74587-15-8

Basic information

• Product Name: benzyl (4-methoxyphenyl)acetate
• CAS NO: 74587-15-8
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.2964
• Mol File: 74587-15-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 374.8°C at 760 mmHg
• Flash Point: 157.2°C
• Density: 1.129g/cm³
• Vapor Pressure: 8.13E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: benzyl (4-methoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (4-methoxyphenyl)acetate(74587-15-8)
• EPA Substance Registry System: benzyl (4-methoxyphenyl)acetate(74587-15-8)

Safety Data

• Hazardous Substances Data: 74587-15-8(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 100-51-6 benzyl alcohol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 15175-54-9 N,N-dimethyl-4-methoxylbenzylamine 
• 201230-82-2 carbon monoxide 
• 1416982-07-4 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 100-39-0 benzyl bromide 
• 30379-58-9 benzyl glycolate 
• 93296-09-4 4-methoxyphenylzinc chloride 

Downstream Products

• 325793-19-9 benzyl 2-(4-methoxylphenyl)-2-oxoacetate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 1374152-30-3 benzyl 2-diazo-2-(4-methoxyphenyl)acetate 
• 293731-62-1 (αR,3'R)-4',4'-dimethyl-γ-butyrolacton-3'-yl 2-(4-methoxyphenyl)-3-phthalimidopropanoate 
• 293731-63-2 (αS,3'R)-4',4'-dimethyl-γ-butyrolacton-3'-yl 2-(4-methoxyphenyl)-3-phthalimidopropanoate 
• 293731-58-5 (RS)-2-(4-methoxyphenyl)-3-phthalimidopropanoic acid chloride 
• 293731-54-1 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(4-methoxyphenyl)propanoic acid 
• 512176-83-9 benzyl 2-benzoyl-2-(4-methoxyphenyl)propanoate 
• 35572-39-5 (S)-2-(4-methoxyphenyl)-1-phenylpropan-1-one 
• 512176-71-5 benzyl 2-benzoyl-2-(4-methoxyphenyl)ethanoate 
• 293731-50-7 (RS)-benzyl 2-(4-methoxyphenyl)-3-phthalimidopropanoate 
• 1657-55-2 1,2-bis(4-methoxyphenyl)ethane 
• 14310-21-5 1-(4-methoxyphenyl)-2-phenylethane 

Relevant articles and documents

Ni-Catalyzed C(sp3)–O Arylation of α-Hydroxy Esters

A Negishi cross-coupling of α-hydroxy ester derivatives and arylzinc reagents has been developed. This reaction tolerates both primary and secondary C(sp3)–O alcohol precursors and achieves efficient cross-coupling under Ni catalysis without the need for added external metal reductant, photocatalyst, or additives. The arylation of readily accessible C(sp3)–O electrophiles in this operationally simple, rapid, and mild reaction provides a complementary way of accessing desirable α-aryl ester products.

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

Catalysed asymmetric protonation of simple linear keto-enolic species a route to chiral α-arylpropionic acids

The reaction cascade consisting of deprotection/decarboxylation/asymmetric protonation of enolic species, starting from open-chain benzyl β-oxo esters, has been studied. When carried out in the presence of catalytic amounts of cinchonine, the reaction gave optically active α-aryl ketones with up to 75% ee. Enantio-enriched (S)-3-phenyl-2-butanone can be converted into 2-phenylpropionic acid without racemisation. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.