80012-16-4

Basic information

• Product Name: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2E)-
• CAS NO: 80012-16-4
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol File: 80012-16-4.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2E)-(80012-16-4)
• EPA Substance Registry System: 2-Propen-1-one, 3-amino-1,3-diphenyl-, (2E)-(80012-16-4)

Safety Data

• Hazardous Substances Data: 80012-16-4(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 536-74-3 phenylacetylene 
• 631-61-8 ammonium acetate 
• 120-46-7 1,3-diphenylpropanedione 
• 16717-64-9 1-azidostyrene 
• 611-73-4 Benzoylformic acid 
• 14947-61-6 boron difluoride 1,3-diphenylpropane-1,3-dionate 
• 100-47-0 benzonitrile 
• 93-91-4 1-phenylbutan-1,3-dione 
• 93-58-3 benzoic acid methyl ester 
• 98-86-2 acetophenone 
• 698-16-8 benzohydroximoyl chloride 
• 4070-75-1 1,4-diphenyl-but-2-ene-1,4-dione 

Downstream Products

• 51851-43-5 C₂₇H₂₂BNO 
• 51851-44-6 C₁₅H₁₂BF₂NO 
• 16232-42-1 2-oxo-4,6-diphenyl-1,2-dihydropyridine-3-carbonitrile 
• 1145-01-3 3,5-Diphenylpyrazole 
• 19311-79-6 1-methyl-3,5-diphenyl-1H-pyrazole 
• 2183-27-9 1,3,5-triphenyl-1H-pyrazole 
• 3920-15-8 3,5-diphenylisothiazole 
• 35529-46-5 3,4,5-Triphenylisothiazole 
• 54605-80-0 4-benzoyl-2-hydroxy-2,5-diphenyl-1,2-dihydro-3H-pyrrol-3-one 

Relevant articles and documents

Metal-Free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines

A concise and efficient synthetic method for alkynyl quinolines through TfOH-promoted cascade 1,4-conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza-o-AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition-metal-free process features halogen groups tolerance, such as the ?Cl, ?Br, and ?I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.

Iodine-Promoted Formal [3+2] Cycloaddition of Enaminone: Access to 2-Hydroxy-1,2-dihydro-pyrrol-3-ones with Quaternary Carbon Center

A novel iodine promoted cyclization of enaminone with aryl methyl ketones has been developed as a straightforward method for constructing 2-hydroxy-pyrrol-3(2H)-ones. This strategy affords structurally diverse 2-hydroxy-pyrrol-3(2H)-ones rings in high yields. Moreover, a quarternary alcohol has been constructed efficiently in the reaction. Product purification required only washing with CH2Cl2 solvent, thereby avoiding traditional chromatography and recrystallization, making this an example of group-assisted purification chemistry.

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