Representative 11b-HSD1 inhibitors

January 08, 2024

• Title:       

  Representative 11b-HSD1 inhibitors

• Image Source:

  Pyrrolidine-pyrazole ureas as potent and selective inhibitors  of 11b-hydroxysteroid-dehydrogenase type 1

• FigureMark:

  Figure 2

• Associated context:

  In the last decade, several classes of 11b-HSD1 inhibitors have  been identified by the pharmaceutical industry and academic  groups.⁸ These included sulfonamides such as BVT.2733 or PF-915275,^9,10 triazoles such as the Merck compound 544,¹¹ and  thiazolones such as Amgen compound AMG221 (Fig. 2).¹²