Bioorganic and Medicinal Chemistry p. 2129 - 2132 (1997)
Update date:2022-08-28
Topics:
Micheli, Fabrizio
Cugola, Alfredo
Donati, Daniele
Missio, Andrea
Pecunioso, Angelo
Reggiani, Angelo
Tarzia, Giorgio
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo.
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