98139-95-8

Upstream product

• 67-66-3 chloroform 
• 930-66-5 1-chlorocyclohexene 
• 7726-95-6 bromine 
• 108-94-1 cyclohexanone 

Downstream Products

• 930-66-5 1-chlorocyclohexene 
• 55949-57-0 2-chloro-1,3-cyclohexadiene 
• 108-90-7 chlorobenzene 
• 71-43-2 benzene 
• 87-82-1 hexabromobenzene 
• 224316-65-8 (E)-3-(2-{(E)-2-[(1R,2S,5R)-5-Methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-vinyl}-cyclohex-1-enyl)-acrylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 131496-57-6 1,2-bis[(E)-2-trimethylsilylethenyl]cyclohexene 
• 114493-71-9 1,2-diiodocyclohex-1-ene 
• 30984-03-3 cis-2,3-Diphenyl-2,3,5,6,7,8-hexahydro-naphthalin 
• 30984-01-1 1,2-(E,E)-distyrylcyclohexene 
• 20696-89-3 cyclohexene-d₂^1,2 
• 49676-92-8 1,2-dibromocyclohex-1-ene 

Relevant academic research and scientific papers

AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF

Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin compound of the present invention is a novel ALK5 inhibitor and is for use in treating and/or preventing various ALK5-mediated diseases.

FATTY ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREFOR

The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.

Auto-tandem catalysis: Synthesis of acridines by Pd-catalyzed C=C bond formation and C(sp2)-N cross-coupling

A facile palladium-catalyzed synthesis of acridines has been realized by consecutive C=C double bond formation and C-N cross-coupling. A variety of functionalized acridines can be accessed from easily available o-dihalobenzenes and N-tosylhydrazones in a single operation. This one-pot protocol has a wide scope with respect to both coupling partners, and provides an efficient route to functionalized acridine derivatives, which are generally difficult to synthesize by previously known methods.

The twofold Heck reaction on 1,2-dihalocycloalkenes and subsequent 6π-electrocyclization of the resulting (E,Z,E)-1,3,5-hexatrienes: A new formal {2+2+2}-assembly of six-membered rings

1,6-Disubstituted (E,Z,E)-1,3,5-hexatrienes (4 and 5) were prepared by vicinal twofold Heck coupling reactions from 1,2-dibromocyclopentene (1), 1,2-dibromocyclohexene (2), 1,2-diiodocyclopentene (8), 1,2-diiodocyclohexene (9), 1-bromo-2-trifluoromethanes