78604-82-7Relevant academic research and scientific papers
Catalyst-free facile and efficient one-pot synthesis of densely functionalized pyrroles and α-amino ketones
Vanga, Sivarama Krishna Reddy,Bollikolla, Hari Babu,Peruri, V. V. Satyanarayana
supporting information, p. 892 - 899 (2021/02/01)
An efficient catalyst-free one-pot three-component synthesis of penta-substituted pyrroles has been successfully developed. A variety of penta-substituted pyrroles were straightforwardly synthesized from good to excellent yields (78%–93%) by using easily
Synthesis and lung cancer cell line study of pyrrolo[2,3-d]pyrimidine analogs
Dholakia, Sandip P.,Kanada, Kaushik B.,Sureja, Dipen K.,Patel, Jitendra S.
, p. 367 - 372 (2020/01/03)
Three series of new pyrrolo[2,3-d]pyrimidines having diverse groups at position C4 and N7 of the pyrrolo[2,3-d]pyrimidine core were synthesized and their cell line study on the National Cancer Institute (NCI) H1 299 lung cancer cell line was performed. The details of the synthetic methods and characterization data of the synthesized compounds have been presented in this study. Compounds 08a, 08h, 08j, 09h, 09i, 09j, 09m, 09n, and 09o showed excellent anticancer activity compared to standard doxorubicin half maximal inhibitory concentration value on NCI H1 299 (lung cancer cell line) which was nontoxic to normal Vero cell line.
SnCl2·2H2O-Catalyzed Solvent-Free Synthesis of α-Amino Ketones and Tetrasubstituted Pyrazines
Tamaddon, Fatemeh,Dehghani Tafti, Arefeh
, p. 2217 - 2220 (2016/10/11)
Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl2·2H2O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl2·2H2O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.
Novel antiviral compounds against gastroenteric viral infections
Mohamed, Mosaad S.,El-Hameed, Rania H. Abd,Sayed, Amira I.,Soror, Sameh H.
, p. 194 - 205 (2015/03/14)
Viral gastroenteritis is a serious viral infection which affects a large number of individuals around the world, most of them being children. The infection may occur due to different viruses, for example, coxsackievirus, adenovirus, and rotavirus. There i
Highly stereoselective synthesis of β-amino ketones via a mannich reaction catalyzed by cellulose sulfuric acid as a biodegradable, efficient, and recyclable heterogeneous catalyst
Nemati, Firouzeh,Fakhaei, Amir Soheyl,Amoozadeh, Ali,Hayeniaz, Yaser Saeidi
experimental part, p. 3695 - 3702 (2011/10/09)
The efficient use of cellulose sulfuric acid as a heterogeneous catalyst promotes three-component, one-pot Mannich reaction of various ketones, aromatic aldehydes, and aromatic amines in ethanol to make the corresponding β-amino ketones with high stereose
Thiazolium-derived N-heterocyclic carbene-catalyzed cross-coupling of aldehydes with unactivated imines
Li, Gong-Qiang,Dai, Li-Xin,You, Shu-Li
, p. 852 - 854 (2007/10/03)
Cross-coupling of aromatic aldehydes or benzoins with unactivated imines catalyzed by an N-heterocyclic carbene (NHC) affords α-amino ketones smoothly. The Royal Society of Chemistry.
Chemoselective reduction of α-imino carbonyl compounds into α-amino carbonyl compounds with titanium tetraiodide
Shimizu, Makoto,Sahara, Tetsuya,Hayakawa, Ryuuichirou
, p. 792 - 793 (2007/10/03)
α-Imino carbonyl compounds are chemoselectively reduced with titanium tetraiodide to give α-amino carbonyl compounds in good to excellent yields.
Ruthenium clay catalyzed reduction of α-iminoesters and α-iminoketones, and the reductive amination of α-ketoesters
Aldea, Raluca,Alper, Howard
, p. 454 - 457 (2007/10/03)
The reduction of α-iminoesters and α-iminoketones to the corresponding amino compounds was accomplished using ruthenium clay as the catalyst, at 75-100°C and 600-900 psi H2. The same catalyst proved efficient for the reductive amination of α-ketoesters (100°C, 600 psi H2). Diastereomeric excesses of up to 78% were obtained in the reductive amination reaction.
Synthesis and characterization of 9,10-bis(arylimino)-9,10-dihydrophenanthrenes, the structure of (Z,Z)-9,10-bis(phenylimino)-9,10-dihydrophenanthrene and PdCl2-[(E,E)-9,10-bis(phenylimino)-9,10-dihydrophenanthrene] in the solid state and in so
Van Belzen, Ruud,Klein, Rene A.,Smeets, Wilberth J.J.,Spek, Anthony L.,Benedix, Roland,Elsevier, Cornelis J.
, p. 275 - 285 (2007/10/03)
The synthesis and characterization of substituted phenanthrene-9,10-quinone diimines of the type 9,10-bis(arylimino)-9,10-dihydrophenanthrene (aryl-BIP) is described. These rigid bisnitrogen ligands have been synthesized by a metal-mediated cyclodehydroge
Stereochemistry of Imino-group Reduction. Part 3. The Hydride Reduction of Achiral Benzil Monoimines
Alcaide, Benito,Lopez-Mardomingo, Carmen,Perez-Ossorio, Rafael,Plumet, Joaquin
, p. 1649 - 1654 (2007/10/02)
The RR,SS:RS,SR ratio of diastereoisomeric amino-alcohols obtained from the lithium aluminium hydride reduction of the monoimines prepared by reaction of benzil and various aliphatic and aromatic achiral amines has been determined.Stereochemical results a
