92935-45-0

Upstream product

• 5445-17-0 Methyl 2-bromopropionate 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 3209-33-4 trans-3-methyloxirane-2-carbaldehyde 
• 4324-37-2 2-methoxypropionic acid 
• 3043-33-2 2-methyl-2,3-pentadiene 
• 470-23-5 D-fructose 
• 9004-34-6 cellulose 
• 2280-44-6 D-Glucose 
• 27871-49-4 (S)-Methyl lactate 
• 547-64-8 methyl lactate 
• 20047-41-0 (2R)-methyl 2-bromopropionate 
• 74-88-4 methyl iodide 
• 79-33-4 L-Lactic acid 

Downstream Products

• 887029-63-2 (2R)-2-methoxypropanehydrazide 
• 130192-75-5 (3R,4S,5S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-3,5-dimethyl-dihydro-furan-2-one 
• 130050-89-4 Methyl (2S,3S,4S)-3-hydroxy-2-methyl-2-methoxy-4-<(1,1-dimethylethyldiphenylsilyl)oxy>pentanoate 
• 130050-90-7 (2R,3S,4S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methoxy-2-methyl-pentanoic acid methyl ester 
• 97562-15-7 methyl 4-O-benzyl-5-deoxy-2-C-methyl-2-O-methyl-L-xylonate 
• 97562-15-7 methyl 4-O-benzyl-5-deoxy-2-C-methyl-2-O-methyl-4-L-ribonate 
• 97562-15-7 methyl 4-O-benzyl-5-deoxy-2-C-methyl-2-O-methyl-4-L-lyxonate 
• 97562-15-7 methyl 4-O-benzyl-5-deoxy-2-C-methyl-2-O-methyl-L-arabinoate 
• 97562-15-7 (S)-4-Benzyloxy-3-hydroxy-2-methoxy-2-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii

The outer surfaces of mycobacteria, including the organism that causes tuberculosis, are decorated with an array of immunomodulatory glycans. Among these are lipooligosaccharides (LOSs), a class of molecules for which the function remains poorly understoo

(Meth) acrylic acid ester, a hydroxy compound, (meth) acrylic ester production and (by machine translation)

(Meth) acrylic acid ester and a manufacturing method thereof [to] excellent hydrophilicity. [Solution] for example, compound (5 - 1) is represented by the new of a methacrylic ester. (5 - 1) (4 - 1) Is a novel compound can be produced by reacting methacrylic acid chloride derivatives of cyclopentanol. [Drawing] no (by machine translation)

PRODUCTION OF ALKYL ESTERS OF ACRYLIC ACID

A process for producing a mixture including acrylic acid or derivatives thereof, the process including the step of contacting a mixture of lactic acid or derivatives thereof and a solvent over a dehydration catalyst to produce the mixture including alkyl esters of acrylic acid, wherein the density of the solvent ranges from about 10 to about 500 kg/m3 under operating conditions.

Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water

Biologically relevant hydrophilic molecules rarely interact with hydrophobic compounds and surfaces in water owing to effective hydration. Nevertheless, herein we report that the hydrophobic cavity of a polyaromatic capsule, formed through coordination-driven self-assembly, can encapsulate hydrophilic oligo(lactic acid)s in water with relatively high binding constants (up to Ka=3×105 m?1). X-ray crystallographic and ITC analyses revealed that the unusual host–guest behavior is caused by enthalpic stabilization through multiple CH–π and hydrogen-bonding interactions. The polyaromatic cavity stabilizes hydrolyzable cyclic di(lactic acid) and captures tetra(lactic acid) preferentially from a mixture of oligo(lactic acid)s even in water.

Selective Hydrodeoxygenation of Alkyl Lactates to Alkyl Propionates with Fe-based Bimetallic Supported Catalysts

Hydrodeoxygenation (HDO) of methyl lactate (ML) to methyl propionate (MP) was performed with various base-metal supported catalysts. A high yield of 77 % MP was obtained with bimetallic Fe–Ni/ZrO2 in methanol at 220 °C and 50 bar H2. A synergistic effect of Ni increased the yield of MP significantly when using Fe–Ni/ZrO2 instead of Fe/ZrO2 alone. Moreover, the ZrO2 support contributed to improve the yield as a phase transition of ZrO2 from tetragonal to monoclinic occurred after metal doping giving rise to fine dispersion of the Fe and Ni on the ZrO2, resulting in a higher catalytic activity of the material. Interestingly, it was observed that Fe–Ni/ZrO2 also effectively catalyzed methanol reforming to produce H2 in situ, followed by HDO of ML, yielding 60 % MP at 220 °C with 50 bar N2 instead of H2. Fe–Ni/ZrO2 also catalyzed HDO of other short-chain alkyl lactates to the corresponding alkyl propionates in high yields around 70 %. No loss of activity of Fe–Ni/ZrO2 occurred in five consecutive reaction runs demonstrating the high durability of the catalyst system.

Catalytic Gas-Phase Production of Lactide from Renewable Alkyl Lactates

A new route to lactide, which is a key building block of the bioplastic polylactic acid, is proposed involving a continuous catalytic gas-phase transesterification of renewable alkyl lactates in a scalable fixed-bed setup. Supported TiO2/SiO2 catalysts are highly selective to lactide, with only minimal lactide racemization. The solvent-free process allows for easy product separation and recycling of unconverted alkyl lactates and recyclable lactyl intermediates. The catalytic activity of TiO2/SiO2 catalysts was strongly correlated to their optical properties by DR UV/Vis spectroscopy. Catalysts with high band-gap energy of the supported TiO2 phase, indicative of a high surface spreading of isolated Ti centers, show the highest turnover frequency per Ti site.

ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS

The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.

METHODS OF TREATING PULMONARY DISEASES AND DISORDERS

The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.

Direct conversion of cellulose to high-yield methyl lactate over Ga-doped Zn/H-nanozeolite Y catalysts in supercritical methanol

For realizing sustainable bio-based refineries, it is crucial to obtain high yields of value-added chemicals via the direct conversion of cellulose and lignocellulosic biomass. Although the conversion of cellulose using homogeneous catalysts has been demonstrated to be quite successful, low cellulose conversion and poor product selectivity have been observed using heterogeneous catalysts. In this study, for the first time, the efficient conversion of cellulose to lactic acid derivatives, which can be used as a green solvent and a potential precursor for fine chemicals and biodegradable polymers, over a Ga-doped Zn/H-nanozeolite Y (Ga-doped Zn/HNZY) catalyst is described. Under optimized conditions at 280°C in supercritical methanol, methyl lactate (ML) and methyl 2-methoxypropionate (MMP) are obtained in yields of 57.8% and 12.8%, respectively, from cellulose; these values are greater than those reported in previous studies conducted using heterogeneous catalysts. Using oakwood, ML and MMP are obtained in yields of 12.3% and 18.6%, respectively. A large external surface area of the HNZY support and the synergistic effect of Ga doping on ZnO enhance Lewis acid sites with the simultaneous decrease of the Br?nsted acid sites. This unique catalyst (Ga-doped Zn/HNZY) is beneficial for controlling the consecutive reaction pathways of the decomposition of cellulose to glucose, retro-aldol condensation to trioses, and intramolecular Cannizzaro reaction to ML.

Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents

The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds such as ibuprofen. With chiral lactic acid-based iodine(III) reagents product selectivities of up to 73 % ee have been achieved.