856680-16-5

Upstream product

• 100-42-5 styrene 
• 90145-13-4 N'-<α-bromobenzylidene>-N-methylhydrazinium bromide 
• 13466-29-0 1-benzylidene-2-methylhydrazine 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 53657-63-9 1-methyl-5-phenyl-2-pyrazoline 
• 95684-22-3 (3R,5R)-1-Methyl-3,5-diphenyl-pyrazolidine 
• 94-41-7 benzalacetophenone 
• 60-34-4 methylhydrazine 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 

Downstream Products

• 19311-79-6 1-methyl-3,5-diphenyl-1H-pyrazole 

Relevant academic research and scientific papers

Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles

A series of 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles (3a-k and 4a-u) were designed, synthesized, and evaluated for their inhibitory efficacy towards the two hMAO isoforms. Most of the derivatives were found to be potent and selective hMAO-B inhibitors. In particular, derivative 3g showed greater hMAO-B affinity than selective inhibitor selegiline coupled with high selectivity index (SI = 145). The most selective hMAO-B inhibitor was the 3-methyl analogue 3f with an SI higher than 909.

A straightforward synthesis of pyrazolines and pyrazoles: Palladium-catalyzed carbonylative vinylation-cyclocondensation reactions of aryl halides

A novel consecutive one-pot synthesis of pyrazolines and pyrazoles starting from simple aryl halides, styrenes, carbon monoxide, and hydrazines has been established. Palladium-catalyzed carbonylative vinylation of aryl halides gave the corresponding chalcones, which are trapped in situ by addition of hydrazines.

Reactivity and Diastereoselectivity of Grignard Reagents towards the Hydrazone Functionality in Toluene Solvent

Grignard reagents, in toluene solvent, display a strongly increased reactivity toward the hydrazone functionality.With the chiral synthon 1, a highly diastereoselective addition occurs, through chelation control, whereas with pyrazolines 4 and 9 only the d,l diastereomer is formed, leading to a very short synthesis of 1,3-diphenyl-1,3-diaminopropane (11).

1,3-Dipolar Cycloadditions, 91. The Chemistry of N-Methyl-C-phenylnitrilimine

The treatment of N'--N-methylhydrazinium bromide, accessible by bromination of benzaldehyde-N-methylhydrazone, with triethylamine furnishes the title compound; this method is superior to the thermolysis and photolysis of 2-methyl-5-phe