75553-28-5

Upstream product

• 15733-63-8 5-chloropentylbenzene 
• 127-08-2 potassium acetate 
• 10521-91-2 5-phenylpentan-1-ol 
• 75-36-5 acetyl chloride 
• 591-50-4 iodobenzene 
• 15848-22-3 5-bromo-1-pentanyl acetate 
• 2996-92-1 phenyl trimethylsiloxane 
• 104-53-0 3-phenyl-propionaldehyde 
• 108-24-7 acetic anhydride 
• 141-78-6 ethyl acetate 
• 65921-65-5 5-iodopentyl acetate 
• 100-59-4 phenylmagnesium chloride 
• 64-19-7 acetic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 10521-91-2 5-phenylpentan-1-ol 
• 14469-83-1 (5-bromopentyl)benzene 
• 135832-50-7 4-(5-Hydroxy-pentyl)-benzenesulfonamide 
• 135832-51-8 Acetic acid 5-(4-sulfamoyl-phenyl)-pentyl ester 
• 1021867-26-4 4'-(5-acetoxypentyl)propiophenone 
• 1421737-86-1 5-(2,4-dinitrophenyl)pentan-1-ol 

Relevant academic research and scientific papers

Novel access to carbonyl and acetylated compounds: The role of the tetra-: N -butylammonium bromide/sodium nitrite catalyst

A novel aerobic oxidation of alcohols without the use of any oxidants was developed. An equimolar catalytic mixture of tetra-n-butylammonium bromide and sodium nitrite catalyzes the aerobic selective oxidation of benzylic alcohols under oxidant-free, base-free and metal-free conditions. The mild reaction conditions allow oxidation of a wide range of benzylic alcohols, chemo-selectively to their carbonyl compounds (68-93% isolated yields). More importantly, high selectivity among different kinds of alcohols (aromatic vs. aliphatic alcohols, primary vs. secondary alcohols as well as alcohols having neutral rings vs. electron-deficient rings) is available by this approach. The method surprisingly switched over to be an efficient acetylation approach in the case of aliphatic alcohols without the use of any transition metal, phosphorous or other toxic reagents or any need for using toxic acyl halides, sulfonyl halides, anhydrides, etc. by the use of only acetic acid as a reagent.

Cross-coupling of nonactivated primary and secondary alkyl halides with aryl Grignard reagents catalyzed by chiral iron pincer complexes

Iron(III) bisoxazolinylphenylamido (bopa) pincer complexes are efficient precatalysts for the cross-coupling of nonactivated primary and secondary alkyl halides with phenyl Grignard reagents. The reactions proceed at room temperature in moderate to excellent yields. A variety of functional groups can be tolerated. The enantioselectivity of the coupling of secondary alkyl halides is low.

Visible-light-promoted conversion of alkyl benzyl ether to alkyl ester or alcohol via O-α-sp3 C-H cleavage

A mild and high-yielding visible-light-promoted conversion of alkyl benzyl ethers to the alkyl esters or alkyl alcohols was developed. Mechanistic studies provided evidence for a radical chain reaction involving the homolytic cleavage of O-α-sp3 C-H bonds in the substrate as one of the propagation steps. We propose that α-bromoethers are key intermediates in the transformation.

PHOTOALIGNING MATERIALS

The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, comprising a main chain and a side chain, wherein the side chain and/or main chain comprises a polar group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).

PHOTOALIGNING MATERIALS

The present invention relates to polymer, homo- or copolymer or oligomer, which, when irradiated with polarised light orients perpendicular to the polarization direction of polarized actinic light, for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, and which derives from at least one monomer (I), compositions thereof, and its use for optical and electro optical devices, such as, liquid crystal devices (LCDs), especially for planar orientation of liquid crystals.

Halogenation of primary alcohols using a tetraethylammonium halide/[Et 2NSF2]BF4 combination

The halogenation of primary alcohols is presented. The use of a combination of tetraethylammonium halide and [Et2NSF2]BF4 (XtalFluor-E) allows for chlorination and bromination reactions to proceed efficiently (up to 92% yield) with a wide range of alcohols. Iodination reactions are also possible albeit in lower yields.

Methoxy- and fluorine-substituted analogs of O-1302: Synthesis and in vitro binding affinity for the CB1 cannabinoid receptor

Methoxy and fluorine analogs substituted on the terminal carbon of the pentyl chain of N-(piperidinyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4- pentylphenyl)-1H-pyrazole-3-carboxamide (O-1302) were synthesized in a multi-step process from 5-phenyl-1-pentanol, which was based on the 1,5-diarylpyrazole core template of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) through condensation of the respective amine with pyrazole carboxylic acid, in order to develop tracers for medical imaging. Their potency for inhibiting the binding of the CB1 antagonist [3H]SR141716 was evaluated with the aim of developing positron emission tomography (PET) ligands for the cerebral cannabinoid CB1 receptor. These analogs bearing a piperidinyl carboxamide at the C3 of the pyrazole ring exhibited affinities comparable to those of the CB1 reference antagonist SR141716, which warrants further investigation using the radiolabeled form for biological imaging studies. A morpholine ring substituted at the C3 of the pyrazole ring resulted in a reduction of the CB1 affinity.

Room-temperature Hiyama cross-couplings of arylsilanes with alkyl bromides and iodides

The first method for achieving Hiyama couplings of unactivated alkyl bromides and iodides is reported. The desired carbon-carbon bond formation proceeds under mild conditions (room temperature) with good functional-group tolerance. Copyright

Highly efficient, general procedure for the preparation of alkylzinc reagents from unactivated alkyl bromides and chlorides

(Matrix presented) Alkylzinc bromides have been efficiently prepared by the direct insertion of zinc metal (dust, powder, granule, shot), activated with 1-5 mol % I2, into alkyl bromides in a polar aprotic solvent. The zinc reagents thus formed undergo Ni- and Pd-catalyzed cross-coupling with aryl halides to produce functionalized alkylarenes in excellent yields.

Neue Cobalt- und Eisen-katalysierte Reaktionen mit Organozinkverbindungen

Keywords: Acylierungen; Allylierungen; Cobaltverbindungen; Katalyse; Zinkverbindungen