94-46-2Relevant articles and documents
LiHMDS: Facile, highly efficient and metal-free transesterification under solvent-free condition
Gore, Kiran R.,Mittapelli, Lavanya L.
, (2020/10/27)
Transesterification is one of the important organic reactions employed in numerous industrial as well as laboratory applications for the synthesis of various esters. Herein, we report a rapid, highly efficient, and transition metal-free transesterification reaction in the presence of LiHMDS under solvent-free conditions. The transesterification reaction was carried out with three different benzoate esters and a wide range of primary and secondary alcohols (from C3-C18) in good to excellent yields (45 examples). By considering the commercial role of esters, this method will be promising for the facile synthesis of esters in industry-relevant applications.
Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates
Ye, Yang,Ma, Guobin,Yao, Ken,Gong, Hegui
supporting information, p. 1625 - 1628 (2021/01/18)
Herein we describe a general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions. The reduction method is suitable for an array of structural motifs derived from tertiary alcohols that bear diverse functional groups, including the synthesis of a key intermediate en route to estrone.
Method for reductive hydrogenation of tertiary alkyl alcohol
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Paragraph 0033-0045, (2020/07/15)
The invention discloses a method for reductive hydrogenation of tertiary alkyl alcohol. The method comprises the following steps: using oxalic ester prepared from tertiary alkyl alcohol in advance asa raw material, reacting at 40-60 DEG C for 8-12 hours under the actions of a nickel source, a ligand, a hydrogen donor, a reducing agent, an additive and a solvent to obtain a product of reductive hydrogenation of tertiary alkyl alcohol. Tertiary alkyl oxalate prepared from tertiary alkyl alcohol is used as a reaction precursor, zinc powder/magnesium chloride is used as a medium for catalytic reduction of non-activated tertiary alkyl oxalate, nickel promotes breakage of C-O bonds of oxalate, and diphenyl silane is used as a hydrogen donor for preparation of a reduction product. According to the method, the adopted catalyst metal is cheap, the raw materials are simple and easy to obtain, the reaction is mild and one-step, the steps are simple, the operation is safe, the yield is high, andthe cost is low.