907997-19-7Relevant academic research and scientific papers
Synthesis of 3-phenyl-4-piperidones from acetophenone by shapiro and azamichael reactions and their further derivatization
Rosiak, Anna,Hoenke, Christoph,Christoffers, Jens
, p. 4376 - 4382 (2007)
The Shapiro reaction of acetophenone is the key in a convenient three-step access to a divinyl ketone which is further transformed by double aza-Michael reactions with primary amines into N-substituted 3-phenyl-4-piperidones. In the case of N-benzyl and N
Development of κ opioid receptor agonists by focusing on phenyl substituents of 4-dimethylamino-3-phenylpiperidine derivatives: Structure-activity relationship study of matrine type alkaloids
Teramoto, Hiroyoshi,Yamauchi, Takayasu,Sasaki, Shigeru,Higashiyama, Kimio
, p. 420 - 431 (2016/06/01)
A series of new κ opioid receptor (KOR) agonists were developed from the lead compound 4-dimethylamino-1-pentanoylpiperidine (3), a matrine-type alkaloid. Derivatives of 3 were synthesized with a variety of phenyl substituents and evaluated for their anti
Synthesis of tetrahydropyran-4-ones and thiopyran-4-ones from donor-substituted α-bromostyrene derivatives
Rosiak, Anna,Frey, Wolfgang,Christoffers, Jens
, p. 4044 - 4054 (2007/10/03)
Tetrahydropyran-4-one and tetrahydrothiopyran-4-one derivatives with a 3-aryl substituent were synthesized by double-conjugate addition of water or H2S to divinyl ketones. These starting materials were prepared in two steps by conversion of lit
Synthesis of 3-aryl-substituted tetrahydropyran-4-ones and tetrahydrothiopyran-4-ones
Rosiak, Anna,Christoffers, Jens
, p. 1434 - 1436 (2007/10/03)
A series of tetrahydropyran-4-one and tetrahydrothiopyran-4-one derivatives with 3-aryl or 3,6-diaryl substituents were prepared by double conjugate addition of water or H2S to divinyl ketones. These starting materials were accessed in two step
