81992-90-7

Upstream product

• 183874-14-8 2-Benzyl-4-chloro-N-phenyl-benzamide 
• 100-39-0 benzyl bromide 
• 7758-99-8 copper(II) sulfate 
• 33184-56-4 2-benzoyl-4-chlorobenzoic acid 
• 6833-15-4 4-chlorobenzanilide 
• 124-38-9 carbon dioxide 
• 100397-76-0 2-benzyl-1-bromo-4-chlorobenzene 

Downstream Products

• 1456693-86-9 5-chloro-3-hydroxy-2-methoxy-3-phenylisoindolin-1-one 
• 1154058-94-2 2-Benzyl-4-chloro-N-(2-sulfamoylphenyl)sulfonyl-benzamide 
• 131-09-9 2-chloroanthracene-9,10-dione 
• 21143-53-3 methyl 2-benzyl-4-chlorobenzoate 
• 21143-57-7 (2-Benzyl-4-chloro-phenyl)-acetic acid 
• 21143-56-6 (2-Benzyl-4-chloro-phenyl)-acetonitrile 
• 21143-55-5 2-Benzyl-1-bromomethyl-4-chloro-benzene 
• 21143-54-4 2-Benzyl-4-chlorobenzyl alcohol 

Relevant academic research and scientific papers

Application of Organolithium and Related Reagents in Synthesis XVI: Synthetic Strategies Based on Aromatic Metallation. A Concise Regiospecific Conversion of Chlorobenzoic Acids into their Benzylated Derivatives

The reaction of benzyl bromide with bis-(N- and C-ortho)-lithiated chloroanilides 4, 5, and 6 has been examined.It has been found that in the case where the lithiated compound was derived from meta-methoxyanilides, pre-addition of LiBr or TMEDA was required to achieve C-benzylation.These results were accounted for by the conversion of the usually formed dimer into a mixed dimer with the LiBr or TMEDA complex in which the C-lithium bond appears to be more accessible towards electrophiles.The practical synthesis of o-benzylchlorobenzoic acids 10, 11, and 12 was accomplished via ionic reductive cleavage (Et3SiH/TiCl4) of the corresponding phthalides 18, 19, and 20.The acids 10, 11b, and 11c afforded the corresponding anthrones, upon treatment with trifluoroacetic anhydride which were oxidized by chromium trioxide to the new chloroantraquinones 21, 22, and 23. - Keywords: Chlorophthalides; Reduction; Benzylation; Benzylbenzoic acids; Chloroantraquinones

Pyrrolo[3,4-d][2]benzazepinones

The present invention relates to compounds of the formula STR1 wherein R1 and R3 are selected from the group consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy or acyloxy and R2 and R4 are hydrogen or R

Pyrazolobenzazepines

There are presented compounds of the formulas STR1 wherein R1 is hydrogen or lower alkyl; R2 and R3 are selected from the group consisting of hydrogen, lower alkyl, C2 to C7 carboxylic acids, hydroxy

Pyrrolo[3,4-d][2]benzazepines

The present invention relates to compounds of the formula STR1 wherein R1 is selected from the group consisting of hydrogen, lower alkyl, C3 to C7 alkenyl or alkynyl, hydroxymethyl, the group STR2 wherein R11 is