7188-90-1

Upstream product

• 729-19-1 1-benzyl-3-phenyl-4,5-dihydro-1H-pyrazole 
• 112349-80-1 1,5-diphenyl-tetrahydro-pyrazolo[1,2-a]pyrazole-2,6-dicarboxylic acid 
• 121842-23-7 1,5-diphenyl-tetrahydro-pyrazolo[1,2-a]pyrazole-2,6-dicarboxylic acid dimethyl ester 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 100-39-0 benzyl bromide 
• 2458-26-6 5-phenyl-1H-pyrazole 
• 7318-33-4 cinnamaldehyde tosylhydrazone 
• 104-55-2 3-phenyl-propenal 
• 98-86-2 acetophenone 
• 450360-76-6 C₁₅H₁₆N₂ 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 100-52-7 benzaldehyde 
• 140-88-5 ethyl acrylate 

Relevant academic research and scientific papers

Divergent synthesis of 1,3,5-tri and 1,3-disubstituted pyrazoles under transition metal-free conditions

Pyrazole cores are common structural motifs existing in various agrochemicals and pharmaceuticals. Herein, a transition metal-free, three-component reaction of arylaldehydes, ethyl acrylate and N-tosylhydrazones is described, which leads to the formation of 1,3,5-trisubstituted and 1,3-disubstituted pyrazoles divergently under slightly different conditions. This journal is

Copper-Catalyzed aerobic intramolecular dehydrogenative cyclization of n,n-disubstituted hydrazones through C sp 3 -H functionalization

An aerobic activity: The title reaction proceeds through an oxidation/cyclization/aromatization sequence under an atmosphere of O 2 (see scheme; DBU=1,8-diazabicyclo[5.4.0]undec-7-ene, DCE=1,2-dichloroethane, DMS=dimethylsulfide). This coupling

Efficient one-pot synthesis of substituted pyrazoles

An efficient, one-pot synthesis of substituted pyrazoles from enones, hydrazides, and halides was developed. In comparison with the classical Knorr pyrazole synthesis, this methodology gave a different type of product (R 3≥R5). A range of substituted pyrazoles were prepared in good to high yields with complete regioselectivity.