93876-30-3

Upstream product

• 532-32-1 sodium benzoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 583-04-0 vinyl benzoate 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 611-73-4 Benzoylformic acid 
• 108-88-3 toluene 
• 65-85-0 benzoic acid 
• 94-36-0 dibenzoyl peroxide 

Relevant academic research and scientific papers

One-pot synthesis of α-acyloxycarbonyl compounds via oxidative decarboxylation coupling reaction of α-oxo carboxylic acids with carbonyl compounds

With tetrabutylammonium iodide (TBAI) as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant, a simple metal-free protocol has been developed for the synthesis of α-acyloxycarbonyl compounds from carbonyl compounds and α-oxo carboxylic acids via decarboxylative coupling reaction. The target products could be obtained in moderate to high yields.

Preparation method of alpha-acyloxy ketone compound

The invention discloses a preparation method of an alpha-acyloxy ketone compound, which comprises the following steps of adding a 1, 3-dicarbonyl compound, carboxylate and a catalyst alkyl halide into an organic solvent, and stirring and reacting for 0.5-1 hour at the temperature of 20-30 DEG C to obtain a reaction product, namely a mixture, performing purification treatment on the mixture to obtain alpha-acyloxy ketone, wherein the molar ratio of the 1, 3-dicarbonyl compound to the carboxylate to the alkyl halide is 1: 1: 1. According to the method, carboxylate with low cost is selected as an acyloxylation reagent, reaction conditions are mild and green, a 1, 3-dicarbonyl compound is taken as a raw material, and a novel method for efficiently, simply and conveniently constructing a C-O bond is successfully realized through activation of a carbonyl alpha-position C-H bond and subsequent cascade reaction, so that a series of alpha-acyloxyketone compounds are obtained.

Unified and Benign Synthesis of Spirooxindoles via Bifunctional and Recyclable Iodide-Salt-Catalyzed Oxidative Coupling in Water

Herein we develop a novel micellar catalytic system based on amphiphilic bifunctional iodide salts for oxidative intramolecular α-oxygenation and α-amination of carbonyl substrates in water, thus enabling a unified and benign synthesis of various 2-oxindo

Electrochemically Induced Intermolecular Cross-Dehydrogenative C-O Coupling of β-Diketones and β-Ketoesters with Carboxylic Acids

The electrochemically induced cross-dehydrogenative C-O coupling of β-diketones and β-ketoesters (C-H reagents) with carboxylic acids (O-H reagents) was developed. An important feature of this reaction lies in the selective formation of intermolecular C-O

Bu4NI-Catalyzed α-Oxyacylation of Carbonyl Compounds with Toluene Derivatives

A TBAI (tetrabutylammonium iodide)-catalyzed direct α-oxyacylation of carbonyl compounds from readily available toluene derivatives has been developed. The distinguished features of this metal-free protocol include the employment of simple starting material, a wide carbonyl compound scope, and mild reaction conditions.

Relay Rh(II)/Pd(0) dual catalysis: Selective construction of cyclic all-quaternary carbon centers

A novel relay Rh(II)/Pd(0) dual catalysis strategy that promotes the divergent reaction of α-diazo-carbonyl compounds with allylic carboxylates for the selective construction of cyclic all-quaternary carbon centers has been developed. This binary catalyst

TBAI-catalyzed oxidative coupling of β-ketoesters with carboxylic acid: Synthesis of α-carboxylic-β-ketoesters

TBAI-catalyzed oxidative coupling of β-ketoesters with carboxylic acid using TBHP as oxidant has been established. This transformation provides a facile and direct strategy for the synthesis of α-carboxylic-β- ketoesters. ARKAT-USA, Inc.