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77-89-4

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Product FOB Price Min.Order Supply Ability Supplier
Triethyl acetyl citrate
Cas No: 77-89-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Triethyl acetyl citrate
Cas No: 77-89-4
USD $ 13.0-19.0 / Kilogram 25 Kilogram 100000 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
Acetyl triethyl citrate
Cas No: 77-89-4
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Factory price Cosmetic ACETYL TRIETHYL CITRATE 77-89-4 Manufacturer
Cas No: 77-89-4
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply Triethyl O-acetylcitrate
Cas No: 77-89-4
No Data 1 1 Ality Chemical Corporation Contact Supplier
Triethyl acetyl citrate(ATEC)
Cas No: 77-89-4
No Data 1 Metric Ton 100 Metric Ton/Month EAST CHEMSOURCES LIMITED Contact Supplier
triethyl O-acetylcitrate
Cas No: 77-89-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Triethyl acetyl citrate
Cas No: 77-89-4
USD $ 1.0-1.0 / Kilogram 1 Kilogram 2000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
Triethyl acetyl citrate
Cas No: 77-89-4
USD $ 0.9-1.0 / Kilogram 1 Kilogram 10000 Kilogram/Month LIDE PHARMACEUTICALS LIMITED Contact Supplier
New StandardCAS 77-89-4 with high quality products
Cas No: 77-89-4
USD $ 146.0-176.0 / Gram 10 Gram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier

77-89-4 Usage

Safety

Acetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful. LD50 (cat, oral): 8.5 g/kg LD50 (mouse, IP): 1.15 g/kg LD50 (rat, oral): 7 g/kg

Regulatory Status

Approved in the USA for direct food contact in food films.

Production Methods

Acetyltriethyl citrate is prepared by the esterification of citric acid with ethanol followed by acylation with acetic anhydride.

Chemical Properties

Acetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.

storage

Acetyltriethyl citrate should be stored in dry, closed containers at temperatures not exceeding 388℃. When stored in accordance with these conditions, acetyltriethyl citrate is a stable product.

Uses

ATEC is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is used as a solvent plasticizer for cellulose nitrate and cellulose acetate.

Incompatibilities

Acetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.

Pharmaceutical Applications

Acetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations. It is also used in diffusion-controlled release drug delivery systems.

Definition

Aqueous-based pharmaceutical coat- ings.
InChI:InChI=1/C14H22O8/c1-5-19-11(16)8-14(22-10(4)15,13(18)21-7-3)9-12(17)20-6-2/h5-9H2,1-4H3

77-89-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1009923)  Acetyltriethylcitrate  United States Pharmacopeia (USP) Reference Standard 77-89-4 1009923-500MG 4,662.45CNY Detail

77-89-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Triethyl O-Acetylcitrate

1.2 Other means of identification

Product number -
Other names triethyl 2-acetyloxypropane-1,2,3-tricarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77-89-4 SDS

77-89-4Synthetic route

citric acid triethyl ester
77-93-0

citric acid triethyl ester

acetic anhydride
108-24-7

acetic anhydride

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Conditions
ConditionsYield
With 4-(dimethylamino)pyridine hydrochloride at 110℃; for 8h;90%
sulfuric acid at 80℃; for 3h;88%
With H-type zeolite catalyst at 60 - 120℃; under 760.051 Torr; for 2.83333h; Reagent/catalyst; Sealed tube; Inert atmosphere;
unter kontinuierlicher Entfernung der entstehenden Essigsaeure;
citric acid triethyl ester
77-93-0

citric acid triethyl ester

acetyl chloride
75-36-5

acetyl chloride

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Diethyl-3-(ethoxycarbonyl)pent-2-endioat
5349-99-5

Diethyl-3-(ethoxycarbonyl)pent-2-endioat

Conditions
ConditionsYield
at 275℃; for 1.5h;89%
at 270℃; under 760.051 Torr; for 0.4h;74%
at 250 - 280℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

1 propene 1,2,3 tricarboxylic acid
499-12-7

1 propene 1,2,3 tricarboxylic acid

Conditions
ConditionsYield
at 250 - 280℃; ueberdestilliert die Essigsaeure, dann verseift man mit konz.Salzsaeure und destilliert diese unter vermindertem Druck ab;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

2,6-dihydroxy-isonicotinic acid amide
14533-64-3

2,6-dihydroxy-isonicotinic acid amide

Conditions
ConditionsYield
With ammonium hydroxide
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

A

acetic acid
64-19-7

acetic acid

B

aconitic acid triethyl ester

aconitic acid triethyl ester

Conditions
ConditionsYield
at 250 - 280℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

ammonium hydroxide

ammonium hydroxide

citrazinamide

citrazinamide

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Diethyl-2-oxo-2H-pyran-4,5-dicarboxylat
101967-99-1

Diethyl-2-oxo-2H-pyran-4,5-dicarboxylat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89 percent / 1.5 h / 275 °C
2: 45 percent / TiCl4, 4-Methylmorpholine / tetrahydrofuran; CCl4 / 20 h / Ambient temperature
3: HCOOH / 1 h / 95 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 0.4 h / 270 °C / 760.05 Torr
2.1: titanium tetrachloride / tetrachloromethane; tetrahydrofuran / 0.5 h / 0 °C
2.2: 20 h / 0 - 20 °C
3.1: formic acid / 1 h / 100 °C
View Scheme
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

Diethyl-3-(ethoxycarbonyl)-4-(ethoxymethylen)pent-2-endioat
129256-95-7

Diethyl-3-(ethoxycarbonyl)-4-(ethoxymethylen)pent-2-endioat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / 1.5 h / 275 °C
2: 45 percent / TiCl4, 4-Methylmorpholine / tetrahydrofuran; CCl4 / 20 h / Ambient temperature
View Scheme
propylamine
107-10-8

propylamine

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

A

n-propylacetamide
5331-48-6

n-propylacetamide

B

(Z)-3-acetyl-5-oxo-N-propylhex-2-enamide
1242516-61-5

(Z)-3-acetyl-5-oxo-N-propylhex-2-enamide

C

(Z)-3-((propylcarbamoyl)-methylene)-4-oxopentanoic acid
1242516-60-4

(Z)-3-((propylcarbamoyl)-methylene)-4-oxopentanoic acid

D

(Z)-3,4-bis(propylcarbamoyl)but-3-enoic acid
1242516-62-6

(Z)-3,4-bis(propylcarbamoyl)but-3-enoic acid

E

1,2,3-tris(propylcarbamoyl)propyl-2-yl acetate

1,2,3-tris(propylcarbamoyl)propyl-2-yl acetate

Conditions
ConditionsYield
In methanol at 20℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

N-butylamine
109-73-9

N-butylamine

A

N-butylacetamide
1119-49-9

N-butylacetamide

B

1,2,3-tris(butylcarbamoyl)propan-2yl acetate
1242516-63-7

1,2,3-tris(butylcarbamoyl)propan-2yl acetate

Conditions
ConditionsYield
In methanol at 20℃;
methanol
67-56-1

methanol

triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

tert-butylamine
75-64-9

tert-butylamine

A

trimethyl citrate
1587-20-8

trimethyl citrate

B

citric acid triethyl ester
77-93-0

citric acid triethyl ester

C

dimethyl 3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioate
1242516-65-9

dimethyl 3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioate

D

3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioic acid
1242516-64-8

3-(tertbutylcarbamoyl)-3-acetoxy-pentanedioic acid

Conditions
ConditionsYield
at 20℃;
triethyl O-acetylcitrate
77-89-4

triethyl O-acetylcitrate

triethyl 4-ethoxybuta-1,3-diene-1,2,3-tricarboxylate

triethyl 4-ethoxybuta-1,3-diene-1,2,3-tricarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 0.4 h / 270 °C / 760.05 Torr
2.1: titanium tetrachloride / tetrachloromethane; tetrahydrofuran / 0.5 h / 0 °C
2.2: 20 h / 0 - 20 °C
View Scheme
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