946129-85-7

Basic information

• Product Name: 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide
• Synonyms: 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide
• CAS NO: 946129-85-7
• Molecular Weight: 512.518
• Mol File: 946129-85-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide(946129-85-7)
• EPA Substance Registry System: 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide(946129-85-7)

Safety Data

• Hazardous Substances Data: 946129-85-7(Hazardous Substances Data)

Upstream product

• 946126-93-8 C₂₃H₁₈FN₃O₇S 
• 74-89-5 methylamine 
• 946130-13-8 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 946125-65-1 1-(bromomethyl)-2-fluoro-3- nitrobenzene 
• 53553-14-3 2-chloro-3-nitrobenzoic acid methyl ester 
• 946126-94-9 2-fluoro-3-nitrobenzoic acid methyl ester 
• 946126-95-0 (2-fluoro-3-nitrophenyl)methanol 
• 946126-97-2 2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran 
• 3970-40-9 2-chloro-3-nitrotoluene 
• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 946130-07-0 2-(2-fluoro-3-nitrobenzyl)-3-oxo-butyric acid ethyl ester 
• 946126-42-7 4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 

Relevant articles and documents

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY

The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from -N= etc., Y3 and Y4 are selected from -CH= etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.