-known aza-BODIPYs, the new MB-DIPYs differ remarkably from them in spectroscopic and redox properties.

Iron Promoted Ring Opening and Ring Closing Cascade (ROCC) Reaction of Ortho-Carboxy-Isoxazoles Leading to Isoindolinone Derivatives

An efficient and convenient route for the synthesis of various functionalized 3-alkylidene isoindolin-1-ones is presented. The synthesis involves the ring opening and ring closing cascade (ROCC) reaction of ortho-carboxy-isoxazole using Fe/NH4Cl. This is the first report for the synthesis of 3-alkylidene isoindolin-1-one using Fe/NH4Cl.

Synthesis of 3-Alkylideneisoindolin-1-ones via Sonogashira Cyclocarbonylative Reactions of 2-Ethynylbenzamides

Cyclocarbonylative Sonogashira reactions of ortho-ethynylbenzamides have been investigated. The process is carried out under CO pressure, in the presence of a very small amount of PdCl2(PPh3)2 (0.4 mol %) as a catalytic precursor and without the need for

Heteroannulation through combined palladium catalysed and Friedel-Crafts reactions strategy: Synthesis of 3-alkylidene isoindolin-1-ones

The palladium-catalysed reactions of 2-iodobenzamides 1-5 with trimethylsilyl acetylene 6 led to 2-(2-trimethylsilyl)ethynyl benzamides 7-11 in excellent yields. The 2-(2-trimethylsilyl)ethynyl benzamides 7-11 underwent Friedel-Crafts reactions with acid

3-Phenacyl and phenacylidene phthalimidines and corresponding naphthoyl derivatives

Certain 3-phenacyl and phenacylidene phthalimidines, and the corresponding naphthoyl derivatives, are novel compounds which possess biological activity in the treatment of plants to control their growth.