91851-17-1

Basic information

• Product Name: 2-(4-Bromoanilino)-1-phenyl-1-ethanol
• Synonyms: 2-(4-Bromoanilino)-1-phenyl-1-ethanol;2-(4-bromoanilino)-1-phenylethanol
• CAS NO: 91851-17-1
• Molecular Formula: C₁₄H₁₄BrNO
• Molecular Weight: 292.17106
• Mol File: 91851-17-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Bromoanilino)-1-phenyl-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Bromoanilino)-1-phenyl-1-ethanol(91851-17-1)
• EPA Substance Registry System: 2-(4-Bromoanilino)-1-phenyl-1-ethanol(91851-17-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 91851-17-1(Hazardous Substances Data)

Usage

Physical state

White to off-white solid

Pharmaceutical use

Building block for the synthesis of various compounds

Medical use

Mucolytic drug for treating respiratory disorders such as chronic bronchitis and chronic obstructive pulmonary disease

Mechanism of action

Thins and loosens mucus in the airways, making it easier to cough up

Potential properties

Antitumor and cytotoxic effects

Versatility

Versatile compound with various pharmaceutical applications

Upstream product

• 98-86-2 acetophenone 
• 28193-69-3 N-(4-bromophenyl)-2-oxo-2-phenylacetamide 
• 13370-62-2 N‐(4-bromophenyl)glycine 
• 100-52-7 benzaldehyde 
• 96-09-3 styrene oxide 
• 586-78-7 para-nitrophenyl bromide 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 536-74-3 phenylacetylene 
• 1333483-14-9 N-methyll-N-(phenylethylnyl)methanesulfonamide 
• 4831-21-4 2-((4-bromophenyl)amino)-1-phenylethan-1-one 
• 106-40-1 4-bromo-aniline 
• 91851-01-3 2-(4-Bromo-phenylamino)-2-hydroxy-1-phenyl-ethanone 
• 79866-42-5 p-bromo-N-(α-methoxyphenacyl)aniline 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 

Relevant articles and documents

Synthesis, characterization and catalytic application of Bi2S3 microspheres for Suzuki-Miyaura cross-coupling reaction and chemoselective ring opening of epoxides

Bismuth sulfide (Bi2S3) prepared using L-cysteine, which served as both the sulfur source and the directing molecule for the formation of Bi2S3 as heterogeneous catalyst through solvothermal method. The prepared catalyst was examined by various techniques such as XRD, BET, FE-SEM, TEM, and TGA analysis. The results and analysis revealed that bismuth microspheres have better catalytic behavior for the preparation of biphenyl in water as a greenest solvent and for the ring opening of epoxides by nucleophiles including amines, alcohol, and thiol compared to pure Bi(NO3)3. 3H2O under solvent-free condition. Moreover, the novel catalyst could be recovered and reusedat least four times without loss of its catalytic activity.

Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds: Via visible-light photocatalyst in water

A general and efficient visible-light photoredox-catalysed decarboxylative radical coupling reaction of N-aryl amino acids with aldehydes or ketones for the synthesis of various 1,2-amino alcohols by using water as the solvent at room temperature is described. This protocol is characterised by broad substrate scopes, mild reaction conditions and amenability to gram-scale synthesis, which opens up a simple, mild but effective method to produce 1,2-amino alcohols from readily available starting materials.

Synthesis of β-amino alcohols using the tandem reduction and ring-opening reaction of nitroarenes and epoxides

A high yield one-pot synthesis of β-amino alcohols from nitroarenes and 1,2-epoxides was developed, which utilizes inexpensive iron dust as a reducing agent and NH4Cl as the only additive in a 50% (v/v) ethanol solution. This new efficient synthetic approach tolerates a wide range of functionalities. The mild reaction conditions (e.g., 60?°C), together with the use of low cost and readily available starting materials, make this synthetic approach an attractive alternative to the current synthesis of β-amino alcohols.