75052-53-8

Upstream product

• 100-42-5 styrene 
• 67-56-1 methanol 
• 7647-01-0 hydrogenchloride 
• 75-09-2 dichloromethane 
• 7790-99-0 Iodine monochloride 
• 60-29-7 diethyl ether 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 

Relevant academic research and scientific papers

TEMPO-Regulated Regio- and Stereoselective Cross-Dihalogenation with Dual Electrophilic X+ Reagents

A TEMPO catalyzed cross-dihalogenation reaction was established via redox-regulation of the otherwise complex system of dual electrophilic X+ reagents. Formally, the ICl, BrCl, I2 and Br2 were generated in-situ, which enabled high regio- or stereoselective access to a myriad of iodochlorination, bromochlorination and homo-dihalogenation products with a wide spectrum of functionalities. With its mild conditions and operational simplicity, this method could enable wide applications in organic synthesis, which was exemplified by divergent synthesis of two pharmaceuticals. Detailed mechanistic investigations via radical clock reaction, pinacol ring expansion and Hammett experiments were conducted, which confirmed the intermediacy of halonium ion. In addition, a dynamic catalytic model based on the versatile catalytic role of TEMPO was proposed to explain the selective outcomes.

Dihalogenation of Alkenes Using Combinations of N-Halosuccinimides and Alkali Metal Halides

A simple, efficient and eco-friendly method for the vicinal dihalogenation of alkenes is described. The reaction is performed with a combination of a N-halosuccinimide and an alkali metal halide using environmentally benign solvents such as acetic acid an

Substrate-Controlled Regioselective Iodooxygenation of Olefins

An unexpected regioselective I 2 /TBHP-mediated 1,2-iodooxygenation of alkenes with N -hydroxylamines is described. The reaction proceeds through a radical coupling mechanism or a iodonium mechanism, which is controlled by the structures of bot

Method for synthesizing 1- chlorine-2-dihalogenated iodine

The invention discloses a method for synthesizing 1-chlorine-2-dihalogenated iodine as shown in formula (IV). The method comprises the following steps: mixing an olefin compound as shown in formula (I), an iodine source, tert-butyl hydroperoxide as shown

Dihaloiodates(I): Synthesis with hydrogen peroxide and their halogenating activity

Tetraalkylammonium and pyridinium dichloro- and dibromoiodates(I) were efficiently prepared from iodine and tetralkylammonium chloride or pyridine by oxidation with hydrogen peroxide in the presence of an equimolar amount of a hydrogen halide. Their halogenating activity was tested on 1,3-dimethoxybenzene and styrene as model substrates. The results show that ICl2 - salts acted as iodinating reagents, while IBr2 - salts brominated both substrates. 2012 Elsevier Ltd. All rights reserved.

Conformationally restricted aza-BODIPY: Highly fluorescent, stable near-infrared absorbing dyes

Novel NIR fluorescent, conformational restricted aza-dipyrromethene boron difluoride (aza-BODIPY) dyes were prepared by an efficient process. Such conformational restricted aza-BODIPY dyes possess intense absorption, strong fluorescence, high chemical and

4,4′-Bis(dichloroiodo)biphenyl and 3-(dichloroiodo)benzoic acid: New recyclable hypervalent iodine reagents for vicinal halomethoxylation of unsaturated compounds

4,4′-Bis(dichloroiodo)biphenyl and 3-(dichloroiodo)benzoic acid are convenient recyclable hypervalent iodine reagents for vicinal chloromethoxylation or iodomethoxylation of unsaturated compounds. The reactivity of these reagents in the reaction of vicinal halomethoxylation is generally similar to dichloroiodobenzene and the advantage of their use is that the reduced forms of these reagents can be easily separated from the reaction mixture and reused for the regeneration of the reagents.

(Dichloroiodo)benzene - An Easily Available Reagent for Chloro- and Iodoalkoxylation, Iodohydroxylation, and Iodochlorination of Alkenes

A convenient synthesis of vicinal methoxychlorides, methoxyiodides, iodhydrines and iodochloride from alkenes using PhICl2/CH 3OH, I2/ PhICl2/CH3OH, I 2/PhICl2/CH3CN/H2O and I 2/PhICl2/CH2Cl2 is described.

Ionic reaction of halogens with terminal alkenes: The effect of electron-withdrawing fluorine substituents on the bonding of halonium ions

Ionic reactions of terminal alkenes with chlorine (Cl2), bromine (Br2), and iodine monochloride (ICI) are sensitive to the alkyl substituents, and the positions and number of vinyl fluorine atoms. These perturbations influence the symmetry of the halonium ion intermediates, which can be determined by the distribution of the Markovnikov to anti-Markovnikov products. A vinyl fluorine on the number-2 carbon favors an unsymmetrical intermediate with greater charge on the number-2 carbon unless the alkyl group is electron withdrawing. A vinyl fluorine on the terminal number-1 carbon favors positive charge development on that carbon unless a resonance stabilizing group is on the number-2 carbon. The symmetry of halonium ions with vinyl fluorines on both carbons-1 and -2 depends primarily on the characteristics of the alkyl substituent. Intermediates range from openions with the positive charge on carbon-2, to various bridged species, to open-ions on the terminal carbon.

New electrophilic iodochlorinating systems based on iodine(+1)

Two new convenient systems for electrophilic iodochlorination of olefins are proposed: KIO3 + I2 + HCl (in aqueous solutions) and KICl4 + I2 (in organic solvents).