9004-86-8Relevant articles and documents
Blossey et al.
, p. 5820 (1973)
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Windholz
, p. 2044 (1958)
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MICRO-ORGANIZATIONAL CONTROL OF PHOTOCHEMICAL OXIDATIONS: ROSE BENGAL AND DERIVATIVES (XV)
Neckers, D. C.,Paczkowski, Jerzy
, p. 4671 - 4684 (1986)
We define a microheterogeneous photo-oxidation to be a photosensitized oxidation reaction whose efficiency is enhanced beyond that of diffusion control by the covalent bonding of a sensitizer to a ligand.The ligand is responsible for enhancing the local concentration of a specific substrate susceptible to reaction with an excited state derived from the proximate sensitizer.We illustrate the principle with several applications in singlet oxygen processes.
Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds
Cheplakova, Anastasia M.,Solovieva, Anastasiya O.,Pozmogova, Tatiana N.,Vorotnikov, Yuri A.,Brylev, Konstantin A.,Vorotnikova, Natalya A.,Vorontsova, Elena V.,Mironov, Yuri V.,Poveshchenko, Alexander F.,Kovalenko, Konstantin A.,Shestopalov, Michael A.
, p. 100 - 107 (2017)
Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Matérial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.
Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases
Djapovic, Milica,Milivojevic, Dusan,Ilic-Tomic, Tatjana,Lje?evi?, Marija,Nikolaivits, Efstratios,Topakas, Evangelos,Maslak, Veselin,Nikodinovic-Runic, Jasmina
, (2021/03/01)
Polyethylene terephthalate (PET) is widely used material and as such became highly enriched in nature. It is generally considered inert and safe plastic, but due to the recent increased efforts to break-down PET using biotechnological approaches, we realized the scarcity of information about structural analysis of possible degradation products and their ecotoxicological assessment. Therefore, in this study, 11 compounds belonging to the group of PET precursors and possible degradation products have been comprehensively characterized. Seven of these compounds including 1-(2-hydroxyethyl)-4-methylterephthalate, ethylene glycol bis(methyl terephthalate), methyl bis(2-hydroxyethyl terephtahalate), 1,4-benzenedicarboxylic acid, 1,4-bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl] ester and methyl tris(2-hydroxyethyl terephthalate) corresponding to mono-, 1.5-, di-, 2,5- and trimer of PET were synthetized and structurally characterized for the first time. In-silico druglikeness and physico-chemical properties of these compounds were predicted using variety of platforms. No antimicrobial properties were detected even at 1000 μg/mL. Ecotoxicological impact of the compounds against marine bacteria Allivibrio fischeri proved that the 6 out of 11 tested PET-associated compounds may be classified as harmful to aquatic microorganisms, with PET trimer being one of the most toxic. In comparison, most of the compounds were not toxic on human lung fibroblasts (MRC-5) at 200 μg/mL with inhibiting concentration (IC50) values of 30 μg/mL and 50 μg/mL determined for PET dimer and trimer. Only three of these compounds including PET monomer were toxic to nematode Caenorhabditis elegans at high concentration of 500 μg/mL. In terms of the applicative potential, PET dimer can be used as suitable substrate for the screening, identification and characterization of novel PET-depolymerizing enzymes.
Solvent-free synthesis of symmetric methylene diestersviadirect reaction of aromatic carboxylates with 1,n-dihaloalkanes
Bai, Lin,Ding, Shenglong,Ma, Xiaofang
, p. 28711 - 28715 (2021/09/22)
An efficient methodology for the synthesis of symmetrical methylene diesters was developed through direct reaction of various aromatic carboxylates with 1,n-dihaloalkanes under solvent-free conditions. This strategy offers a high product yield, facile work-up and purification, and an environmentally friendly approach to obtain long-chain methylene carboxylate scaffolds with increased diversity.
