98-47-5Relevant articles and documents
Effect of solvent on the kinetics of arylsulfonylation of N-alkylated anilines in a water-propan-2-ol system
Kustova,Sterlikova
, p. 973 - 975 (2006)
The effect of the composition of a water-propan-2-ol solvent on the kinetics of arylsulfonylation of N-ethyl-, N-isopropyl-, and N-butylanilines with 3-nitrobenzenesulfonyl chloride at 298 K was studied. The reaction rate constant increases monotonically with an increase in the water fraction in the solvent from 5 to 30 wt.%. The apparent activation parameters of the reaction of N-butylaniline with 3-nitrobenzenesulfonyl chloride were calculated. No considerable changes in the activation parameters of the reaction were observed on going from pure propan-2-ol to a 10% aqueous solution, which indicates that the mechanism remains unchanged upon solvent change. Propan-2-ol with a water content of 5-30 wt.% can be used in the synthesis of arylsulfonylation products of the amines under study in 98-99% yield.
Stilbene type compound as well as synthesis method and application thereof
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Paragraph 0008; 0037; 0048; 0059, (2021/07/01)
The invention discloses a stilbene type compound as well as a synthesis method and application thereof, wherein the synthesis method comprises the steps: taking an intermediate 2 and an intermediate 4 as initiators, sequentially carrying out Wittig reaction, reduction reaction, amino protection reaction, condensation reaction, deprotection reaction and amidation reaction, and then refining to obtain the stilbene type compound. The synthesis process is high in controllability, used reagents are low in price, and the method is simple and easy to industrialize. The stilbene type compound can be used as a medicine for resisting tumors and viruses and treating fungal infection and cardiovascular and cerebrovascular diseases.
Reactivity of 2-Sulfobenzoic Acid Imide and Benzenesulfonamide in Arenesulfonylation
Kustova,Agafonov,Kruglyakova,Kochetova
, p. 792 - 795 (2019/08/02)
Experimental study of the kinetics of the reactions of 2-sulfobenzoic acid imide (saccharin) and benzenesulfonamide with 3-nitrobenzenesulfonyl chloride in a 1,4-dioxane-water mixture (80:20 by weight) in the temperature range 298–318 K has shown that both compounds are low reactive (k298 = 1.66 × 10?4 and 3.37 × 10?3 L mol?1 s?1, respectively). The activation barriers to these reactions exceed 50 kJ/mol. Aqueous dioxane can be recommended as a solvent for the preparation of N-(benzenesulfonyl)-3-nitrobenzenesulfonamide in up to 87% yield.
Regioselective Sulfonation of Aromatic Compounds over 1,3-Disulfonic Acid Imidazolium Chloride under Aqueous Media
Moosavi-Zare, Ahmad Reza,Zolfigol, Mohammad Ali,Noroozizadeh, Ehsan
, p. 1682 - 1684 (2016/07/06)
1,3-Disulfonic acid imidazolium chloride ([Dsim]Cl), as a Bronsted acidic ionic liquid, is introduced for the sulfonation of aromatic compounds by in situ generation of sulfuric acid at 50 °C under mild conditions and in aqueous medium.
