73889-98-2

Upstream product

• 103000-97-1 1-(3,20-dioxo-5α-pregnan-2ξ-yl)-pyridinium; bromide 
• 64-19-7 acetic acid 
• 17503-05-8 (4α,5)epoxy-5α-pregnan-3,20-dione 
• 17597-24-9 (4β,5)-epoxy-5β-pregnan-3,20-dione 
• 57968-14-6 Δ¹-5β-pregnen-20-one 
• 753497-21-1 17β-Δ¹-5β-pregnen-3,20-dione 
• 1162-54-5 dl-Δ^1,2-pregnadiene-3,20-dione 
• 168609-36-7 3β-acetoxy-14β.17βH-pregnen-(5)-one-(20) 
• 163061-04-9 3β-hydroxy-14β,17α-pregn-5-en-20-one 
• 56-23-5 tetrachloromethane 
• 93-59-4 Perbenzoic acid 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 556-91-2 aluminum tri-tert-butoxide 

Downstream Products

• 7093-55-2 5-pregnene-3,20-dione-3,20-bisethyleneketal 
• 58-22-0 testosterone 
• 16031-66-6 14-hydroxy-4-pregnene-3,20-dione 
• 63-05-8 Androstenedione 
• 145-14-2 (20S)-20-hydroxypregn-4-en-3-one 
• 68-96-2 17-hydroxyprogesterone 
• 600-57-7 (8S,9S,10R,11S,13S,14S,17S)-17-Acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 145-15-3 20α-hydroxyprogesterone 
• 7217-07-4 4-pregnene-3β,20β-diol 
• 80-75-1 11-alpha-hydroxyprogesterone 
• 599-14-4 12β,15α-Dihydroxyprogesterone 
• 1162-56-7 6-dehydroprogesterone 
• 1171-90-0 3,20-dioxo-pregna-1,4-dien-21-yl acetate 
• 897-06-3 Androsta-1,4-diene-3,17-dione 

Relevant academic research and scientific papers

Alternative synthetic approaches to rac-progesterone by way of the classic Johnson cationic polycyclization strategy

Three alternative synthetic entries into Johnson's classic synthesis of rac-progesterone are presented in this manuscript. ent-Progesterone, the non-natural enantiomer of progesterone, has recently been identified as a potential alternative to progesterone for investigations into possible prevention and treatment of traumatic brain injury (TBI). Difficulties in accessing ent-progesterone in large quantities prevent it from being studied more thoroughly. Strategies for producing synthetic rac-progesterone are described and discussed herein.

Direct Formation of the Steroid Nucleus by a Biomimetic Cyclization

The aim of this study was to synthesize the trienynol 3 and to study its cyclization.The substrate was synthesized by a convergent route, the key step being the stereoselective Wittig-Schlosser condensation of the known aldehyde 19 with the phosphorane 18

Structural requirements for progestational activity. Synthesis and properties of rac-8α,9β,10α,14β-progesterone

rac-8α,9β,10α,14β-progesterone, 1, has been synthesized and subjected to X-ray crystallographic analysis which established that the ring conformations are A, 1β-sofa; B, chair; C, chair; and D, intermediate between an envelope and a half-chair. This compound is 10% as active as progesterone in the Clauberg assay and has an affinity for the uterine cytosol (rabbit) receptor for progesterone 2% as great as that of progesterone.