90921-35-0

Basic information

• Product Name: Benzonitrile, 2-(1-Methylethoxy)-
• Synonyms: Benzonitrile, 2-(1-Methylethoxy)-;2-(1-methylethoxy)benzonitrile
• CAS NO: 90921-35-0
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• Mol File: 90921-35-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 271.1±13.0 °C(Predicted)
• Appearance: /
• Density: 1.03±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzonitrile, 2-(1-Methylethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-(1-Methylethoxy)-(90921-35-0)
• EPA Substance Registry System: Benzonitrile, 2-(1-Methylethoxy)-(90921-35-0)

Safety Data

• Hazardous Substances Data: 90921-35-0(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 2-(1-methylethoxy)-, also known as 2-(1-methylethoxy)benzonitrile, is a chemical compound with the molecular formula C10H11NO. It is a colorless liquid with a faint sweet odor and is insoluble in water. Benzonitrile, 2-(1-methylethoxy)- is commonly used as an industrial solvent and in the manufacturing of pharmaceuticals, dyes, and other organic compounds. It is also used as an intermediate in the synthesis of various chemicals and can be found in some consumer products. Benzoinitrile, 2-(1-methylethoxy)- is considered to be slightly toxic when ingested and may cause skin and eye irritation upon contact.

Upstream product

• 873-32-5 2-Chlorobenzonitrile 
• 67-63-0 isopropyl alcohol 
• 6609-54-7 2-cyanothioanisole 
• 100-39-0 benzyl bromide 
• 854696-81-4 2-propylsulfanylbenzonitrile 
• 394-47-8 2-fluorobenzonitrile 
• 218797-78-5 2-(tert-butoxy)benzonitrile 
• 6609-57-0 2-ethoxybenzonitrile 
• 6476-32-0 o-phenoxybenzonitrile 
• 6609-56-9 2-methoxy-benzonitrile 
• 403705-99-7 2-isopropoxybenzaldehyde O-methyloxime 
• 403705-98-6 2-ethoxybenzaldehyde O-methyloxime 
• 135-02-4 ortho-anisaldehyde 
• 22921-58-0 2-isopropoxybenzaldehyde 

Downstream Products

• 611-20-1 salicylonitrile 
• 6609-59-2 2-butoxybenzonitrile 
• 218797-78-5 2-(tert-butoxy)benzonitrile 
• 6609-56-9 2-methoxy-benzonitrile 
• 34825-99-5 2-(diphenylphosphanyl)benzonitrile 
• 74205-53-1 (2-Isopropoxy-phenyl)-acetonitrile 
• 540734-36-9 1-(chloromethyl)-2-(propan-2-yloxy)benzene 
• 82657-68-9 [2-(propan-2-yloxy)phenyl]methanol 
• 63635-26-7 2-isopropoxybenzoic acid 
• 227199-51-1 (2-(isopropyloxy)phenyl)methanamine 
• 52561-91-8 2-(5-phenyl-[1,2,4]oxadiazol-3-yl)phenol 
• 876162-20-8 4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester 
• 876162-18-4 4-[2-(5-cyclohexyl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester 
• 876162-16-2 4-[2-(5-cyclopentyl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester 

Relevant articles and documents

Nucleophilic Amination and Etherification of Aryl Alkyl Thioethers

A transition-metal-free protocol capable of synthesizing diarylated aniline derivatives is reported. This method could be further employed to prepare aryl alkyl ethers. A wide range of thioethers, anilines, as well as alcohols were tolerated thanks to the mild reaction conditions. The strength of our method was demonstrated by performing a gram-scale reaction (20 mmol) followed by conversion of the nitrile group into synthetically useful aldehyde, ketone, and carboxylic acid.

Exploiting ancillary ligation to enable nickel-catalyzed c-o cross-couplings of aryl electrophiles with aliphatic alcohols

The use of (L)Ni(o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos) enables the C(sp2)-O cross-coupling of primary, secondary, or tertiary aliphatic alcohols with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C(sp2)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods.

Dynamic kinetic asymmetric synthesis of substituted pyrrolidines from racemic cyclopropanes and aldimines: Reaction development and mechanistic insights

An enantioselective preparation of 2,5-cis-disubstituted pyrrolidines has been achieved via a dynamic kinetic asymmetric transformation (DyKAT) of racemic donor-acceptor cyclopropanes and (E)-aldimines. Mechanistic studies suggest that isomerization of the aldimine or resultant iminium to the Z geometry is not a pathway that furnishes the observed 2,5-cis-disubstituted products.