95119-41-8

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 645-49-8 cis-stilben 
• 64200-25-5 ethyl ester of 2β,3β-diphenylcyclopropane-1α-carboxylic acid 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 82665-91-6 α,α-diiodoethylacetate 
• 588-59-0 stilbene 

Downstream Products

• 3471-08-7 cis-2,3-diphenylcyclopropanecarboxylic acid 
• 7381-90-0 cis, trans-1-hydroxymethyl-2,3-diphenylcyclopropane 
• 52456-99-2 trans-2,3-diphenylcyclopropane-1-carbaldehyde 
• 3471-08-7 (2SR,3SR)-2,3-diphenylcyclopropanecarboxylic acid 
• 10539-10-3 trans-1,2,3-triphenylcyclopropane 
• 57772-73-3 ethyl 2-benzyl-3-phenylpropionate 
• 72277-18-0 ethyl 3,4-diphenylbutanoate 
• 95940-80-0 (+/-)-2r,3t-diphenyl-cyclopropane-carboxylic acid-⁽¹⁾-(2-diethylamino-ethyl ester); hydrochloride 
• 105311-12-4 (+/-)-2r.3t-diphenyl-cyclopropane-carbanilide-⁽¹⁾ 
• 20431-65-6 ethyl N-nitroso-N-((E)-2,3-diphenylcyclopropyl)carbamate 
• 20431-64-5 ethyl N-((E)-2,3-diphenylcyclopropyl)carbamate 
• 19817-60-8 1-Methoxy-trans-2,3-diphenyl-cyclopropan 
• 3780-00-5 1-(3-phenyl-1,2-propadienyl)benzene 
• 71569-49-8 2r,3c-diphenyl-cyclopropane-carboxylic acid-(1ξ)-amide 

Relevant academic research and scientific papers

Synthesis Method of Cyclopropane or Cyclopentene Derivatives via Fe-catalyzed Cationic Radical Cycloaddition Reaction

In this disclosure Fe (III) complex is used as an electron oxidizing agent to oxidize an electron - rich alkene compound to form a radical cation intermediate, and then a cyclopropane compound or 3 5-membered ring compound is synthesized by inducing a cycloaddition reaction with the diazo compound.

Cycloaddition Reactions of Alkene Radical Cations using Iron(III)-Phenanthroline Complex

Single electron oxidation of electron-rich alkenes using the iron(III)-phenanthroline complex produced electrophilic alkene radical cations, which promoted efficient radical cation [2+1] cycloaddition reactions with diazo compounds. Subsequent chain propagation afforded tri- and tetra-substituted cyclopropanes. This methodology was also expanded to [3+2] cycloaddition reactions with vinyl diazoesters, validating this sustainable, first-row transition metal iron system for the single electron redox reactions. (Figure presented.).

Cyclopropane-alkene metathesis by gold(i)-catalyzed decarbenation of persistent cyclopropanes

A gold(i)-catalyzed cyclopropane-alkene metathesis has been demonstrated with two new families of cyclopropane derivatives of naphthalene and phenanthrene (benzo-fused norcaradienes). In this process, metal carbene units are transferred from a persistent

Rhodium Porphyrin Catalyzed Regioselective Transfer Hydrogenolysis of C-C σ-Bonds in Cyclopropanes with iPrOH

A new rhodium porphyrin catalyzed regioselective transfer hydrogenolysis of both activated and unactivated cyclopropanes employing iPrOH as the hydrogen source was discovered. The reaction mechanism for the C-C σ-bond activation of cyclopropanes was identified through an initial radical substitution with rhodium(II) metalloporphyrin radical to give a rhodium porphyrin alkyl, followed by hydrogenolysis with iPrOH to give the corresponding acyclic alkanes and regenerate rhodium(II) metalloporphyrin radical.

A transition-metal-free & diazo-free styrene cyclopropanation

An operationally simple and broadly applicable novel cyclopropanation of styrenes using gem-diiodomethyl carbonyl reagents has been developed. Visible-light triggered the photoinduced generation of iodomethyl carbonyl radicals, able to cyclopropanate a wide array of styrenes with excellent chemoselectivity and functional group tolerance. To highlight the utility of our photocyclopropanation, we demonstrated the late-stage functionalization of biomolecule derivatives.

Radical Cation Cyclopropanations via Chromium Photooxidative Catalysis

The chromium photocatalyzed cyclopropanation of diazo reagents with electron-rich alkenes is described. The transformation occurs under mild conditions and features specific distinctions from traditional diazo-based cyclopropanations (e.g., avoiding β-hydride elimination, chemoselectivity considerations, etc.). The reaction appears to work most effectively using chromium catalysis, and a number of decorated cyclopropanes can be accessed in generally good yields.

Spin-selective generation of triplet nitrenes: Olefin aziridination through visible-light photosensitization of azidoformates

Azidoformates are interesting potential nitrene precursors, but their direct photochemical activation can result in competitive formation of aziridination and allylic amination products. Herein, we show that visible-light-activated transition-metal comple

Wittig reagents as metallocarbene precursors: In situ generated monocarbonyl iodonium ylides

A proof of concept study was undertaken to determine the suitability of monocarbonyl iodonium ylides (MCIYs) as metallocarbene precursors. Exposing Wittig reagents to iodosylbenzene results in a pseudo-Wittig reaction that generates MCIYs in situ. These ylides are intercepted by transition-metal catalysts to generate metallocarbenes, which then undergo either dimerization or cyclopropanation reactions with a variety of alkenes. Additionally, the reaction between diazoester-derived metallocarbenes and Wittig reagents afforded cross-coupling products, illustrating a new type of olefination reaction for phosphonium ylides. Monocarbonyl iodonium ylides (MCIYs) represent a possible alternative to the use diazoketones and -esters as metallocarbene precursors. Upon treatment with iodosylbenzene, a Wittig reagent will undergo ylide transfer to generate a MCIY in situ. In the presence of transition-metal catalysts, MCIYs serve as precursors to metallocarbenes, which undergo dimerization or cyclopropanation of alkenes. tfacac = trifluoroacetylacetonate. Copyright

The influence of chiral auxiliaries is enhanced within zeolites

Zeolites significantly enhance the influence of chiral auxiliaries during photochemical reactions. The generality of this phenomenon has been tested with three independent examples. Chiral auxiliaries that lead to 1:1 mixtures of diastereomers in solution

Acyl guanidine sodium/proton exchange inhibitors and method

Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure STR1 wherein n is 1 to 5; X is N or C--R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R1, R2, R3 and R4 are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.