Structure and Binding Affinities of Chk1 Inhibitors

August 13, 2024

• Title:       

  Structure and Binding Affinities of Chk1 Inhibitors 

• Image Source:

  Structure-based design of novel Chk1 inhibitors Insights into hydrogen bonding and protein-ligand affinity

• Mark:

  Table 1

• Associated context:

  Compound 1 (Table 1) was identified as an inhibitor of human Chk1 during a medium throughput screen of a commercial library of compounds provided by Chemical  Diversity (ChemDiv).44 In that screen, compound 1  inhibited Chk1 with an IC50 of 15.4 µM. It was further shown that compound 1 inhibits Chk1 in an ATP-  competitive manner by standard kinetic methods, with a Ki of 7.2 µM.