71995-54-5

Basic information

• Product Name: CYCLOHEXYLOXY-ACETIC ACID
• Synonyms: CYCLOHEXYLOXY-ACETIC ACID;AKOS AU36-M54;2-(Cyclohexyloxy)acetic Acid;2-(Cyclohexyloxy)
• CAS NO: 71995-54-5
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.19
• Mol File: 71995-54-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 305.8°C at 760 mmHg
• Flash Point: 124.6°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.000183mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: CYCLOHEXYLOXY-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYLOXY-ACETIC ACID(71995-54-5)
• EPA Substance Registry System: CYCLOHEXYLOXY-ACETIC ACID(71995-54-5)

Safety Data

• Hazardous Substances Data: 71995-54-5(Hazardous Substances Data)

Usage

General Description

Cyclohexyloxy-acetic acid, also known as CHX-acetic acid, is a carboxylic acid compound with the chemical formula C8H14O3. It is a white crystalline powder that is often used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chemical has been studied for its potential use in the treatment of inflammation and pain, as well as its role in the production of prodrugs for controlled release of active pharmaceutical ingredients. Additionally, CHX-acetic acid has been investigated for its potential use in the synthesis of polymers and materials with specific properties. Overall, cyclohexyloxy-acetic acid is a versatile compound with a range of potential applications in the fields of pharmaceuticals, materials science, and organic chemistry.

InChI:InChI=1/C8H14O3/c9-8(10)6-11-7-4-2-1-3-5-7/h7H,1-6H2,(H,9,10)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 108-93-0 cyclohexanol 
• 79-08-3 bromoacetic acid 
• 105-36-2 ethyl bromoacetate 
• 57941-70-5 ethyl 2-(cyclohexyloxy)acetate 
• 3926-62-3 sodium monochloroacetic acid 
• 79-11-8 chloroacetic acid 
• 22096-22-6 sodium cyclohexanolate 
• 122-59-8 2-phenoxyacetic acid 

Downstream Products

• 98552-43-3 2-(cyclohexyloxy)acetamide 
• 1616074-90-8 2-(cyclohexyloxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide 
• 53067-04-2 2-(cyclohexyloxy)ethylchloride 
• 42604-09-1 (methoxymethoxy)cyclohexane 
• 1346127-39-6 2-(cyclohexyloxy)-N-{4-[({[(5-methyl-1,2,3-thiadiazol-4-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}acetamide 
• 90226-63-4 2-(cyclohexyloxy)ethylamine 
• 932-92-3 cyclohexyl ethyl ether 
• 86867-75-6 4-Methoxy-benzenesulfonic acid 3-cyclohexyloxy-2-oxo-propyl ester 
• 86867-74-5 Toluene-4-sulfonic acid 3-cyclohexyloxy-2-oxo-propyl ester 
• 86867-72-3 3-cyclohexyloxy-2-oxopropyl benzenesulfonate 
• 86867-78-9 3-cyclohexyloxy-1-diazo-2-propanone 
• 189955-80-4 cyclohexyloxy-acetic acid 2-(4-methanesulfonyl-phenyl)-1,1-dimethyl-2-oxo-ethyl ester 
• 191337-81-2 2-(cyclohexyloxy)acetyl chloride 
• 13629-93-1 Cyclohexyloxy-essigsaeure-vinylester 

Relevant articles and documents

Photosensitized Intermolecular Carboimination of Alkenes through the Persistent Radical Effect

An intermolecular, two-component vicinal carboimination of alkenes has been accomplished by energy transfer catalysis. Oxime esters of alkyl carboxylic acids were used as bifunctional reagents to generate both alkyl and iminyl radicals. Subsequently, addition of the alkyl radical to an alkene generates a transient radical for selective radical–radical cross-coupling with the persistent iminyl radical. Furthermore, this process provides direct access to aliphatic primary amines and α-amino acids by simple hydrolysis.

N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein X, a, b, C, D, L2,L3, Y1, Y2, R2, R4, R5, R6, z2, z4, z5, and z6 are as defined herein, and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to compounds for use in methods of inhibiting the ATF4 (activating transcription factor 4) pathway and treatment of disorders associated therewith, such as e.g. cancer, neurodegenerative diseases and many other diseases, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. Preferred compounds of the invention are N-(3-(2-(4-chlorophenoxy) acetamido)bicyclo[1.1.1]pentan-l-yl)-2-cyclobutane-l-carboxamide derivatives and related compounds.

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.